1-(2,4-二硝基苯基)-4-苯基哌嗪 | 62208-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2,4-二硝基苯基)-4-苯基哌嗪
• 英文名称: 1-(2,4-dinitro-phenyl)-4-phenyl-piperazine
• 英文别名: 1-(2,4-Dinitro-phenyl)-4-phenyl-piperazin；Piperazine, 1-(2,4-dinitrophenyl)-4-phenyl-；1-(2,4-dinitrophenyl)-4-phenylpiperazine
• CAS: 62208-64-4
• 化学式: C₁₆H₁₆N₄O₄
• 分子量: 328.327
• InChiKey: MZXWFRXXNQJHNL-UHFFFAOYSA-N

物化性质

• 沸点：
  529.6±50.0 °C(Predicted)
• 密度：
  1.364±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  98.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-苯基哌嗪 、 1-氯-2,4-二硝基苯 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以95%的产率得到1-(2,4-二硝基苯基)-4-苯基哌嗪
  参考文献：
  名称：

  2H-Benzimidazole 1,3-Dioxide Derivatives:  A New Family of Water-Soluble Anti-Trypanosomatid Agents

  摘要：

  Three series of benzimidazole N-oxide derivatives were developed and were examined for their activity against trypanosomatid parasites (Trypanosoma cruzi and Leishmania spp.). 2H-Benzimidazole 1,3-dioxides displayed remarkable in vitro activities against both parasites, with derivatives 28, 29, and 32 being the most potent (IC50 < 5 mu M) against the epimastigote form of T. cruzi and 28, 33, and 35 the most potent against the promastigote form of Leishmania spp. Unspecific cytotoxicity was evaluated using murine macrophages, and derivative 33 was not toxic at a concentration 30 times that of its IC50 against T. cruzi that was completely toxic for Leishmania spp., implying that the series of 2H-benzimidazole 1,3-dioxides is selective toward both trypanosomatid parasites. Derivatives 33 and 35 were submitted to an in vivo assay using an acute model of Chagas' disease and a short-term treatment (30 mg/kg/day orally administrated as aqueous solution, during 10 days). While in the control (untreated) and Benznidazole (50 mg/kg/day) groups survival fraction was 60.0% and 87.5%, respectively, none of the animals treated with derivatives 33 and 35 died. From the preliminary structure-activity relationship studies reduction potential and electrophilicity were found relevant to anti-T. cruzi activity. Active compounds are better electrophiles and more easily reduced than inactive ones.

  DOI：

  10.1021/jm0600343

文献信息

• Prelog; Blazek, Collection of Czechoslovak Chemical Communications, 1934, vol. 6, p. 549,555
  作者：Prelog、Blazek

  DOI：——

  日期：——
• 2<i>H</i>-Benzimidazole 1,3-Dioxide Derivatives:  A New Family of Water-Soluble Anti-Trypanosomatid Agents
  作者：Mariana Boiani、Lucía Boiani、Ana Denicola、Susana Torres de Ortiz、Elva Serna、Ninfa Vera de Bilbao、Luis Sanabria、Gloria Yaluff、Héctor Nakayama、Antonieta Rojas de Arias、Celeste Vega、Miriam Rolan、Alicia Gómez-Barrio、Hugo Cerecetto、Mercedes González

  DOI：10.1021/jm0600343

  日期：2006.6.1

  Three series of benzimidazole N-oxide derivatives were developed and were examined for their activity against trypanosomatid parasites (Trypanosoma cruzi and Leishmania spp.). 2H-Benzimidazole 1,3-dioxides displayed remarkable in vitro activities against both parasites, with derivatives 28, 29, and 32 being the most potent (IC50 < 5 mu M) against the epimastigote form of T. cruzi and 28, 33, and 35 the most potent against the promastigote form of Leishmania spp. Unspecific cytotoxicity was evaluated using murine macrophages, and derivative 33 was not toxic at a concentration 30 times that of its IC50 against T. cruzi that was completely toxic for Leishmania spp., implying that the series of 2H-benzimidazole 1,3-dioxides is selective toward both trypanosomatid parasites. Derivatives 33 and 35 were submitted to an in vivo assay using an acute model of Chagas' disease and a short-term treatment (30 mg/kg/day orally administrated as aqueous solution, during 10 days). While in the control (untreated) and Benznidazole (50 mg/kg/day) groups survival fraction was 60.0% and 87.5%, respectively, none of the animals treated with derivatives 33 and 35 died. From the preliminary structure-activity relationship studies reduction potential and electrophilicity were found relevant to anti-T. cruzi activity. Active compounds are better electrophiles and more easily reduced than inactive ones.