1-[2-(2,4-二氯苯基)-2-[[4-(三氟甲基)苯基]甲氧基]乙基]-1H-咪唑 | 1269726-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[2-(2,4-二氯苯基)-2-[[4-(三氟甲基)苯基]甲氧基]乙基]-1H-咪唑
• 英文名称: Dapaconazole
• 英文别名: 1-[2-(2,4-dichlorophenyl)-2-[[4-(trifluoromethyl)phenyl]methoxy]ethyl]imidazole
• CAS: 1269726-67-1
• 化学式: C₁₉H₁₅Cl₂F₃N₂O
• 分子量: 415.2
• InChiKey: FUAHXHWSMYFWGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(三氟甲基)苄基氯 生成 1-[2-(2,4-二氯苯基)-2-[[4-(三氟甲基)苯基]甲氧基]乙基]-1H-咪唑
  参考文献：
  名称：

  BENZYL ARALKYL ETHER COMPOUNDS, METHOD FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME

  摘要：

  该发明描述了一种新的抗真菌化合物，它们是公式（I）的芳基烷基苯醚，其中：Ar代表芳基，咪唑基，1,2,4-三唑基，苯并咪唑基；R1、R2、R4和R5独立地代表氢、卤素、C1-6烷基；R3代表卤素、C1-6烷基或O—R′，其中R′代表氢或较低的烷基；R6代表芳基、取代芳基、三氟甲基、三氯甲基或O—R′，其中R′代表氢或较低的烷基；芳基的取代基是卤素或四唑基基团；n和m分别表示介于0和5之间的整数；但是当Ar为咪唑基，R3为氯，R6为对苯基且R1、R2、R4和R5为氢时，n必须不等于2。当n和m不为0和1时，R3或R6可以用不必相等的取代基表示。该发明还涉及它们的盐、溶剂合物、前药、酯、对映体和/或药学上可接受的对映异构体或它们的混合物，制备这些化合物的过程，中间体化合物，包括这些化合物和/或衍生物的制药组合物，以及这些化合物和/或衍生物的用途和方法，用于治疗和/或预防由微生物引起的疾病和/或疾病，如真菌、细菌和/或原虫，用于抑制这些微生物的增殖和/或生存，用于治疗和/或预防微生物在个体中的定殖，并用于制药。

  公开号：

  US20120196908A1

文献信息

• [EN] SMALL MOLECULE STIMULATORS OF THE CORE PARTICLE OF THE PROTEASOME<br/>[FR] STIMULATEURS À PETITES MOLÉCULES DE LA PARTICULE DE NOYAU DU PROTÉASOME
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2021034627A1

  公开（公告）日：2021-02-25

  This present disclosure relates to series compounds and methods of use for the treatment of a disease caused by abnormal regulation of the ubiquitin-proteasome system (UPS), and wherein said compound is an effective stimulator of the 20S core particle (CP) of the UPS. Composition matters and methods of uses are within the scope of this disclosure.

  本公开涉及一系列化合物及其治疗由于泛素-蛋白酶体系统（UPS）异常调节引起的疾病的方法，其中所述化合物是UPS的20S核心粒子（CP）的有效刺激剂。本公开范围内涉及组成物和使用方法。
• [EN] BENZYL ARALKYL ETHER COMPOUNDS, METHOD FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME<br/>[FR] COMPOSÉS ÉTHERS ARALKYL BENZYLIQUES, PROCÉDÉ DE PRÉPARATION DE CEUX-CI, COMPOSÉS INTERMÉDIAIRES, UTILISATION DESDITS COMPOSÉS, MÉTHODE DE TRAITEMENT ET/OU DE PRÉVENTION, COMPOSITION PHARMACEUTIQUE ET MÉDICAMENT LES CONTENANT<br/>[PT] COMPOSTOS ÉTERES ARALQUIL BENZÍLICOS, PROCESSO DE PREPARAÇÃO DOS MESMOS, COMPOSTOS INTERMEDIÁRIOS, USO DOS REFERIDOS COMPOSTOS, MÉTODO DE TRATAMENTO E/OU PREVENÇÃO, COMPOSIÇÃO FARMACÊUTICA E MEDICAMENTO CONTENDO OS MESMOS
  申请人：BIOLAB SANUS FARMACEUTICA LTDA

