1-异喹啉乙酸,1,2,3,4-四氢-,甲基酯,盐酸(1:1) | 88168-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 1-异喹啉乙酸,1,2,3,4-四氢-,甲基酯,盐酸(1:1)
• 英文名称: 5-(4-amino-phenyl)-5-phenyl-imidazolidine-2,4-dione
• 英文别名: 5-(4-Amino-phenyl)-5-phenyl-imidazolidin-2,4-dion；p-Aminophenytoin；5-(4-aminophenyl)-5-phenylimidazolidine-2,4-dione
• CAS: 88168-80-3
• 化学式: C₁₅H₁₃N₃O₂
• 分子量: 267.287
• InChiKey: NWQNTMVPBBAVCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• THERAPEUTIC INVENTION
  申请人：KAPOOR Raju

  公开号：US20130005786A1

  公开（公告）日：2013-01-03

  The invention provides a method of treating acute demyelinating optic neuritis in a patient suffering therefrom, which method comprises administering a compound to the patient, wherein the compound is phenytoin or an analog or prodrug thereof. The compound acts as a neuroprotectant by partial blocking of voltage-gated sodium channels in axonal other cell membranes thereby reducing the entry of sodium into the respective cell in vivo. The treatment is particularly concerned with preserving vision after onset of the acute demyelinating optic neuritis.
• US4006232A
  申请人：——

  公开号：US4006232A

  公开（公告）日：1977-02-01