1-(甲基硫烷基)丙-2-胺 | 13296-25-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 1-(甲基硫烷基)丙-2-胺
• 英文名称: 1-methyl-2-(methylthio)ethylamine
• 英文别名: (S)-1-(methylthio)propan-2-amine；1-methylthio-2-propanamine；1-methylthio-2-propylamine；1-methyl-2-methylthioethylamine；1-(methylthio)-2-propanamine；1-Methylmercapto-propan-2-amin；1-(Methylsulfanyl)propan-2-amine；1-methylsulfanylpropan-2-amine
• CAS: 13296-25-8
• 化学式: C₄H₁₁NS
• mdl: MFCD13188154
• 分子量: 105.204
• InChiKey: ZXGNLASDUYGVFG-UHFFFAOYSA-N

物化性质

• 沸点：
  158.9±23.0 °C(Predicted)
• 密度：
  0.934±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-4-(2-chloro-4-pyridinyl)pyrimidine 、 1-(甲基硫烷基)丙-2-胺 以 甲苯 为溶剂， 反应 18.0h， 以88%的产率得到4-(2-chloro-4-pyridinyl)-N-[1-methyl-2-(methylthio)ethyl]-2-pyrimidinamine
  参考文献：
  名称：

  [EN] FUNGICIDAL HETEROCYCLIC AMINES
  [FR] AMINES FONGICIDES

  摘要：

  公开号：

  WO2009061761A3
• 作为产物：
  描述：

  1-methylsulfanyl-propan-2-one oxime 生成 1-(甲基硫烷基)丙-2-胺
  参考文献：
  名称：

  Free-Radical Cleavage of β-Hydroxy Thio Ethers to Ketones and Mercaptans¹

  摘要：

  DOI：

  10.1021/jo01348a059
• 作为试剂：
  描述：

  4-fluoro-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzonitrile 、 1-(甲基硫烷基)丙-2-胺 在 1-(甲基硫烷基)丙-2-胺 作用下， 生成 (R)-1-(1-(methylthio)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile
  参考文献：
  名称：

  [EN] INDOLECARBONITRILES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
  [FR] INDOLECARBONITRILES UTILISÉS COMME MODULATEURS SÉLECTIFS DES RÉCEPTEURS AUX ANDROGÈNES

  摘要：

  本发明涉及非甾体化合物，它们是雄激素受体的调节剂，以及制备和使用这种化合物的方法。

  公开号：

  WO2014013309A1

文献信息

• [EN] PROCESS FOR THE PREPARATION OF THIOALKYLAMINE DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES DE THIOALKYLAMINE
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2003099777A1

  公开（公告）日：2003-12-04

  The present invention relates to a novel process for the preparation of compounds of the formula (I) (I)by reacting in a first step amino alcohols of the formula (II) (II)with oleum to give sulphuric acid esters of the general formula (III) (III)and by reacting these sulphuric acid esters in a second step with mercaptans or salts thereof of the general formula (IV) (IV)in each formula, where applicable, R1, R2, R3, R4, R5, R6, R, n and M have the meanings given in the description,in the presence of a diluent and in the presence of a base.

  本发明涉及一种新型工艺，用于制备化合物的公式（I），通过在第一步中使公式（II）的氨基醇与油酸反应，得到一般公式（III）的硫酸酯，然后在第二步中使这些硫酸酯与一般公式（IV）的巯基或其盐反应，其中在每个公式中，如适用，R1、R2、R3、R4、R5、R6、R、n和M的含义如描述中所给，在稀释剂和碱的存在下。
• [EN] N1 - ((PYRAZOL-1-YMETHYL) -2-METHYLPHENYL)- PHATALAMIDE DERIVATIVES AND RELATED COMPOUNDS INSECTICIDES<br/>[FR] DERIVES DE N1 - ((PYRAZOL-1-YMETHYL) -2-METHYLPHENYL)- PHATALAMIDE ET COMPOSES INSECTICIDES ASSOCIES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2005095351A1

  公开（公告）日：2005-10-13

  Novel benzenedicarboxamides of the formula (I) wherein X represents hydrogen, halogen atom, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl, R1 represents C1-6alkyl, C1-6alkylthio-C1-6alkyl, C1-6alkylsulfinyl- C1-6alkyl or C1-6 alkylsulfonyl- C1-6alkyl, Y represents halogen or C1-6alkyl, m represents 0 or 1, A represents O, S, SO, SO2, CH2 or CH(CH3), and Q represents a 5- or 6-membered heterocyclic group that contains at least one hetero atom selected from the group consisting of N, O and S and can be optionally substituted; processes for their preparation, their intermediates and their use as insecticides.

