1-(三甲基甲硅烷基)-2,3-二(三甲基硅杂氧基)丙烷 | 154557-38-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 1-(三甲基甲硅烷基)-2,3-二(三甲基硅杂氧基)丙烷
• 中文别名: 1-(三甲基甲硅烷基)-2,3-双(三甲基甲硅烷基氧基)丙烷
• 英文名称: 2,3-bis(trimethylsilyloxy)-trimethylsilylpropane
• 英文别名: 2,2,7,7-tetramethyl-4-[(trimethylsilyl)methyl]-3,6-dioxa-2,7-disilaoctane；Trimethyl-(1-trimethylsilyl-3-trimethylsilyloxypropan-2-yl)oxysilane
• CAS: 154557-38-7
• 化学式: C₁₂H₃₂O₂Si₃
• 分子量: 292.641
• InChiKey: ZGNPKKBNNSGISB-UHFFFAOYSA-N

物化性质

• 沸点：
  182 °C(lit.)
• 密度：
  0.848 g/mL at 25 °C(lit.)
• 闪点：
  187 °F

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• WGK Germany：
  3

SDS

Version 1.3
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name 1-(TRIMETHYLSILYL)-2,3-BIS(TRIMETHYLSILY
L-OXY)PROPANE, 99%

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2 - Hazards Identification

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
1-(TRIMETHYLSILYL)-2,3-BIS(TRIMETH 154557-38-7 None None
YLSILYL-OXY)PROPANE, 99%
Formula C12H32O2Si3
Molecular Weight 292,6500 AMU

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4 - First Aid Measures

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AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

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5 - Fire Fighting Measures

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EXTINGUISHING MEDIA
Suitable: For small (incipient) fires, use media such as
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"alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large
quantities (flooding) of water applied as a mist or spray; solid
streams of water may be ineffective. Cool all affected
containers with flooding quantities of water.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

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6 - Accidental Release Measures

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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.

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7 - Handling and Storage

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HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.

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8 - Exposure Controls / Personal Protection

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ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Respiratory protection is not required. Where
protection is desired, use multi-purpose combination (US) or type
ABEK (EN 14387) respirator cartridges.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.

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9 - Physical and Chemical Properties

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Appearance Physical State: Liquid
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range 182,000 °C
MP/MP Range N/A
Flash Point 86,000 °C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0,8480 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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STABILITY
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Silicon oxide.

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11 - Toxicological Information

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SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  仲辛酮 、 1-(三甲基甲硅烷基)-2,3-二(三甲基硅杂氧基)丙烷 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以85%的产率得到(2-Hexyl-2-methyl-[1,3]dioxolan-4-ylmethyl)-trimethyl-silane
  参考文献：
  名称：

  The protection of ketones and aldehydes as 4-trimethylsilylmethyl-1,3-dioxolanes

  摘要：

  The 1,3-dioxolanation of carbonyl compounds with 2,3-bis(trimethylsilyloxy)-trimethylsilylpropane (BTTP) in the presence of catalytic amounts of trimethylsilyl trifluoromethanesulfonate (TMSOTf) has been investigated. BTTP readily converted unhindered ketones and aldehydes to their corresponding 4-trimethylsilylmethyl-19-dioxolanes, but failed for more hindered substrates. The 4-trimethylsilylmethyl-1,3-dioxolane can be selectively cleaved to regenerate the carbonyl compound in the presence of a 13-dioxolane using either LiBF4 or HF in acetonitrile.

  DOI：

  10.1016/s0040-4039(00)79941-2
• 作为产物：
  描述：

  三甲基氯硅烷 、 3-(三甲基硅基)-1,2-丙二醇 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到1-(三甲基甲硅烷基)-2,3-二(三甲基硅杂氧基)丙烷
  参考文献：
  名称：

  The protection of ketones and aldehydes as 4-trimethylsilylmethyl-1,3-dioxolanes

  摘要：

  The 1,3-dioxolanation of carbonyl compounds with 2,3-bis(trimethylsilyloxy)-trimethylsilylpropane (BTTP) in the presence of catalytic amounts of trimethylsilyl trifluoromethanesulfonate (TMSOTf) has been investigated. BTTP readily converted unhindered ketones and aldehydes to their corresponding 4-trimethylsilylmethyl-19-dioxolanes, but failed for more hindered substrates. The 4-trimethylsilylmethyl-1,3-dioxolane can be selectively cleaved to regenerate the carbonyl compound in the presence of a 13-dioxolane using either LiBF4 or HF in acetonitrile.

  DOI：

  10.1016/s0040-4039(00)79941-2

文献信息

• The protection of ketones and aldehydes as 4-trimethylsilylmethyl-1,3-dioxolanes
  作者：Brett M. Lillie、Mitchell A. Avery

  DOI：10.1016/s0040-4039(00)79941-2

  日期：1994.2

  The 1,3-dioxolanation of carbonyl compounds with 2,3-bis(trimethylsilyloxy)-trimethylsilylpropane (BTTP) in the presence of catalytic amounts of trimethylsilyl trifluoromethanesulfonate (TMSOTf) has been investigated. BTTP readily converted unhindered ketones and aldehydes to their corresponding 4-trimethylsilylmethyl-19-dioxolanes, but failed for more hindered substrates. The 4-trimethylsilylmethyl-1,3-dioxolane can be selectively cleaved to regenerate the carbonyl compound in the presence of a 13-dioxolane using either LiBF4 or HF in acetonitrile.