比马碘铵 | 21817-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 比马碘铵
• 中文别名: 必碘马苏
• 英文名称: Bidimazium iodide
• 英文别名: N,N-dimethyl-4-[(E)-2-[3-methyl-4-(4-phenylphenyl)-1,3-thiazol-3-ium-2-yl]ethenyl]aniline;iodide
• CAS: 21817-73-2
• 化学式: C26H25IN2S
• 分子量: 524.5
• InChiKey: MASAXPHKNKHIES-UHFFFAOYSA-M

物化性质

• 熔点：
  167 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Intraruminal drug delivery device
  申请人：COOPERS ANIMAL HEALTH LIMITED

  公开号：EP0333311A1

  公开（公告）日：1989-09-20

  An intraruminal device for administering an active agent in the rumen of an animal, comprises a metal weight (8) which gives the device sufficient density to be retained in the rumen which is made from compacted unsintered metal. The metal weight may be cylindrical and constructed of one (8, 20, 37 or 44) or several (31,32) pieces of compacted unsintered metal, of a tubular or annular (21,69) nature or incorporated as a discrete mass (66) within a drug matrix (67). When the weight is in an exposed position of the device (e.g. Fig.4), it is preferably enclosed with a material (38) that prevents damage to the weight from rough handling.

  一种用于在动物瘤胃中施用活性剂的瘤胃内装置，包括一个金属重块（8），它使装置具有足够的密度，可保留在瘤胃中，金属重块由压实的未烧结金属制成。金属砝码可以是圆柱形的，由一块（8、20、37 或 44）或几块（31、32）压实的未烧结金属组成，具有管状或环状（21、69）的性质，或作为一个离散的块状物（66）包含在药物基质（67）中。当砝码处于设备的外露位置时（如图 4），最好用材料（38）将其封闭，以防止砝码因粗暴操作而损坏。
• Dispensing devices
  申请人：COOPERS ANIMAL HEALTH LIMITED

  公开号：EP0398663A1

  公开（公告）日：1990-11-22

  An intraruminal device for administering an active agent into the rumen of an animal, comprising a chamber (3) enclosing the active material between a closure (2) and propulsion means (a piston) (8), one of the closure and propulsion means has one or more apertures for expulsion of the active material. The active material is conveniently expelled from the device by means of a piston biased against it by the tension of the spring. The tension spring may be constructed of materials that are environmentally preferred to metal springs and in addition hold the device together.

  一种将活性剂注入动物瘤胃的瘤胃内装置，包括一个腔室（3），将活性物质封闭在封闭装置（2）和推进装置（活塞）（8）之间，其中一个封闭装置和推进装置有一个或多个孔，用于排出活性物质。通过活塞在弹簧拉力的作用下将活性材料排出装置，非常方便。拉力弹簧可由比金属弹簧更环保的材料制成，此外还可将装置固定在一起。
• Release devices
  申请人：CASTEX PRODUCTS LIMITED

  公开号：EP0164927B1

  公开（公告）日：1988-10-26
• PHARMACEUTICAL PREPARATION COMPRISING AN ACTIVE DISPERSED ON A MATRIX
  申请人：ALTANA Pharma AG

  公开号：EP1341527A1

  公开（公告）日：2003-09-10