1-(1-溴-1-苯基甲基)环丙基溴 | 41893-70-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(1-溴-1-苯基甲基)环丙基溴
• 英文名称: 1-(1-bromo-1-phenylmethyl)cyclopropyl bromide
• 英文别名: α-(1-Bromcyclopropyl)-benzylbromid；Benzene, [bromo(1-bromocyclopropyl)methyl]-；[bromo-(1-bromocyclopropyl)methyl]benzene
• CAS: 41893-70-3
• 化学式: C₁₀H₁₀Br₂
• 分子量: 289.997
• InChiKey: FDCTZCKLFAUCBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-(1-溴-1-苯基甲基)环丙基溴 在 氢氧化钾 、 silica gel 作用下， 生成 (1-bromo-1-phenylmethylene)cyclopropane
  参考文献：
  名称：

  Derocque,J.-L. et al., Justus Liebigs Annalen der Chemie, 1973, p. 419 - 431

  摘要：

  DOI：
• 作为产物：
  描述：

  环亚丙基甲基苯 在 溴 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 以61%的产率得到1-(1-溴-1-苯基甲基)环丙基溴
  参考文献：
  名称：

  Thermolysis of 1-(1-Aryl-1-bromomethyl)cyclopropyl Bromides:  A Reinvestigation

  摘要：

  Two compounds, the (Z)- and (E)-isomers of 2,4-dibromo-1-p-tolyl-1-butene 2a and 3a, respectively, were isolated in 65% total yield when 1-(1-bromo-1-p-tolylmethyl)cyclopropyl bromide (1a) was heated at 150 degreesC for 1 h. 1,1-Dibromo-2-p-tolylcyclobutane (4a), previously reported to be the only product in this reaction, was not detected. The phenyl analogue of la reacted similarly and gave the (Z)- and (E)-isomers of 2,4-dibromo-1-phenyl-1-butene 2b and 3b, respectively, in 60% yield. A rationale for the reaction is presented.

  DOI：

  10.1021/jo034431m

文献信息

• Derocque,J.-L. et al., Justus Liebigs Annalen der Chemie, 1973, p. 419 - 431
  作者：Derocque,J.-L. et al.

  DOI：——

  日期：——
• Thermolysis of 1-(1-Aryl-1-bromomethyl)cyclopropyl Bromides:  A Reinvestigation
  作者：Tore Nordvik、Udo H. Brinker

  DOI：10.1021/jo034431m

  日期：2003.9.1

  Two compounds, the (Z)- and (E)-isomers of 2,4-dibromo-1-p-tolyl-1-butene 2a and 3a, respectively, were isolated in 65% total yield when 1-(1-bromo-1-p-tolylmethyl)cyclopropyl bromide (1a) was heated at 150 degreesC for 1 h. 1,1-Dibromo-2-p-tolylcyclobutane (4a), previously reported to be the only product in this reaction, was not detected. The phenyl analogue of la reacted similarly and gave the (Z)- and (E)-isomers of 2,4-dibromo-1-phenyl-1-butene 2b and 3b, respectively, in 60% yield. A rationale for the reaction is presented.