  式（I）中的新型苯二甲酰胺，其中X代表氢、卤素原子、硝基、C1-6烷基磺酰氧基、C1-6烷基亚砜基、C1-6烷基硫基或C1-6烷基磺基，R1代表C1-6烷基、C1-6烷基硫基-C1-6烷基、C1-6烷基亚砜基-C1-6烷基或C1-6烷基磺酰基-C1-6烷基，Y代表卤素或C1-6烷基，m代表0或1，A代表O、S、SO、SO2、CH2或CH(CH3)，Q代表含有至少一种异原子（N、O和S）的5-或6元杂环基，并可选择性地取代；它们的制备方法、它们的中间体以及它们作为杀虫剂的用途。
• Process for production of thioalkylamine derivatives
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：US06639109B1

  公开（公告）日：2003-10-28

  The present invention relates to a thioalkylamine derivative represented by general formula (I); and a process for production thereof: wherein each of R1 and R2 is H, (C1-C4)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C4)alkyl, (substituted) phenyl, (substituted) phenyl(C1-C4)alkyl, or the like; each of R3 and R4 is H or a (C1-C4)alkyl group; each of R5 and R6 is H, (C1-C4)alkyl, a (substituted) phenyl group or a (substituted) phenyl(C1-C4)alkyl group; alternatively each of R1 and R2, R1 and R3 or R5, R3 and R4, R3 and R5 or R5 and R6 may together form lower alkylene; and R is (C1-C12)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C4)alkyl, (substituted) phenyl, (substituted) phenyl(C1-C4)alkyl, a naphthyl group, a (substituted) aromatic heterocyclic, or the like.

  本发明涉及一种由通式（I）表示的硫代烷胺衍生物；以及其生产工艺：其中R1和R2中的每一个是H，（C1-C4）烷基，（C3-C8）环烷基，（C3-C8）环烷基（C1-C4）烷基，（取代）苯基，（取代）苯基（C1-C4）烷基，或类似物；R3和R4中的每一个是H或（C1-C4）烷基；R5和R6中的每一个是H，（C1-C4）烷基，（取代）苯基或（取代）苯基（C1-C4）烷基；或者R1和R2，R1和R3或R5，R3和R4，R3和R5或R5和R6中的每一个组合形成较低的烷基；R为（C1-C12）烷基，（C3-C8）环烷基，（C3-C8）环烷基（C1-C4）烷基，（取代）苯基，（取代）苯基（C1-C4）烷基，萘基，（取代）芳香杂环基，或类似物。
• Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：US06603044B1

  公开（公告）日：2003-08-05

  The present invention provides a phthalamide derivative of the formula (I): wherein A1 is (substituted) C1-C8 alkylene, (substituted) C3-C8 alkenylene, (substituted) C3-C8 alkynylene, etc., R1 is H, (halo) C3-C6 cycloalkyl, (substituted) phenyl, (substituted) heterocycle, —A2—R4, etc., R2 and R3 are H, C3-C6 cycloalkyl, —A2—R4, etc., A2 is —C(═O)—, —C(═S)— or —C(═NR5)—, R4 is H, alkyl, (substituted) phenyl, (substituted) heterocycle, etc., X and Y are halogen, cyano, nitro, (halo) C1-C6 alkyl, (halo) C1-C6 alkoxy, etc., l is 0-4, m is 0-5, n is 0-2; and an agrohorticultural insecticide containing said compound as active ingredient and exhibiting an excellent insecticidal effect.

  本发明提供了公式（I）的邻苯二甲酰胺衍生物，其中A1是（取代的）C1-C8烷基，（取代的）C3-C8烯基，（取代的）C3-C8炔基等，R1是H，（卤代）C3-C6环烷基，（取代的）苯基，（取代的）杂环，-A2-R4等，R2和R3是H，C3-C6环烷基，-A2-R4等，A2是-C（═O）-，-C（═S）-或-C（═NR5）-，R4是H，烷基，（取代的）苯基，（取代的）杂环等，X和Y是卤素，氰基，硝基，（卤代）C1-C6烷基，（卤代）C1-C6烷氧基等，l为0-4，m为0-5，n为0-2；以及一种农业园艺杀虫剂，其含有该化合物作为活性成分，表现出优异的杀虫效果。
• Synthesis and fungicidal activity of 3,4-dichloroisothiazole based strobilurins as potent fungicide candidates
  作者：Lai Chen、Xiao-Feng Guo、Zhi-Jin Fan、Nai-Lou Zhang、Yu-Jie Zhu、Zhi-Ming Zhang、Inna Khazhieva、Morzherin Y. Yurievich、Nataliya P. Belskaya、Vasiliy A. Bakulev

  DOI：10.1039/c6ra25520e

  日期：——

  diffraction for validation. Results from different biological assays suggested that most target compounds displayed very good fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Among them, compounds 6d, 6g and 8d showed a broad spectrum of fungicidal activity. Further field experiments indicated that compound 8d displayed better efficacy against Sphaerotheca fuliginea than commercial

  设计并合成了一系列基于3,4-二氯异噻唑的新型strobilururin类似物，并通过NMR和HRMS阐明了它们的结构，并通过X射线衍射确定了典型的晶体结构以进行验证。从不同的生物测定结果表明，大部分目标化合物显示非常好的杀真菌活性对一种或多种植物病原体的体外和体内。其中，化合物6d，6g和8d显示出广谱的杀真菌活性。进一步的野外实验表明，化合物8d表现出更好的抗黄粉球菌功效比商业标准嘧菌酯和肟菌酯，以及对更好的疗效霜霉病比肟。总体而言，在这项研究中发现了一种新的植物病害防治杀真菌剂。