1-(2,2-二乙氧基乙基)-4-氟苯 | 1743-98-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2,2-二乙氧基乙基)-4-氟苯
• 英文名称: 1-(2,2-Diethoxyethyl)-4-fluorobenzene
• CAS: 1743-98-2
• 化学式: C₁₂H₁₇FO₂
• mdl: MFCD11554373
• 分子量: 212.26
• InChiKey: KHBPNUUPZGUYDW-UHFFFAOYSA-N

物化性质

• 沸点：
  78-80 °C(Press: 3.5 Torr)
• 密度：
  1.032±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Indole derivatives for the treatment of depression and anxiety
  申请人：——

  公开号：US20040006229A1

  公开（公告）日：2004-01-08

  The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. 1

  本发明提供了以下化合物的公式（I）：这些化合物对治疗抑郁症、焦虑症，并缓解因戒烟或部分戒烟引起的症状非常有用。
• [EN] INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY<br/>[FR] DERIVES DE L'INDOLE DESTINES AU TRAITEMENT DE DEPRESSION ET D'ANXIETE
  申请人：LILLY CO ELI

  公开号：WO2001046181A1

  公开（公告）日：2001-06-28

  The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

  本发明提供了式(I)的化合物，该化合物对于治疗抑郁症、焦虑症以及减轻戒烟或尼古丁部分戒断引起的症状是有用的。
• Benzothiophenes, their production and use, and compositions containing them
  申请人：Merck & Co., Inc.

  公开号：EP0160408A1

  公开（公告）日：1985-11-06

  N-Alkenyl-3-hydroxybenzo [b] thiophene-2-carboxamide derivatives of formula) and their pharmaceutically acceptable salts, are novel. In the formula, each of R, R1, R2, R3 and R4 is selected from various hydrocarbons (including heteroaryl), acyl, and acyl- substituted hydrocarbon groups and their ring-substituted derivatives; or R1, R2 and R3 can be halo, or R' and R2 joined to form certain tricyclic bivalent residues, or R4 is -CR1=CR2R3, and n is 0, 1, or 2. These compounds are prepared by (1) treating a substituted 2-halobenzoate with thioacetamide followed by N-alkenylation with appropriate agents, such as aldehydes, ketones, enol ethers, epoxides, acetals or ketals; (2) treating a substituted thiosalicylate with an appropriately substituted halocetamide, followed by dehydration; and (3) further synthetic modification of compounds prepared above. These compounds have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and thereby useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory bowel disease, glaucoma or other prostaglandins and/or leukotriene mediated diseases. Furthermore, these compounds have been found to exhibit cytoprotective activity which does not involve the inhibition of gastric acid secretion but can be used as relatively low dosages for increasing the resistance of gastro-intestinal mucosa to strong irritants. They are included in pharmaceutical compositions.

  式）的 N-烯基-3-羟基苯并[b]噻吩-2-甲酰胺衍生物及其药学上可接受的盐是新颖的。 及其药学上可接受的盐类是新型的。式中，R、R1、R2、R3 和 R4 各选自各种烃（包括杂芳基）、酰基和酰基取代的烃基及其环取代衍生物；或者 R1、R2 和 R3 可以是卤代物，或者 R' 和 R2 连接形成某些三环二价残基，或者 R4 是-CR1＝CR2R3，n 是 0、1 或 2。这些化合物的制备方法是：(1) 用硫代乙酰胺处理取代的 2-卤代苯甲酸酯，然后用适当的制剂（如醛、酮、烯醇醚、环氧化物、乙醛或酮）进行 N-烯化；(2) 用适当取代的卤代乙酰胺处理取代的硫代水杨酸酯，然后脱水；(3) 对上述制备的化合物进行进一步合成修饰。 已发现这些化合物是环氧化酶和脂氧合酶的有效抑制剂，因此可用于治疗疼痛、发热、炎症、关节炎、哮喘、过敏性疾病、皮肤病、心血管疾病、牛皮癣、炎症性肠病、青光眼或其他前列腺素和/或白三烯介导的疾病。此外，这些化合物 还具有细胞保护活性，这种活性不涉及抑制胃酸分泌，但剂量相对较低，可用于增强胃肠道粘膜对强刺激物的抵抗力。它们已被纳入药物组合物中。
• Verfahren zur Herstellung von Arylacetaldehyddialkylacetalen
  申请人：HÜLS AKTIENGESELLSCHAFT

  公开号：EP0403841B1

  公开（公告）日：1993-08-04
• INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY
  申请人：ELI LILLY AND COMPANY

  公开号：EP1242411B1

  公开（公告）日：2006-03-08