2-(3-Methylphenyl)-1-(4-methylpiperazin-1-yl)ethanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Methylphenyl)-1-(4-methylpiperazin-1-yl)ethanone
• 化学式: C₁₄H₂₀N₂O
• 分子量: 232.32
• InChiKey: PTVJDHHEJBPZNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SUBSTITUTED UREA EIF2α KINASE ACTIVATORS<br/>[FR] ACTIVATEURS SUBSTITUÉS DE L'URÉE-KINASE EIF2&Agr;
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2015038778A1

  公开（公告）日：2015-03-19

  This disclosure relates to substituted urea eIF2α kinase activators including methods of making and using the same. For example, such activators can include cycloalkyl aryl ureas, which activate at least one eIF2α kinase. These compounds may be useful for treatment of diseases such as, for example, cancer, hemolytic anemia not caused by infectious agents, Wolcott-Rallison syndrome, neurodegenerative disease, tuberous sclerosis complex, fragile-X syndrome, autism spectrum disorder, and ribosomal defect disease.

  本公开涉及替代脲eIF2α激酶激活剂，包括其制备和使用方法。例如，这些激活剂可以包括环烷基芳基脲，其激活至少一种eIF2α激酶。这些化合物可能对治疗疾病有用，例如癌症、非感染性溶血性贫血、沃尔科特-拉里森综合征、神经退行性疾病、结节性硬化症、脆性X综合征、自闭症谱系障碍和核糖体缺陷疾病。
• N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
  申请人：Aktas Bertal Huseyin

  公开号：US20120115915A1

  公开（公告）日：2012-05-10

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

  本文提供了抑制翻译起始的组合物和方法。描述了使用N，N'-二芳基脲和/或N，N'-二芳基硫脲化合物治疗（1）细胞增生性疾病，（2）非增生性退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。
• INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS
  申请人：Merck Serono S.A.

  公开号：EP2655357B1

  公开（公告）日：2016-06-22
• POLYARYLETHER COMPOSITIONS BEARING ZWITTERION FUNCTIONALITIES
  申请人：Zhang Yanshi

  公开号：US20100044314A1

  公开（公告）日：2010-02-25

  A method for making a polysulfone having zwitterionic functionality comprising reacting a piperazine amine functionalized polysulfone with sultone is described as are blends with other polymers. Membranes containing polysulfones having zwitterionic functionality are also provided. Membranes thus formed are used in hemodialysis, hemofiltration, and water purification.
• Substituted Urea eIF2alpha Kinase Activators
  申请人：THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

  公开号：US20160318856A1

  公开（公告）日：2016-11-03

  This disclosure relates to substituted urea eIF2α kinase activators including methods of making and using the same. For example, such activators can include cycloalkyl aryl ureas, which activate at least one eIF2α kinase. These compounds may be useful for treatment of diseases such as, for example, cancer, hemolytic anemia not caused by infectious agents, Wolcott-Rallison syndrome, neurodegenerative disease, tuberous sclerosis complex, fragile-X syndrome, autism spectrum disorder, and ribosomal defect disease.