1-(2-巯基乙基)吡咯烷-2-酮 | 13839-15-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(2-巯基乙基)吡咯烷-2-酮
• 英文名称: 1-(2-mercapto-ethyl)-pyrrolidin-2-one
• 英文别名: 1-(2-Mercapto-aethyl)-pyrrolidin-2-on；N-(β-mercaptoethyl)-2-pyrrolidone；N-(2-Mercaptoethyl)-pyrrolidone；N-mercaptoethyl pyrrolidone；1-<2-Mercaptoethyl>-2-pyrrolidon；1-(2-Mercaptoethyl)pyrrolidin-2-one；1-(2-sulfanylethyl)pyrrolidin-2-one
• CAS: 13839-15-1
• 化学式: C₆H₁₁NOS
• 分子量: 145.225
• InChiKey: JBODMFWMIWWZSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

反应信息

• 作为产物：
  描述：

  1-(2-氯乙基)吡咯烷-2-酮 在 sodium hydrogensulfide 、 水 作用下， 生成 1-(2-巯基乙基)吡咯烷-2-酮
  参考文献：
  名称：

  Schostakowskii et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 68,70; engl. Ausg. S. 60, 62.

  摘要：

  DOI：

文献信息

• Method for preparing free-flowing crystalline material
  申请人：Cook Lee William

  公开号：US20050288527A1

  公开（公告）日：2005-12-29

  An improved process for making a high purity, crystalline aromatic dicarboxylic acid product which includes at least one step for crystallizing the product and wherein the crystallized product is thereafter subjected to a drying step. The improved process further includes the steps of storing the crystallized product for a period of time sufficient for at least a portion of residual solvent carried with the dried crystallized product to reside on a surface of the crystalline product; and contacting the stored crystallized product with an inert fluid for a time sufficient to remove at least a portion of the residual solvent in the stored crystallized product. Purified crystalline aromatic dicarboxylic acids suitable for the present improved process include benzene dicarboxylic acid, naphthalene dicarboxylic acid, bibenzoic acid, terephthalic acid, and isophthalic acid. Particularly preferred aromatic dicarboxylic acids include terephthalic acid, and isophthalic acid.

  一种改进的制备高纯度、结晶芳香族二羧酸产物的方法，其中包括至少一步结晶产物的步骤，并且结晶的产物随后经过干燥步骤。改进的方法还包括将结晶的产物存储一段时间，足以使得干燥的结晶产物携带的残留溶剂的至少一部分停留在结晶产物的表面上；并将存储的结晶产物与惰性流体接触一段时间，足以去除存储的结晶产物中的至少一部分残留溶剂。适用于本改进方法的纯化的结晶芳香族二羧酸包括苯二羧酸、萘二羧酸、二苯甲酸、对苯二甲酸和间苯二甲酸。特别优选的芳香族二羧酸包括对苯二甲酸和间苯二甲酸。
• Speed increasing adjuvant containing silver halide emulsions
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0091212A1

  公开（公告）日：1983-10-12

  Derivatives of thiazolidine are used in photographic silver halide emulsions to increase their speed 40% or more with little or no increase in emulsion fog. Lower silver halide coating weights are thus possible.

  在照相卤化银乳剂中使用噻唑烷的衍生物，可将乳剂的速度提高 40% 或更多，而乳剂的雾度几乎不会增加。因此可以降低卤化银涂层的重量。
• Composition and method for corrosion inhibition
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0176990A1

  公开（公告）日：1986-04-09

  A composition is provided which, when applied to a metal surface, forms a corrosion-inhibiting film thereon. The composition comprises the reaction product of a first component selected from an epoxy resin, an epoxidized alkene and a substrate having at least one displaceable halogen, and a second component comprising a monomercaptan in a hydrocarbon diluent. The composition is applied by contacting the metal surface with the composition. The composition is particularly useful in the treatment of down- well metal surfaces in oil and gas wells to inhibit the corrosion of the metal under highly corrosive conditions, and is effective even in the presence of polymeric permeability control agents such as aqueous polyacrylamides.

  本发明提供了一种组合物，当应用于金属表面时，可在其上形成一层腐蚀抑制膜。 该组合物包括选自环氧树脂、环氧化烯和具有至少一种可置换卤素的基质的第一组分与包括烃类稀释剂中的单硫醇的第二组分的反应产物。 通过将金属表面与该组合物接触来应用该组合物。 该组合物特别适用于处理油气井中的井下金属表面，以抑制金属在高腐蚀性条件下的腐蚀，即使在存在聚合物渗透性控制剂（如水性聚丙烯酰胺）的情况下也有效。
• MITOCHONDRIAL MEMBRANE STABILIZER
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0953356A1

  公开（公告）日：1999-11-03

  An medicament for preventive and/or therapeutic treatment of a disease caused by mitochondrial functional abnormality, or a disease with mitochondrial functional abnormality, e.g., ischemic diseases, toxic diseases, degenerative diseases, which comprises as an active ingredient a substance having a stabilizing effect on mitochondrial membrane by stabilizing mitochondrial membrane potential, e.g., 2-oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide which acts as a benzodiazepine receptor antagonist.

  一种用于预防和/或治疗由线粒体功能异常引起的疾病或线粒体功能异常疾病（如缺血性疾病、中毒性疾病、退行性疾病）的药物，其活性成分包括通过稳定线粒体膜电位对线粒体膜具有稳定作用的物质，如线粒体膜电位稳定剂、 一种用于预防和/或治疗由线粒体功能异常引起的疾病或具有线粒体功能异常的疾病（如缺血性疾病、中毒性疾病、退行性疾病）的药物，其有效成分包括通过稳定线粒体膜电位对线粒体膜具有稳定作用的物质，如作为苯并二氮杂卓受体拮抗剂的 2-氧代-1-吡咯烷基乙酸 2,6-二甲基苯胺。
• NOOTROPIC AGENT
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1022029A1

  公开（公告）日：2000-07-26

  A drug which improves cerebral neurotransmission based on interaction of long-term activation of a protein kinase C pathway and long-term activation of presynaptic nicotinic acetylcholine (nACh) receptors, and on an accompanying increase in the amount of released glutamate, which activates cerebral neurotransmission over a prolonged period. The substances of the present invention serve as excellent nootropics. They are particularly useful for the therapy of dementia caused by hydrocephalus, or by subdural hemorrhage.

  一种基于长期激活蛋白激酶 C 途径和长期激活突触前烟碱乙酰胆碱（nACh）受体的相互作用，以及伴随的谷氨酸释放量的增加而改善脑神经递质的药物，可长期激活脑神经递质。本发明的物质是一种极好的促智剂。它们尤其适用于治疗由脑积水或硬脑膜下出血引起的痴呆症。