1-(1-苯基丙-2-烯基)哌啶 | 120446-69-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-(1-苯基丙-2-烯基)哌啶
• 英文名称: 1-(1-phenyl-2-propenyl)piperidine
• 英文别名: Piperidine, 1-(1-phenyl-2-propenyl)-；1-(1-phenylprop-2-enyl)piperidine
• CAS: 120446-69-7
• 化学式: C₁₄H₁₉N
• 分子量: 201.312
• InChiKey: LEWMUNHKWOGMOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-苯基丙-2-烯-1-醇 在 bis(1,5-cyclooctadiene)diiridium(I) dichloride 吡啶 、 (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 生成 1-(1-苯基丙-2-烯基)哌啶
  参考文献：
  名称：

  铱-亚磷酰胺络合物催化的非手性烯丙基酯的区域和对映选择性烯丙基胺化

  摘要：

  通过探索手性亚磷酰胺的配合物，开发了一种新的催化不对称过程，即铱催化的 (E)-肉桂基和末端脂肪族烯丙基碳酸酯的对映选择性烯丙基胺化。该反应以高产率提供支链仲胺和叔烯丙胺，具有出色的区域选择性和对映选择性（13 个实例超过 94% ee）。尽管在极性溶剂如 DMF、EtOH 和 MeOH 中的反应速度很快，但它们的对映体过量率很低。相比之下，THF 中的反应显示出最合适的速率和对映选择性平衡。亚磷酰胺中的联萘单元和二取代胺均影响反应性和选择性，以及 O,O'-(R)-(1,1'-二萘基-2,2'-二基)-N,N'-di 的配合物-(R, R)-1-苯基乙基亚磷酰胺提供了最高的反应性和选择性。伯胺和环状仲胺在室温下反应，无环二乙胺在 50 摄氏度下反应。对甲氧基取代的肉桂基碳酸酯与未取代的肉桂基碳酸酯的反应类似，但邻甲氧基取代的底物产生较低的对映体过量。对于呋喃基-和烷基-取代的(E)-烯丙基碳酸酯反应的产物，也观察到高ee。

  DOI：

  10.1021/ja028614m

文献信息

• Enantioselective amination and etherification
  申请人：Hartwig F John

  公开号：US20060199728A1

  公开（公告）日：2006-09-07

  The present invention is directed to a catalyst composition, comprising: (1) a catalyst precursor having the general structure MSX n wherein M is a transition metal selected from the group consisting of iridium, molybdenum, and tungsten; S is a coordinating ligand; X is a counterion; and n is an integer from 0 to 5; and (2) a phosphoramidite ligand having the structure wherein O—C n —O is an aliphatic or aromatic diolate and wherein R 1 , R 2 , R 3 and R 4 are selected from the group consisting of substituted or unsubstituted aryl groups, substituted or unsubstituted heteroaryl groups, substituted or unsubstituted aliphatic groups, and combinations thereof, with the proviso that at least one of R 1 , R 2 , R 3 , or R 4 must be a substituted or unsubstituted aryl or heteroaryl group. The present invention is also directed to activated catalysts made from the above catalyst composition, as well as methods of allylic amination and etherification using the above catalysts.

  本发明涉及一种催化剂组合物，包括：（1）具有一般结构MSXn的催化剂前体，其中M是从铱、钼和钨组成的过渡金属中选择的；S是一个配位配体；X是一个计数离子；n是从0到5的整数；以及（2）具有以下结构的磷酰胺配体，其中O-Cn-O是脂肪族或芳香族二醇，其中R1、R2、R3和R4选自取代或未取代的芳基基团、取代或未取代的杂环基团、取代或未取代的脂肪基团和它们的组合，但至少有一个R1、R2、R3或R4必须是取代或未取代的芳基或杂环基团。本发明还涉及由上述催化剂组合物制备的活性催化剂，以及使用上述催化剂进行烯丙基胺化和醚化的方法。
• Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders
  申请人：Balestra Michael

  公开号：US20090069340A1

  公开（公告）日：2009-03-12

  Compounds of Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.

  公式（I）的化合物，其中R1，R2，R3，R4，R5，R6，X和n的定义如描述中的公式（I），制备该化合物的过程以及用于制备的新中间体，含有该化合物的制药组合物以及在治疗或预防与谷氨酸功能障碍有关的神经系统和精神障碍中使用该化合物。
• PIPERIDINE DERIVATIVE, PIPERAZINE DERIVATIVE AND AGENT FOR TREATMENT OF DISEASE INVOLVING CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Mita Shiro

  公开号：US20110263862A1

  公开（公告）日：2011-10-27

  A novel piperidine derivative and a novel piperazine derivative which are useful as novel sigma receptor ligands, and an agent for treatment of diseases involving a central nervous system disorders, said agent containing one of the compound as an active ingredient. The agent contains a compound represented by general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: wherein X represents an alkylene group having 1 to 5 carbon atoms, and the alkylene group may be substituted by one or more alkyl groups each having 1 to 2 carbon atoms; Y represents a carbon atom or a nitrogen atom; and R1 and R2 each independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 2 carbon atoms or an alkoxy group having 1 to 2 carbon atoms.

