1-(5-甲基-2-噻吩基)-N-(2-吡啶基甲基)甲胺 | 892570-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(5-甲基-2-噻吩基)-N-(2-吡啶基甲基)甲胺
• 英文名称: 1-(5-methylthiophen-2-yl)-N-(pyridin-2-ylmethyl)methanamine
• 英文别名: N-[(5-methylthiophen-2-yl)methyl]-1-pyridin-2-ylmethanamine
• CAS: 892570-76-2
• 化学式: C₁₂H₁₄N₂S
• mdl: MFCD07395354
• 分子量: 218.323
• InChiKey: WBEAQJYXVNBGDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 1-(5-甲基-2-噻吩基)-N-(2-吡啶基甲基)甲胺 生成 C₄₈H₄₃N₄O₄PolS₂
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• US7595343B2
  申请人：——

  公开号：US7595343B2

  公开（公告）日：2009-09-29
• US9708305B2
  申请人：——

  公开号：US9708305B2

  公开（公告）日：2017-07-18
• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS DE L'HISTONE-DEACETYLASE
  申请人：METHYLGENE INC

  公开号：WO2003024448A2

  公开（公告）日：2003-03-27

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. (formula 1). All definitions are as the application.
• [EN] COMPOUNDS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES<br/>[FR] COMPOSÉS DE TRAITEMENT DE MALADIES HORMONODÉPENDANTES
  申请人：UNIV LAVAL

  公开号：WO2015024111A1

  公开（公告）日：2015-02-26

  Provided are compounds of general formula A and A', wherein X1 and X2 are each C, CH or N; R3 and R4 are each H, optionally substituted C1-C30 saturated or unsaturated chemical group, or together form an optionally substituted C5-C8 cycle; Z1; Z2 and Z3 are each N or CH; V is C=0, C=S or CH2; n is from 1 to 12; W1 and W2 are each H, CH2, O or S; and R1 and R2 are each H, Cr1C6 alkyl, C1C6 aryl, C1C12 alkylaryl, optionally substituted phenyl, C1C6 alkoxy, C1C6 thioalkoxy, F, CI, Br or I. These compounds inhibit steroid sulfatase (STS), act as selective estrogen receptor modulators (SERMs), increase alkaline phosphatase (ALP) activity, and are useful in the treatment of medical conditions involving hormones such as breast cancer, prostate cancer, endometriosis, osteoporosis, benign prostatic hyperplasia and endometrial cancer.