  公开号：WO2011022798A1

  公开（公告）日：2011-03-03

  A presente invenção descreve novos compostos antifúngicos que são éteres aralquil benzílicos, da fórmula (I): onde: Ar representa aril, imidazolil, 1,2,4-triazolil, benzimidazolil; R1, R2, R4 e R5 representam, independentemente, hidrogênio, halogênio, C1-6 alquil; R3 representa halogênio, C1-6 alquil ou O-R', onde R' representa hidrogênio ou alquilas inferiores; R6 representa aril, aril substituído, trifluormetil, triclorometil ou O-R', onde R' representa hidrogênio ou alquilas inferiores, sendo os substituintes do aril um halogênio ou um radical tetrazolil; n e m representam, independentemente, um número inteiro compreendido entre 0 e 5; com a condição de que, quando Ar for imidazolil, R3 for cloro, R6 for p-fenila e R1, R2, R4 e R5 forem hidrogênios, n deve ser diferente de 2. Quando n e m for diferente de 0 e 1, R3 ou R6 podem ser representados por substituintes não necessariamente iguais A presente invenção também se refere aos seus sais, solvatos, pró-drogas, ésteres, enantiômeros e/ou diastereoisômeros farmaceuticamente aceitáveis, ou misturas dos mesmos, aos processos para a preparação dos referidos compostos, a compostos intermediários, a composições farmacêuticas compreendendo os referidos compostos e/ou derivados, aos medicamentos compreendendo os referidos compostos e/ou derivados, assim como aos usos e métodos dos referidos compostos e/ou derivados para o tratamento e/ou prevenção de condições e/ou doenças causadas por microorganismos, tais como, fungos, bactérias e/ou protozoários, para a inibição da proliferação e/ou sobrevivência dos ditos microorganismos, para tratamento e/ou prevenção de colonização de microrganismos em um indivíduo, e para a manufatura de um medicamento.

  本发明描述了新的抗真菌化合物，它们是芳基烷基苯甲醚，其化学式为（I）：其中：Ar代表芳基，咪唑基，1,2,4-三唑基，苯并咪唑基; R1、R2、R4和R5独立地代表氢、卤素、C1-6烷基; R3代表卤素、C1-6烷基或O-R'，其中R'代表氢或较低的烷基; R6代表芳基、取代芳基、三氟甲基、三氯甲基或O-R'，其中R'代表氢或较低的烷基，芳基的取代基是卤素或四唑基基团; n和m独立地代表0到5之间的整数；但当Ar为咪唑基，R3为氯，R6为对苯基且R1、R2、R4和R5为氢时，n必须不等于2。当n和m不等于0和1时，R3或R6可以用不一定相同的取代基表示。本发明还涉及其盐、溶剂化物、前药、酯、对映体和/或药理学上可接受的非对映体混合物，制备所述化合物的方法，中间体化合物，包含所述化合物和/或衍生物的药物组合物，包含所述化合物和/或衍生物的药物，以及所述化合物和/或衍生物用于治疗和/或预防由微生物引起的疾病和/或疾病的用途和方法，例如，真菌，细菌和/或原虫，抑制所述微生物的增殖和/或生存，治疗和/或预防微生物在个体内的定殖，以及制造药物。
• BENZYL ARALKYL ETHER COMPOUNDS, METHOD FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME
  申请人：Keppler Artur Franz

  公开号：US20120196908A1

  公开（公告）日：2012-08-02

  This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I): wherein: Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil; R 1 , R 2 , R 4 and R 5 are independently hydrogen, halogen, C 1-6 alkyl; R 3 represents halogen, C 1-6 alkyl or O—R′ where R′ represents hydrogen or lower alkyl; R 6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O—R′ where R′ represents hydrogen or lower alkyl; being the substituents of the aryl a halogen or a radical tetrazolyl; n and m represent independently an integer between 0 and 5; With the proviso that when Ar is imidazolil, R 3 is chlorine, R 6 is p-phenyl and R 1 , R 2 , R 4 and R 5 are hydrogen, n must be different from 2. When n and m are not 0 and 1, R 3 or R 6 can be represented by substituents not necessarily equal. This invention also refers to their salts, solvates, prodrugs, esters, enantiomers and/or pharmaceutically acceptable diastereoisomers, or mixtures thereof, processes for the preparation of these compounds, intermediate compounds, pharmaceutical compositions comprising such compounds and/or derivatives, including those compounds and/or derivatives, as well as the uses and methods of these compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by microorganisms such as fungi, bacteria and/or protozoa, for the inhibition of proliferation and/or survival of said microorganisms, for the treatment and/or prevention of colonization of microorganisms in an individual, and for the manufacture of a medicine.

  该发明描述了一种新的抗真菌化合物，它们是公式（I）的芳基烷基苯醚，其中：Ar代表芳基，咪唑基，1,2,4-三唑基，苯并咪唑基；R1、R2、R4和R5独立地代表氢、卤素、C1-6烷基；R3代表卤素、C1-6烷基或O—R′，其中R′代表氢或较低的烷基；R6代表芳基、取代芳基、三氟甲基、三氯甲基或O—R′，其中R′代表氢或较低的烷基；芳基的取代基是卤素或四唑基基团；n和m分别表示介于0和5之间的整数；但是当Ar为咪唑基，R3为氯，R6为对苯基且R1、R2、R4和R5为氢时，n必须不等于2。当n和m不为0和1时，R3或R6可以用不必相等的取代基表示。该发明还涉及它们的盐、溶剂合物、前药、酯、对映体和/或药学上可接受的对映异构体或它们的混合物，制备这些化合物的过程，中间体化合物，包括这些化合物和/或衍生物的制药组合物，以及这些化合物和/或衍生物的用途和方法，用于治疗和/或预防由微生物引起的疾病和/或疾病，如真菌、细菌和/或原虫，用于抑制这些微生物的增殖和/或生存，用于治疗和/或预防微生物在个体中的定殖，并用于制药。
• US8975289B2
  申请人：——

  公开号：US8975289B2

  公开（公告）日：2015-03-10