1-二氟甲氧基-2-氟萘 | 878998-79-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-二氟甲氧基-2-氟萘
• 英文名称: 1-difluoromethoxy-2-fluoronaphthalene
• 英文别名: 1-(Difluoromethoxy)-2-fluoronaphthalene
• CAS: 878998-79-9
• 化学式: C₁₁H₇F₃O
• 分子量: 212.171
• InChiKey: WPGIGLBOTUBRCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-二氟甲氧基-2-氟萘 在 氢溴酸 、 溶剂黄146 作用下， 反应 14.0h， 以85%的产率得到2-氟-1-萘酚
  参考文献：
  名称：

  A new synthesis of 2-fluoro-1-naphthols

  摘要：

  A general synthesis of 2-fluoro-1-naphthols in two steps from 1-indanones is reported. The 1-indanones are first converted to difluoromethyl 2-fluoro-1-napthyl ethers by reaction with difluorocarbene source, trimethylsilyl 2-fluorosulfonyl-2,2-difluoroacetate (TFDA). These ethers are then converted in high yield to the respective naphthols by heating with a mixture of acetic acid and 48% HBr. (c) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2004.11.006
• 作为产物：
  描述：

  1-茚酮 、 三甲基硅烷基 2-(氟磺酰基)二氟乙酸酯 在 sodium fluoride 作用下， 以 xylene 为溶剂， 反应 3.0h， 以77%的产率得到1-二氟甲氧基-2-氟萘
  参考文献：
  名称：

  A new synthesis of 2-fluoro-1-naphthols

  摘要：

  A general synthesis of 2-fluoro-1-naphthols in two steps from 1-indanones is reported. The 1-indanones are first converted to difluoromethyl 2-fluoro-1-napthyl ethers by reaction with difluorocarbene source, trimethylsilyl 2-fluorosulfonyl-2,2-difluoroacetate (TFDA). These ethers are then converted in high yield to the respective naphthols by heating with a mixture of acetic acid and 48% HBr. (c) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2004.11.006

文献信息

• A new synthesis of 2-fluoro-1-naphthols
  作者：Xiaohong Cai、Kai Wu、William R. Dolbier

  DOI：10.1016/j.jfluchem.2004.11.006

  日期：2005.4

  A general synthesis of 2-fluoro-1-naphthols in two steps from 1-indanones is reported. The 1-indanones are first converted to difluoromethyl 2-fluoro-1-napthyl ethers by reaction with difluorocarbene source, trimethylsilyl 2-fluorosulfonyl-2,2-difluoroacetate (TFDA). These ethers are then converted in high yield to the respective naphthols by heating with a mixture of acetic acid and 48% HBr. (c) 2004 Elsevier B.V. All rights reserved.