  一种新型哌啶衍生物和一种新型哌嗪衍生物，可用作新型σ受体配体，以及一种用于治疗涉及中枢神经系统疾病的药剂，该药剂含有其中一种化合物作为活性成分。该药剂含有以下通式（I）所表示的化合物或其药学上可接受的盐作为活性成分：其中，X代表具有1至5个碳原子的烷基，该烷基可以被一个或多个具有1至2个碳原子的烷基取代；Y代表碳原子或氮原子；R1和R2各自独立地代表氢原子、卤素原子、具有1至2个碳原子的烷基或具有1至2个碳原子的烷氧基。
• Polymodal conjugated diolefin vinyl aromate rubber composition
  申请人：JSR Corporation

  公开号：EP1000970A1

  公开（公告）日：2000-05-17

  A conjugated diolefin copolymer rubber and a rubber composition which can produce vulcanized products exhibiting well-balanced improved properties such as wet skid properties, low hysteresis loss properties, abrasion resistance, and breaking strength irrespective of the types and combinations of fillers to be added, and is useful as a tread material for low fuel consumption tires, large tires, and high performance tires. A conjugated diolefin copolymer rubber is prepared by the copolymerization of a conjugated diolefin and a vinyl aromatic compound, and (1) has a content of the bonded vinyl aromatic compound of 5-50 wt%, (2) contains 0.01-5.0 mmol of an alkoxysilyl group having substantially non-hydrolyzable Si-O-R bond (wherein R indicates a hydrocarbon group having 4-20 carbon atoms) and 0.01-2.0 mmol of a tin-carbon bond for 100 g of the copolymer rubber, and (3) has a polymodal-type molecular weight distribution.

  一种共轭二烯烃共聚物橡胶和一种橡胶组合物，无论添加填料的类型和组合如何，都能生产出均衡改善性能的硫化产品，如湿滑性能、低滞后损失性能、耐磨性和断裂强度，可用作低油耗轮胎、大型轮胎和高性能轮胎的胎面材料。共轭二烯烃共聚橡胶由共轭二烯烃和乙烯基芳香化合物共聚制备而成，(1) 键合乙烯基芳香化合物的含量为 5-50 wt%，(2) 含有 0.01-5.0毫摩尔具有基本上不可水解的Si-O-R键的烷氧基硅基（其中R表示具有4-20个碳原子的烃基）和0.01-2.0毫摩尔的锡-碳键的共聚橡胶，以及（3）具有多模态型分子量分布。
• Oil extended rubber and rubber composition
  申请人：JSR Corporation

  公开号：EP0992537A1

  公开（公告）日：2000-04-12

  An oil extended rubber comprising 100 parts by weight of (A) an amino group-containing copolymer rubber of a conjugated diolefin and an aromatic vinyl compound which contains bonded amino groups in the amount of 0.0025-0.20 mmol/g polymer, and 10-100 parts by weight of (B) an extensible oil. Carbon black, silica, a mixture of carbon black and silica, or a carbon-silica dual-phase-filler can be homogeneously dispersed in the oil extended rubber. Vulcanized products obtained by vulcanizing the rubber exhibits well-balanced improved properties such as wet skid properties, low hysteresis loss properties, abrasion resistance, and breaking strength, and are useful as a tread material for low fuel consumption tires, large tires, and high performance tires.

  一种油延橡胶，由 100 重量份的(A)共轭二烯烃和芳香族乙烯基化合物的含氨基的共聚橡胶和 10-100 重量份的(B)延展性油组成，(A)共轭二烯烃和芳香族乙烯基化合物的含氨基的共聚橡胶含有键合氨基的量为 0.0025-0.20 mmol/g，(B)延展性油含有键合氨基的量为 0.0025-0.20 mmol/g。碳黑、白炭黑、碳黑和白炭黑混合物或碳硅双相填料可均匀地分散在延展性油橡胶中。通过硫化橡胶得到的硫化产品具有均衡的改良特性，如湿滑特性、低滞后损失特性、耐磨性和断裂强度，可用作低油耗轮胎、大型轮胎和高性能轮胎的胎面材料。