1-(4-氨基丁基)吡咯烷-2-酮 | 53653-64-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(4-氨基丁基)吡咯烷-2-酮
• 英文名称: 1-(4-Amino-butyl)-pyrrolidin-2-one
• 英文别名: 2-Pyrrolidinone, 1-(4-aminobutyl)-；1-(4-aminobutyl)pyrrolidin-2-one
• CAS: 53653-64-8
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: NJMVKNDAEBCSSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-氨基丁基)吡咯烷-2-酮 、 4-甲氧基苄胺 、 4,6-dichloro-[1,3,5]triazin-2-yl-4-methoxy-benzyl-amine 生成 1-{4-[4,6-Bis-(4-methoxy-benzylamino)-[1,3,5]triazin-2-ylamino]-butyl}-pyrrolidin-2-one
  参考文献：
  名称：

  A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening

  摘要：

  The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

  DOI：

  10.1021/ja026720i

文献信息

• Compounds that are Analogs of Squalamine, Used as Antibacterial Agents
  申请人：VIRBAC

  公开号：US20180042942A1

  公开（公告）日：2018-02-15

  The invention relates to compounds of formula (I), to the pharmaceutical compositions comprising same, and to the use thereof in the treatment of bacterial, fungal, viral and parasitic infections or in the treatment of cancer in humans or animals. In formula (I), R1 and R2 are as defined in claim 1.

  这项发明涉及公式（I）的化合物，包括相同的药物组成，以及在人类或动物中用于治疗细菌、真菌、病毒和寄生虫感染或治疗癌症的用途。在公式（I）中，R1和R2如权利要求1中定义的那样。
• OPTICAL RECORDING MEDIUM AND COMPOUND USED FOR THE SAME
  申请人：SHIOZAKI Hiroyoshi

  公开号：US20090306376A1

  公开（公告）日：2009-12-10

  A compound comprising a ring structure including a ring composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded to the ring structure.

  一种化合物，包括一个环结构，其中包括由四个碳原子和两个氮原子组成的环，以及与环结构相结合的取代或未取代的氨基团。
• Electron beam sensitive resist
  申请人：GAF CORPORATION

  公开号：EP0088977A2

  公开（公告）日：1983-09-21

  This invention describes an ionizing radiation sensitive material having high contrast, high sensitivity and comprised of a mixed half-ester or half amide of the reaction of an N-hydroxy or N-aminoalkyl amide and a hydroxy alkyl terminally unsaturated compound with an alkylvinyl ether-maleic anhydride copolymer. A typical material is made by reacting hydroxyethyl pyrrolidone and hydroxyethyl acrylate with octadecylvinyl ether-maleic anhydride copolymer.

  本发明描述了一种具有高对比度、高灵敏度的电离辐射敏感材料，由 N-羟基或 N-氨基烷基酰胺和羟基烷基末端不饱和化合物与烷基乙烯基醚-马来酸酐共聚物反应生成的混合半酯或半酰胺组成。 一种典型的材料是由羟乙基吡咯烷酮和丙烯酸羟乙酯与十八烷基乙烯基醚-马来酸酐共聚物反应制成的。
• Electron beam sensitive mixture resist
  申请人：GAF CORPORATION

  公开号：EP0126652A1

  公开（公告）日：1984-11-28

  This invention describes an improved ionizing radiation sensitive material having high contrast, high sensitivity and comprised of a metal complex of a mixed half-ester or half-amide product of the reaction of an N-hydroxy or N-aminoalkyl amide and a hydroxy alkyl terminally unsaturated compound with an alkylvinyl ether-maleic anhydride copolymer. A typical material is made by reacting a metal salt with the mixed half-ester or half-amide product of the reaction of an N-hydroxy or N-amino alkyl amide and a hydroxy alkyl terminally unsaturated compound with an alkyl vinyl ether-maleic anhydride copolymer.

  本发明描述了一种改进的电离辐射敏感材料，它具有高对比度、高灵敏度，由 N-羟基或 N-氨基烷基酰胺和羟基烷基末端不饱和化合物与烷基乙烯基醚-马来酸酐共聚物反应的混合半酯或半酰胺产物的金属络合物组成。 一种典型的材料是将金属盐与 N-羟基或 N-氨基烷基酰胺和羟基烷基末端不饱和化合物与烷基乙烯基醚-马来酸酐共聚物反应的混合半酯或半酰胺产物反应制成。
• OPTICAL RECORDING MEDIUM AND COMPOUND USED IN THE OPTICAL RECORDING MEDIUM
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1672626A1

  公开（公告）日：2006-06-21

  There are provided an optical recording medium which enables recording and playback with high quality using laser of 300 nm to 900 nm and a novel compound. An optical recording medium wherein the percentage change (|[a2 - a1]/a1| × 100) of the recording layer thickness (a2) at the recorded site of recording layer (A) after recorded with laser light compared with the recording layer thickness (a1) at unrecorded site of said recording layer (A) is less than 25% and the amount of change (|a2 - a1|) of the recording layer thickness (a2) at recorded site of said recording layer (A) after recorded with laser light compared with the recording layer thickness (a1) at unrecorded site of said recording layer (A) is controlled to be less than 15 nm. A compound comprising a six-membered ring structure composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded.

  本发明提供了一种光学记录介质，利用波长为 300 纳米至 900 纳米的激光和一种新型化合物可实现高质量的记录和重放。 一种光学记录介质，其中用激光记录后，记录层（A）的记录部位的记录层厚度（a2）与未记录部位的记录层厚度（a1）相比的变化百分比（|[a2-a1]/a1| ×100）小于 25%，且所述记录层（A）的记录部位的记录层厚度（a2）与未记录部位的记录层厚度（a1）相比的变化量（|a2-a1|）小于 25%。a1|）的变化量控制在 15 nm 以下。 一种由四个碳原子和两个氮原子以及一个取代或未取代的氨基键合而成的六元环结构的化合物。