1-(2-溴乙基)-2,3,4-三氟苯 | 887586-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2-溴乙基)-2,3,4-三氟苯
• 英文名称: 1-(2-Bromoethyl)-2,3,4-trifluorobenzene
• CAS: 887586-25-6
• 化学式: C₈H₆BrF₃
• 分子量: 239.03
• InChiKey: ODZDQVMPZAEHOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Hydrogenated phenanthrenes and their use in liquid-crystal mixture
  申请人：Merck Patent GmbH

  公开号：US20020049348A1

  公开（公告）日：2002-04-25

  The invention concerns hydrogenated phenanthrenes of formula I 1 wherein the parameters have the meanings given in the text and their use in liquid crystal compositions.

  本发明涉及公式I1的氢化菲的化合物，其中参数的含义如文本所述，并且它们在液晶组合物中的应用。
• Hydrierte Phenanthrene und ihre Verwendung in Flüssigkristallmischungen
  申请人：MERCK PATENT GmbH

  公开号：EP1162185B1

  公开（公告）日：2003-10-01
• DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME
  申请人：Ardea Biosciences, Inc.

  公开号：EP2184984A1

  公开（公告）日：2010-05-19
• US6515163B2
  申请人：——

  公开号：US6515163B2

  公开（公告）日：2003-02-04
• [EN] DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME<br/>[FR] DÉRIVÉS DE N-(ARYLAMINO)ARYLSULFONAMIDE COMPRENANT DES POLYMORPHES EN TANT QU'INHIBITEURS DE MEK AINSI QUE COMPOSITIONS, PROCÉDÉS D'UTILISATION ET PROCÉDÉS DE PRÉPARATION DE CEUX-CI
  申请人：ARDEA BIOSCIENCES INC

  公开号：WO2009018233A1

  公开（公告）日：2009-02-05

  This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compunds and compositions described herein.