1-(2-脱氧-beta-L-赤式-呋喃戊糖基)-5-(甲基氨基)-2,4(1H,3H)-嘧啶二酮 | 840-50-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 中文名称: 1-(2-脱氧-beta-L-赤式-呋喃戊糖基)-5-(甲基氨基)-2,4(1H,3H)-嘧啶二酮
• 英文名称: 2-Deoxy-5-(methylamino)uridine
• 英文别名: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(methylamino)pyrimidine-2,4-dione
• CAS: 840-50-6
• 化学式: C₁₀H₁₅N₃O₅
• 分子量: 257.24
• InChiKey: KPQFKCWYCKXXIP-XLPZGREQSA-N

物化性质

• 熔点：
  180-182°

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  111
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] METHODS OF REDUCING TOXICITY OF CHEMOTHERAPEUTIC AND ANTIVIRAL AGENTS WITH ACYLATED PYRIMIDINE NUCLEOSIDES<br/>[FR] PROCEDES DE REDUCTION DE LA TOXICITE D'AGENTS CHIMIOTHERAPEUTIQUES ET ANTIVIRAUX AVEC DES NUCLEOSIDES DE PYRIMIDE ACYLES
  申请人：PRO-NEURON, INC.

  公开号：WO1996040165A1

  公开（公告）日：1996-12-19

  (EN) The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.(FR) La présente invention se rapporte à des composés, des compositions et des procédés de traitement et de prévention de la toxicité due à des agents chimiothérapeutiques et antiviraux. L'invention se rapporte également à des dérivés acylés de nucléosides de pyrimidine non méthylés. Ces composés peuvent atténuer les lésions du système hématopoïétique chez des animaux subissant une chimiothérapie antivirale ou antinéoplasique.

  该发明涉及用于治疗和预防化疗药物和抗病毒药物引起的毒性的化合物、组合物和方法。揭示了非甲基化嘧啶核苷酸的酰化衍生物。这些化合物能够减轻接受抗病毒或抗肿瘤化疗的动物的造血系统损伤。
• TREATMENT OF CHEMOTHERAPEUTIC AGENT AND ANTIVIRAL AGENT TOXICITY WITH ACYLATED PYRIMIDINE NUCLEOSIDES
  申请人：——

  公开号：US20010025032A1

  公开（公告）日：2001-09-27

  The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.

  本发明涉及化合物、组合物和治疗及预防化疗药物和抗病毒药物毒性的方法。本发明揭示了非甲基嘧啶核苷酸的酰化衍生物。这些化合物能够减轻接受抗病毒或抗肿瘤化疗的动物的造血系统损伤。
• Modified labeled nucleotides and polynucleotides and methods of preparing, utilizing and detecting same
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0097373A2

  公开（公告）日：1984-01-04

  Nucleotides and polynucleotides, including DNA, are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material.

  核苷酸和多核苷酸（包括 DNA）经过化学修饰或标记，当附着在核酸材料上和/或掺入核酸材料中时，可随时进行检测。
• A drug delivery conjugate
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0285950A2

  公开（公告）日：1988-10-12

  Nucleotides and polynucleotides, including DNA, are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material.

  核苷酸和多核苷酸（包括 DNA）经过化学修饰或标记，当附着在核酸材料上和/或掺入核酸材料中时，可随时进行检测。
• Protein with a moiety capable of chelating ions attached thereto
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0618228A1

  公开（公告）日：1994-10-05

  Disclosed is a protein to which a moiety capable of chelating an ion is directly or indirectly attached, said attachment being characterized in not interfering substantially with the ability of the moiety to chelate ions.

  本发明公开了一种蛋白质，其上直接或间接附着有能够螯合离子的分子，所述附着物的特点是不会严重干扰分子螯合离子的能力。