1-(3-吖丁啶基)吖丁啶 | 928114-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 中文名称: 1-(3-吖丁啶基)吖丁啶
• 英文名称: (azetidin-3-yl)azetidin
• 英文别名: 1,3'-biazetidine；1,3'-biazetidin；1-(azetidin-3-yl)azetidine
• CAS: 928114-07-2
• 化学式: C₆H₁₂N₂
• 分子量: 112.175
• InChiKey: SQGAMWPLHIDBLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(azetidin-1-yl)-1-benzhydrylazetidine 在 5%-palladium/activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 生成 1-(3-吖丁啶基)吖丁啶
  参考文献：
  名称：

  PYRIMIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF

  摘要：

  公开号：

  EP3216786B1

文献信息

• Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones
  申请人：Armour R. Duncan

  公开号：US20080085884A1

  公开（公告）日：2008-04-10

  The present invention provides for MCHR1 antagonist compounds of formula (I) and the pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein the substituents are as defined herein, and the pharmaceutically acceptable salts, solvates and prodrugs thereof, which are useful in treating diseases or conditions wherein antagonism of the MCHR1 receptor is beneficial.

  本发明提供了式（I）的MCHR1拮抗剂化合物及其药用盐、溶剂合物和前药，其中取代基如本文所定义，并且其药用盐、溶剂合物和前药，可用于治疗对MCHR1受体拮抗有益的疾病或症状。
• Process for preparing phenoxypyridine derivatives
  申请人：Nagai Mitsuo

  公开号：US20080214815A1

  公开（公告）日：2008-09-04

  A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R 1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R 2 , R 3 , R 4 and R 5 may be the same or different and each represents hydrogen or fluorine; and R 6 represents hydrogen or fluorine.

  制备一种由化学式(I)表示的化合物的方法： 包括将由化学式(II)表示的化合物或其盐： 与由化学式(III)表示的化合物： 在缩合试剂的存在下反应， 其中R 1 代表1）可选择地取代的氮杂环丙烷-1-基，2）可选择地取代的吡咯烷-1-基，3）可选择地取代的哌啶-1-基等；R 2 ，R 3 ，R 4 和R 5 可以相同也可以不同，每个代表氢或氟；而R 6 代表氢或氟。
• 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME
  申请人：Hopper Allen

  公开号：US20110092475A1

  公开（公告）日：2011-04-21

  The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R 1 , R 2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.

  本发明提供了公式（I）的2-取代-乙炔基噻唑衍生物：其中R1、R2和X如此处定义，或其药学上可接受的盐；以及使用相同的药物组合物和方法。
• [EN] COMPOUNDS AS RAS INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS EN TANT QU'INHIBITEURS DE RAS ET LEURS UTILISATIONS
  申请人：BIOARDIS LLC

  公开号：WO2022087624A1

  公开（公告）日：2022-04-28

  The present disclosure relates generally to compounds and compositions thereof for inhibition of RAS, such as KRAS, HRAS and NRAS, including mutant forms of KRAS, HRAS and NRAS, particularly those harboring a G12C mutation, methods of preparing said compounds and compositions, and their use in the treatment or prophylaxis of various cancers, such as lung cancer, colorectal cancer, pancreatic cancer, gall bladder cancer, thyroid cancer, and bile duct cancer.

  本公开涉及抑制RAS的化合物和其组成物，例如KRAS、HRAS和NRAS，包括带有G12C突变的KRAS、HRAS和NRAS的突变形式，制备这些化合物和组合物的方法，以及它们在治疗或预防各种癌症方面的用途，例如肺癌、结直肠癌、胰腺癌、胆囊癌、甲状腺癌和胆管癌。
• Novel pyridine derivatives and pyrimidine derivatives (3)
  申请人：Matsushima Tomohiro

  公开号：US20080319188A1

  公开（公告）日：2008-12-25

  A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R 1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R 2 and R 3 represent hydrogen; R 4 , R 5 , R 6 , and R 7 may be the same or different and each represents hydrogen, halogen, C 1-6 alkyl or the like; R 8 represents hydrogen or the like; R 9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH═, nitrogen or the like.]

  以下化合物，其盐或水合物，具有优异的肝细胞生长因子受体（HGFR）抑制活性，表现出抗肿瘤活性、抑制血管生成活性和癌症转移抑制活性。[其中，R1代表3-至10-成员的非芳香族杂环基团等；R2和R3代表氢；R4、R5、R6和R7可以相同或不同，每个代表氢、卤素、C1-6烷基或类似物；R8代表氢或类似物；R9代表3-至10-成员的非芳香族杂环基团等；n代表1或2的整数；X代表-CH═，氮或类似物。]