1-丙基-2-异丙基-肼 | 3711-28-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-丙基-2-异丙基-肼
• 英文名称: 1-Propyl-2-isopropyl-hydrazin
• 英文别名: 1-Isopropyl-2-propylhydrazin；1-Isopropyl-2-propylhydrazine；1-propan-2-yl-2-propylhydrazine
• CAS: 3711-28-2
• 化学式: C₆H₁₆N₂
• 分子量: 116.206
• InChiKey: PNBRACSSFLTMRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-丙基-2-异丙基-肼 在 mercury(II) oxide 作用下， 以 水 为溶剂， 生成 Propylazo-isopropan
  参考文献：
  名称：

  Synthesis of Unsymmetrical Azoalkanes from Acylalkylhydrazones and 1,2-Dialkylhydrazines¹

  摘要：

  DOI：

  10.1021/jo01021a004
• 作为产物：
  描述：

  propionic acid isopropylidenehydrazide 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 1-丙基-2-异丙基-肼
  参考文献：
  名称：

  Synthesis of Unsymmetrical Azoalkanes from Acylalkylhydrazones and 1,2-Dialkylhydrazines¹

  摘要：

  DOI：

  10.1021/jo01021a004

文献信息

• [EN] 9-(2-OXACYCLOALKYL)-9H-PURINE-2,6-DIAMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SKIN DISORDERS<br/>[FR] DÉRIVÉS DE 9-(2-OXACYCLOALKYL)-9H-PURINE-2,6-DIAMINE ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES CUTANÉS
  申请人：UNIV PALACKEHO

  公开号：WO2018196893A1

  公开（公告）日：2018-11-01

  The invention relates to N 2 ,N 6 -disubstituted-9-(2-oxacycloalkyl)-9H-purine-2,6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.

  该发明涉及N2，N6-二取代-9-(2-氧杂环烷基)-9H-嘌呤-2,6-二胺衍生物及其作为药物和化妆品的用途。本发明的化合物展现出与氧化应激抑制相关的多种生物活性，特别是抗衰老、抗炎和抗神经退行性生物活性。该发明还涉及含有这些衍生物作为活性剂的化妆品和药用组合物。
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：SPEEDEL EXPERIMENTA AG

  公开号：WO2009071606A1

  公开（公告）日：2009-06-11

  The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which in which R1 has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.

  本发明涉及一般式（I）的化合物及其盐，优选其药用可接受的盐；其中R1的含义如描述中所解释，以及它们的制备方法和将这些化合物用作药物，特别是作为肾素抑制剂。
• Substituted quinazolines as antiviral agents, especially against cytomegaloviruses
  申请人：Wunberg Tobias

  公开号：US20060235032A1

  公开（公告）日：2006-10-19

  The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

  本发明涉及取代的喹唑啉及其制备方法，以及在制备治疗和/或预防疾病的药物中的应用，特别是作为抗病毒剂，特别是针对巨细胞病毒的应用。
• NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：KIM Sun-Young

  公开号：US20080312234A1

  公开（公告）日：2008-12-18

  This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

  本发明涉及一种新型化合物、其异构体或其药学上可接受的盐作为vanilloid受体（Vanilloid Receptor 1；VR1；TRPV1）拮抗剂；以及包含该化合物的药物组合物。本发明提供了一种用于预防或治疗疾病的药物组合物，例如疼痛、偏头痛、关节痛、神经痛、神经病、神经损伤、皮肤疾病、膀胱过敏、肠易激综合症、排便紧迫、呼吸道疾病、皮肤、眼睛或粘膜刺激、胃十二指肠溃疡、炎症性疾病、耳疾病、心脏疾病等。
• ORGANIC COMPOUNDS
  申请人：Herold Peter

  公开号：US20100303926A1

  公开（公告）日：2010-12-02

  The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which in which R 1 has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.

  本发明涉及一般式（I）的化合物及其盐，优选为其药学上可接受的盐；其中R1的含义在说明中有解释，其制备过程以及这些化合物作为药物的用途，特别是作为肾素抑制剂。