1-(4-氟苯基)-N-甲基环己胺 | 78987-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-氟苯基)-N-甲基环己胺
• 英文名称: 1-(p-Fluorophenyl)-N-methylcyclohexylamine
• 英文别名: 1-(4-fluorophenyl)-N-methylcyclohexan-1-amine
• CAS: 78987-76-5
• 化学式: C₁₃H₁₈FN
• 分子量: 207.29
• InChiKey: UGURUEVWEYBRSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors
  申请人：Allen George David

  公开号：US20070111995A1

  公开（公告）日：2007-05-17

  The invention provides pyrazolo[3,4-b]pyridine compounds of formula (I) having a —C(O)—NH—C(R 4 )(R 5 )-aryl substituent at the 5-position of the pyrazolo[3,4-b]pyridine ring system wherein at least one of R 4 and R 5 is not a hydrogen atom (H) compound or a salt thereof: wherein Ar has the sub-formula (x) or (z). These compounds are useful as inhibitors of PDE4.

  本发明提供了式(I)的吡唑并[3,4-b]吡啶化合物，其在吡唑并[3,4-b]吡啶环系的5位具有—C(O)—NH—C(R4)(R5)-芳基取代基，其中R4和R5中至少有一个不是氢原子（H）化合物或其盐：其中Ar具有亚式（x）或（z）。这些化合物可用作PDE4的抑制剂。
• [EN] PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] COMPOSES PYRAZOLO [3,4-B] PYRIDINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PHOSPHODIESTERASE
  申请人：GLAXO GROUP LTD

  公开号：WO2005058892A1

  公开（公告）日：2005-06-30

  The invention provides a compound of formula (I) or a salt thereof, wherein Ar has the sub-formula (x) or (z) and wherein R3 is optionally substituted C3-8cycloalkyl, optionally substituted C5-7 cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc), or a bicyclic group (ee); and wherein R4 is H, C1-3 alkyl, C1-2fluoroalkyl, cyclopropyl, CH2OR4a, CH(Me)OR4a, or CH2CH2OR4a; and R5 is inter alia H, C1-8alkyl, C1-8fluoroalkyl, C3-8 cycloalkyl, certain substituted alkyl groups, -(CH2)n13- Het, or optionally substituted phenyl or CH2-Ph; or R4 and R5 taken together are -(CH2)p1- or (CH2)p3 X5 (CH2)p4- ; provided that at least one of R4 and R5 is not a hydrogen atom (H). The invention also provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, allergic rhinitis or atopic dermatitis.
• [EN] CANNABINOID RECEPTOR LIGANDS AND USES THEREOF<br/>[FR] LIGANDS DES RECEPTEURS DE CANNABINOIDE ET UTILISATIONS DE CEUX-CI
  申请人：PHARMACIA & UPJOHN CO LLC

  公开号：WO2007020502A2

  公开（公告）日：2007-02-22

  [EN] Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.
  [FR] La présente invention concerne des composés représentés par la formule (I) qui agissent comme des ligands des récepteurs de cannabinoïde et leurs utilisations dans le traitement de maladies liées à la médiation des récepteurs de cannabinoïde chez l'animal.