[EN] ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS<br/>[FR] DERIVES AMINOALKYLIMIDAZOLE FUSIONNES ARYLE ET HETEROARYLE: MODULATEURS SELECTIFS DE RECEPTEURS GABAA
申请人:NEUROGEN CORP
公开号:WO2000059905A1
公开(公告)日:2000-10-12
Disclosed are compounds of formula (I), or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs, and enhancement of memory and alertness.