1-氯-2-(2-氯-1,1-二甲氧基乙基)苯 | 1206904-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-氯-2-(2-氯-1,1-二甲氧基乙基)苯
• 英文名称: 1-chloro-2-(2-chloro-1,1-dimethoxyethyl)benzene
• 英文别名: 1-Chloro-2-(2-chloro-1,1-dimethoxyethyl)benzene
• CAS: 1206904-22-4
• 化学式: C₁₀H₁₂Cl₂O₂
• 分子量: 235.11
• InChiKey: PXITUXYJFQBXIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 2-氯苯甲醛 在 哌啶 、 1,3-二氯-5,5-二甲基海因 作用下， 反应 12.0h， 以85%的产率得到1-氯-2-(2-氯-1,1-二甲氧基乙基)苯
  参考文献：
  名称：

  One-Step Conversion of Acetophenones to α-Haloacetophenone Dimethyl Acetals Using DCDMH/DBDMH and Molecular Sieve in Methanol

  摘要：

  Using DCDMH/DBDMH as N-halo reagent, piperidine as catalyst, and 4-A molecular sieve as water-removing agent, alpha-haloacetophenone dimethyl acetals were directly obtained from the solvent of methanol. As to the substrates with electron-withdrawing groups, the conversions were 80-100%.

  DOI：

  10.1080/00397911.2010.540696

文献信息

• Mild and Efficient α-Chlorination of Carbonyl Compounds Using Ammonium Chloride and Oxone (2KHSO₅·KHSO₄·K₂SO₄)
  作者：Peraka Swamy、Macharla Arun Kumar、Marri Mahender Reddy、Nama Narender

  DOI：10.1246/cl.2012.432

  日期：2012.4.5

  A simple protocol for the α-monochlorination of ketones and 1,3-dicarbonyl compounds utilizing NH4Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.

  提出了一种简单的酮和1,3-二羰基化合物的α-单氯化反应方案，使用NH4Cl作为氯源，Oxone作为氧化剂，在无催化剂的甲醇中进行。反应在室温下进行，产率从中等至优异不等。
• One-Step Conversion of Acetophenones to <font>α</font>-Haloacetophenone Dimethyl Acetals Using DCDMH/DBDMH and Molecular Sieve in Methanol
  作者：Bin Zhou、Zizhan Chen、Zubiao Zheng、Bingbing Han、Xinzhuo Zou

  DOI：10.1080/00397911.2010.540696

  日期：2012.5.15

  Using DCDMH/DBDMH as N-halo reagent, piperidine as catalyst, and 4-A molecular sieve as water-removing agent, alpha-haloacetophenone dimethyl acetals were directly obtained from the solvent of methanol. As to the substrates with electron-withdrawing groups, the conversions were 80-100%.