1-(4-硝基苯基)-3-(丙-2-基氨基)丙-2-醇 | 73825-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-硝基苯基)-3-(丙-2-基氨基)丙-2-醇
• 英文名称: 1-Isopropylamino-3-(p-nitrophenyl)-2-propanol
• 英文别名: 1-(4-nitrophenyl)-3-(propan-2-ylamino)propan-2-ol
• CAS: 73825-99-7
• 化学式: C12H18N2O3
• 分子量: 238.28
• InChiKey: XGAIEZLJSRQDHV-UHFFFAOYSA-N

物化性质

• 沸点：
  395.3±32.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• TARGETED DRUG RESCUE WITH NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF
  申请人：Exciva GmbH

  公开号：EP3618819A1

  公开（公告）日：2020-03-11
• [EN] TARGETED DRUG RESCUE WITH NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF<br/>[FR] TARGETED DRUG RESCUE AVEC DE NOUVELLES COMPOSITIONS, ASSOCIATIONS ET PROCÉDÉS CORRESPONDANTS
  申请人：EXCIVA UG HAFTUNGSBESCHRAENKT

  公开号：WO2018204713A1

  公开（公告）日：2018-11-08

  Compounds of Formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, metabolites thereof, derivatives thereof, prodrugs thereof, acid addition salts thereof, pharmaceutically acceptable salts thereof, or N-oxides thereof; or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of Formula I, or enantiomers thereof, metabolites thereof, derivatives thereof, prodrugs thereof, acid addition salts thereof, pharmaceutically acceptable salts thereof, or N-oxides thereof; or a combination thereof, wherein the compound is double and/or triple agent or ligand for CYP2D6, 5-HT2A, and/or 5HT2C receptors, and/or acetylcholinesterase are provided.