N-(4-bromophenyl)-4-ethylpiperazine-1-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-bromophenyl)-4-ethylpiperazine-1-carboxamide
• 化学式: C₁₃H₁₈BrN₃O
• mdl: MFCD05081486
• 分子量: 312.21
• InChiKey: HLFJFRFYNODTOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
  申请人：Deutsches Krebsforschungszentrum

  公开号：EP3992191A1

  公开（公告）日：2022-05-04

  The present invention relates to imidazo[4,5-c]quinoline compounds and to their use in the inhibition, regulation and/or modulation of signal transduction by ATM kinase and, in particular, for the treatment of ATM mediated diseases, especially cancer.

  本发明涉及咪唑[4,5-c]喹啉化合物及其在ATM激酶信号转导的抑制、调节和/或调节中的使用，特别是用于治疗ATM介导的疾病，尤其是癌症。
• [EN] IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS<br/>[FR] COMPOSÉS IMIDAZO[4,5-C]QUINOLÉINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASE ATM
  申请人：[en]DEUTSCHES KREBSFORSCHUNGSZENTRUM

  公开号：WO2022096361A1

  公开（公告）日：2022-05-12

  The present invention relates to imidazo[4,5-c]quinoline compounds and to their use in the inhibition, regulation and/or modulation of signal transduction by ATM kinase and, in particular, for the treatment of ATM mediated diseases, especially cancer.