1-(4-溴-2,5-二甲氧基苄基)哌嗪 | 1094424-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-溴-2,5-二甲氧基苄基)哌嗪
• 英文名称: 1-(4-Bromo-2,5-dimethoxybenzyl)piperazine
• 英文别名: 1-[(4-bromo-2,5-dimethoxyphenyl)methyl]piperazine
• CAS: 1094424-37-9
• 化学式: C₁₃H₁₉BrN₂O₂
• mdl: MFCD11204957
• 分子量: 315.21
• InChiKey: OHXVYXBOJDDYJS-UHFFFAOYSA-N

物化性质

• 沸点：
  391.7±37.0 °C(Predicted)
• 密度：
  1.335±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于丙酮（少许）、氯仿（少许）、

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NMN AND DERIVATIVES FOR ITS USE IN THE TREATMENT OF DEPRESSION AND/OR ANXIETY IN PATIENTS HAVING A FORM OF PARKINSONISM
  申请人：Nuvamid SA

  公开号：EP4079311A1

  公开（公告）日：2022-10-26

  The invention relates to compounds of formula (I) and/or of formula (Ia) for the prevention and/or treatment of depression and/or anxiety related to a Parkinsonism such as an alpha-synucleinopathy as well as compositions and kit of parts comprising the same.

  本发明涉及用于预防和/或治疗与帕金森病（如α-突触核蛋白病）相关的抑郁和/或焦虑症的式(I)和/或式(Ia)化合物，以及包含这些化合物的组合物和试剂盒。
• Treatment of dermatological conditions via neuromodulation
  申请人：Palo Alto Investors

  公开号：US11383084B2

  公开（公告）日：2022-07-12

  Methods for treating a subject for a dermatological condition are provided. Aspects of the invention include administering an effective amount of a neuromodulatory agent to a subject to treat the subject for the dermatological condition. Also provided are compositions, kits and systems for practicing the subject methods.

  本发明提供了治疗受试者皮肤病的方法。本发明的各个方面包括向受试者施用有效量的神经调节剂，以治疗受试者的皮肤病。本发明还提供了用于实施上述方法的组合物、试剂盒和系统。
• TARR receptor agonists for sexual dysfunction
  申请人：ReJoy

  公开号：US11337937B2

  公开（公告）日：2022-05-24

  The present invention discloses compositions, methods, and systems of treating female sexual dysfunction by stimulating the contraction of the smooth muscle of the nipple. The smooth muscle in the nipple expresses trace amine associated receptors and thus can be contracted through a class of trace amine associated receptor agonists such as octopamine or tyramine, but any agent that promotes contraction of smooth muscle can be considered for the methods and compositions described herein. The contraction of the smooth muscle erects the nipple and increases female sexual arousal. The smooth muscle stimulatory compound can be formulated in a solution, foam, ointment, gel, spray, lotion, powder, topical cream, emulsion, slow release capsule or any similar method, compound, or delivery vehicle including a pre-wetted gauze or cotton pad. Additionally, the disclosed composition can be used to improve the quality of a sexual experience, e.g., it can increase orgasm intensity or a subject's interest in sex, of females that do not suffer from sexual dysfunction.

  本发明公开了通过刺激乳头平滑肌收缩来治疗女性性功能障碍的组合物、方法和系统。乳头平滑肌表达痕量胺相关受体，因此可通过一类痕量胺相关受体激动剂（如章胺或酪胺）收缩，但本文所述的方法和组合物可考虑使用任何促进平滑肌收缩的制剂。平滑肌的收缩可使乳头勃起，增加女性的性兴奋。平滑肌刺激化合物可以配制成溶液、泡沫、软膏、凝胶、喷雾、乳液、粉末、外用乳霜、乳剂、缓释胶囊或任何类似的方法、化合物或输送载体，包括预先浸湿的纱布或棉垫。此外，所公开的组合物还可用于改善性体验的质量，例如，它可以提高性高潮的强度，或提高没有性功能障碍的女性对性的兴趣。
• Treatment of Dermatological Conditions via Neuromodulation
  申请人：Palo Alto Investors

  公开号：US20180311499A1

  公开（公告）日：2018-11-01

  Methods for treating a subject for a dermatological condition are provided. Aspects of the invention include administering an effective amount of a neuromodulatory agent to a subject to treat the subject for the dermatological condition. Also provided are compositions, kits and systems for practicing the subject methods.
• TARR Receptor Agonists for Sexual Dysfunction
  申请人：ReJoy

  公开号：US20200060997A1

  公开（公告）日：2020-02-27

  The present invention discloses compositions, methods, and systems of treating female sexual dysfunction by stimulating the contraction of the smooth muscle of the nipple. The smooth muscle in the nipple expresses trace amine associated receptors and thus can be contracted through a class of trace amine associated receptor agonists such as octopamine or tyramine, but any agent that promotes contraction of smooth muscle can be considered for the methods and compositions described herein. The contraction of the smooth muscle erects the nipple and increases female sexual arousal. The smooth muscle stimulatory compound can be formulated in a solution, foam, ointment, gel, spray, lotion, powder, topical cream, emulsion, slow release capsule or any similar method, compound, or delivery vehicle including a pre-wetted gauze or cotton pad. Additionally, the disclosed composition can be used to improve the quality of a sexual experience, e.g., it can increase orgasm intensity or a subject's interest in sex, of females that do not suffer from sexual dysfunction.