2-(2-Aminoethyl)benzenesulfonyl fluoride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-Aminoethyl)benzenesulfonyl fluoride
• 化学式: C₈H₁₀FNO₂S
• 分子量: 203.24
• InChiKey: TZJAEGCLMLTGRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] INHIBITORS OF CHECKPOINT KINASES<br/>[FR] INHIBITEURS DE CHECKPOINT KINASES
  申请人：MERCK & CO INC

  公开号：WO2009102537A1

  公开（公告）日：2009-08-20

  The instant invention provides for compounds which comprise substituted thioquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.

  这项即时发明提供了包含替代硫喹唑酮的化合物，这些化合物抑制CHK1活性。该发明还提供了包含这种抑制性化合物的组合物，以及通过向需要癌症治疗的患者施用该化合物来抑制CHK1活性的方法。
• COMPOSITIONS AND METHODS FOR BIOLOGICAL SAMPLE STORAGE
  申请人：Whitney Scott E.

  公开号：US20110081363A1

  公开（公告）日：2011-04-07

  Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.

  本发明公开了一种用于在常温或升高温度下实现生物样品（如核酸、蛋白质和细胞）的基本干燥储存的组合物和方法，所述生物样品可以在其中以基本恢复的形式被恢复，使用可溶解或可分解的干燥储存基质，该基质包含硼酸盐组合物和稳定剂，例如多种带电离的稳定剂之一。
• [EN] INHIBITORS OF AKT ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITÉ D'AKT
  申请人：MERCK SHARP & DOHME

  公开号：WO2010088177A1

  公开（公告）日：2010-08-05

  The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

  本发明提供了抑制Akt活性的化合物。具体而言，所披露的化合物选择性地抑制一种或两种Akt同工酶。该发明还提供了包含这些抑制性化合物的组合物以及通过向需要癌症治疗的患者施用该化合物来抑制Akt活性的方法。
• Enzyme-cleavable prodrug compounds
  申请人：——

  公开号：US20020142955A1

  公开（公告）日：2002-10-03

  The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.

  本发明的前药是治疗剂的改良形式，包括治疗剂、寡肽、稳定基团和可选的连接基团。该前药可被Thimet寡肽酶或TOP酶水解。本发明还揭示了通过利用共轭物中可被TOP酶水解的序列设计前药的方法以及使用本发明的前药治疗患者的方法。
• Method and device for collecting and preserving cells for analysis
  申请人：Streck Laboratories, Inc.

  公开号：EP1413874A1

  公开（公告）日：2004-04-28

  The claimed subject matter comprises a device to collect and preserve cells comprising of: (1) a collection container comprised of a tube having an open end and a closed end, a closure in the open end of the tube, a vacuum drawn to a predetermined level inside the container; and (2) compounds including an anticoagulant agent and a fixative agent, wherein the compounds are in a sufficient amount to preserve said cells' original morphology and antigenic sites without significant dilution of said cells, and thereby allowing said cells to be directly analyzed by a flow cytometer without further treatment. The claimed subject matter further comprises of a method of making a collection device for cells comprising of : (1) providing a tube having an open end and a closed end; (2) preloading compounds including: an anticoagulant agent, and a fixative agent into the tube, wherein the compounds are in a sufficient amount to preserve the cells' original morphology and antigenic sites without significant dilution of the cells, and thereby allowing the cells to be directly analyzed by a flow cytometer without further treatment; (3) inserting a closure into the open end of the tube; and (4) drawing a vacuum inside the tube to a predetermined level to form the collection device.

  所述主题包括一种收集和保存细胞的装置，包括：(1)收集容器，由具有开口端和闭口端的管子、管子开口端的封口、容器内抽到预定水平的真空组成；以及(2)包括抗凝剂和固定剂的化合物，其中化合物的量足以保存所述细胞的原始形态和抗原位点，而不会显著稀释所述细胞，从而使所述细胞无需进一步处理即可直接用流式细胞仪分析。所述主题还包括一种细胞收集装置的制作方法，该方法包括：(1) 提供一个具有开口端和闭口端的管子；(2) 预装化合物，包括抗凝血剂、抗凝血剂、抗凝血剂、抗凝血剂、抗凝血剂、抗凝血剂、抗凝血剂、抗凝血剂和抗凝血剂：抗凝剂和固定剂，其中化合物的量足以保持细胞的原始形态和抗原位点，而不会显著稀释细胞，从而使细胞无需进一步处理即可直接用流式细胞仪分析；(3) 将封口插入管的开口端；(4) 将管内的真空度抽至预定水平，以形成收集装置。