1-(6-氨基己基)-1H-吡咯-2,5-二酮2,2,2-三氟乙酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(6-氨基己基)-1H-吡咯-2,5-二酮2,2,2-三氟乙酸盐
• 英文名称: 6-(2,5-Dioxopyrrol-1-yl)hexylazanium;2,2,2-trifluoroacetate
• 英文别名: 6-(2,5-dioxopyrrol-1-yl)hexylazanium;2,2,2-trifluoroacetate
• 化学式: C12H17F3N2O4
• 分子量: 310.27
• InChiKey: RBQIUIPYPXTLRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.99
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF<br/>[FR] INHIBITEURS DE LA PROLIFÉRATION CELLULAIRE ET LEURS CONJUGUÉS
  申请人：NOVARTIS AG

  公开号：WO2014151030A1

  公开（公告）日：2014-09-25

  Disclosed herein are immunoconjugates comprising an inhibitor of Eg5 linked to an antigen binding moiety such as an antibody, useful for treating cell proliferative disorders. Also disclosed are novel inhibitors of Eg5 that can be used either alone or as part of an immunoconjugate to treat cell proliferation disorders. The Eg5 inhibitors include compounds of this formula as described herein: [insert last structure from page 68 here] The invention further provides pharmaceutical compositions comprising these compounds and immunoconjugates, optionally including a therapeutic co-agent, and methods to use these compounds, conjugates and compositions for treating cell proliferation disorders.

  本发明公开了包含Eg5抑制剂的免疫偶联物，该抑制剂与抗原结合部分如抗体相连，用于治疗细胞增殖紊乱。还公开了新颖的Eg5抑制剂，可以单独使用或作为免疫偶联物的一部分来治疗细胞增殖紊乱。Eg5抑制剂包括如本文所述的这种化合物的化合物：[在此插入第68页的最后一个结构]本发明进一步提供了包含这些化合物和免疫偶联物的药物组合物，可选地包括治疗共剂，以及使用这些化合物、偶联物和组合物来治疗细胞增殖紊乱的方法。
• [EN] HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONJUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS<br/>[FR] COLORANTS DE CYANINE THIOL-REACTIFS, HYDROPHILES ET PRODUITS CONJUGUES DE CEUX-CI AVEC DES BIOMOLECULES POUR PERMETTRE LE DIAGNOSTIC PAR FLUORESCENCE
  申请人：SCHERING AG

  公开号：WO2004065491A1

  公开（公告）日：2004-08-05

  This invention relates to new fluorescence dyes from the class of cyanine dyes, especially indotricarbocyanines with an absorption and fluorescence maximum in the spectral range of 700 to 900 nm, a thiol-specific reactive group, and three, preferably four, sulfonate groups, to an increase of water solubility as well as the production of dyes. This invention also relates to the conjugates of these dyes with biomolecules and uses thereof.

  本发明涉及一种新的荧光染料，属于青菁染料类，特别是吲哚三碳青菁染料，具有吸收和荧光最大值在700至900纳米波长范围内，具有硫醇特异性反应基团和三个，最好是四个，磺酸基团，以提高水溶性以及染料的生产。本发明还涉及这些染料与生物分子的结合物及其用途。
• Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
  申请人：——

  公开号：US20040260072A1

  公开（公告）日：2004-12-23

  This invention relates to new fluorescence dyes from the class of cyanine dyes, especially indotricarbocyanines with an absorption and fluorescence maximum in the spectral range of 700 to 900 nm, a thiol-specific reactive group, and three, preferably four, sulfonate groups, to an increase of water solubility as well as the production of dyes. This invention also relates to the conjugates of these dyes with biomolecules and uses thereof.

  本发明涉及一种新的荧光染料，属于青烯染料类，特别是吲哚三芳基青烯染料，其吸收和荧光最大值在700至900纳米的光谱范围内，具有巯基特异性反应基团和三个，优选四个磺酸基团，以提高水溶性以及染料的生产。本发明还涉及这些染料与生物分子的结合物及其用途。
• Use of cyanine dyes for the diagnosis of disease associated with angiogenesis
  申请人：Schirner Michael

  公开号：US20060039863A1

  公开（公告）日：2006-02-23

  This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, inflammatory lesions, e.g. psoriasis, psoriatic arthritis and/or rheumatoid arthritis, endometriotic lesions, and ocular diseases associated with angiogenesis.

  本发明涉及使用青霉素染料与血管生成特异性结合组分的共轭物，优选为EB-D纤维连接蛋白特异性结合组分，用于诊断微转移和小增殖病变，特别是原发肿瘤，癌前病变，畸形，化生，炎症病变，例如银屑病，银屑病性关节炎和/或类风湿性关节炎，子宫内膜异位症病变和与血管生成相关的眼部疾病。
• HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONJUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS
  申请人：Schering AG

  公开号：EP1585791A1

  公开（公告）日：2005-10-19