1-(4-氨基苯基)乙烯醇 | 744978-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-氨基苯基)乙烯醇
• 英文名称: 1-(4-Aminophenyl)ethen-1-ol
• 英文别名: 1-(4-aminophenyl)ethenol
• CAS: 744978-39-0
• 化学式: C₈H₉NO
• 分子量: 135.16
• InChiKey: XWDWIXXXXVHYPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] NAMPT MODULATORS<br/>[FR] MODULATEURS DE NAMPT
  申请人：CYTOKINETICS INC

  公开号：WO2021159015A1

  公开（公告）日：2021-08-12

  Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

  提供了公式（II）的化合物或其药用可接受盐，其中R1、R2、R3、R4、R5、R6和p如本文所定义。还提供了包含公式（II）化合物或其药用可接受盐的药用可接受组合物。还提供了使用公式（II）化合物或其药用可接受盐的方法。
• Isomeric reagent tags for differential mobility spectrometry
  申请人：DH Technologies Development Pte. Ltd.

  公开号：US11085925B2

  公开（公告）日：2021-08-10

  Methods and systems for separating and/or quantifying compounds, using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can provide for the quantification of one or more compounds, for example, using isomeric labels that can be less costly to produce relative to conventional tags that incorporate stable-isotope labels. The present teachings can quantify the relative amount of a compound based on the effect of using an easily charged functional group as well as a functional group positioned at a resonant or non-resonant position through a DMS. In some aspects, methods and systems in accordance with various aspects of the present teachings provide for the detection and/or quantification of the analytes labeled with isomeric tags that can be differentiated via a DMS upstream of a first stage mass analyzer and/or prior to fragmentation of the labeled analyte, for example.

  本文提供了使用差示迁移率光谱法（DMS）分离和/或定量化合物的方法和系统。根据申请人教导的各个方面，这些方法和系统可以对一种或多种化合物进行定量，例如，使用异构体标签，相对于使用稳定同位素标签的传统标签，这种标签的生产成本较低。本教导可根据使用易带电官能团以及通过 DMS 定位在共振或非共振位置的官能团的效果来量化化合物的相对量。在某些方面，根据本教导各方面的方法和系统可检测和/或量化用异构体标签标记的分析物，这些异构体标签可通过第一级质量分析仪上游的DMS进行区分和/或在标记的分析物碎裂之前进行区分。
• METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1332133B1

  公开（公告）日：2008-07-09