1-氰基-4-二甲基氨基吡啶鎓 | 59016-55-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-氰基-4-二甲基氨基吡啶鎓
• 英文名称: 1-Cyano-4-dimethylaminopyridinium
• 英文别名: 4-(dimethylamino)pyridin-1-ium-1-carbonitrile
• CAS: 59016-55-6
• 化学式: C8H10N3+
• 分子量: 148.19
• InChiKey: AIHDUTVBOYDXOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel G protein-coupled receptor protein, its DNA and ligand thereof
  申请人：——

  公开号：US20040132073A1

  公开（公告）日：2004-07-08

  The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

  本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗各种疾病的药物，如与催乳素分泌相关的促催乳素分泌剂，如卵巢功能减退症、精子发育不全、更年期症状、甲状腺功能减退症等。这些多肽可用作预防和治疗各种疾病的药物，如与催乳素分泌相关的抑制催乳素分泌剂，如垂体瘤、间脑瘤、月经紊乱、自身免疫疾病、催乳素瘤、不育、阳痿、闭经、乳汁分泌、肢端肥大症、Chiari-Frommel综合征、Argonz-del Castilo综合征、Forbes-Albright综合征、淋巴瘤、希汉氏综合征、精子发生障碍等。
• OXONIUM AND SULFONIUM SALTS
  申请人：Ignatyev Nikolai (Mykola)

  公开号：US20090036628A1

  公开（公告）日：2009-02-05

  The present invention relates to oxonium salts having [(R o ) 3 O] + cations and sulfonium salts having [(R o ) 3 S] + cations, where R o denotes straight-chain or branched alkyl groups having 1-8 C atoms or phenyl which is unsubstituted or substituted by R o , OR o , N(R o ) 2 , CN or halogen, and anions selected from the group of [PF x (C y F 2y+1−z H z ) 6−x ] − anions, where 2≦x≦5, 1≦y≦8 and 0≦z≦2y+1, or anions selected from the group of [BF n (CN) 4−n ] − anions, where n=0, 1 , 2 or 3, or anions selected from the group of [(R f1 SO 2 ) 2 N] − anions or anions selected from the group of [BF w R f2 4−w ] − anions, to processes for the preparation thereof, and to the use thereof, in particular for the preparation of ionic liquids.

  本发明涉及具有[(Ro)3O]+阳离子和[(Ro)3S]+阳离子的氧化铵盐和磺化铵盐，其中Ro表示直链或支链烷基基团，含有1-8个碳原子，或者未被Ro，ORo，N(Ro)2，CN或卤素取代的苯基，并且阴离子选自[PFx(CyF2y+1−zHz)6−x]−阴离子组，其中2≦x≦5，1≦y≦8，0≦z≦2y+1，或者选自[BFn(CN)4−n]−阴离子组，其中n=0, 1, 2或3，或者选自[(Rf1SO2)2N]−阴离子组或选自[BFwRf24−w]−阴离子组，以及其制备方法和用途，特别是用于制备离子液体。
• [EN] IMMUNOGENIC COMPOSITIONS AGAINST S. AUREUS<br/>[FR] COMPOSITIONS IMMUNOGÈNES CONTRE S. AUREUS
  申请人：SANOFI PASTEUR

  公开号：WO2017064190A1

  公开（公告）日：2017-04-20

  The invention relates to a conjugate of a saccharide covalently bound to a carrier protein, wherein the saccharide comprises repetitive units of 1,5 ribitol phosphate in which all the ribitol residues are substituted by N-acetyl D-glucosaminyl residues at the 4-position, and wherein said N-acetyl D-glucosaminyl residues are exclusively in anomeric configuration α or are exclusively in anomeric configuration β and wherein the carrier protein provides at least one epitope to the conjugate which is recognized by T helper lymphocytes.

  该发明涉及一种被共价结合到载体蛋白质的糖苷共轭物，其中该糖苷包括1,5核糖醇磷酸的重复单元，在这些核糖醇残基的4位被N-乙酰-D-葡萄糖胺残基取代，并且所述的N-乙酰-D-葡萄糖胺残基仅以α异构或仅以β异构的构型存在，载体蛋白质为该共轭物提供至少一个被T辅助淋巴细胞识别的表位。
• Polypeptides, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US20030092618A1

  公开（公告）日：2003-05-15

  This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.

  本发明涉及一种新型多肽，涉及中枢神经系统功能、循环功能、免疫功能、胃肠功能、代谢功能、生殖功能等的调节，它可以用作治疗或预防各种疾病的药物，例如HIV感染或艾滋病（获得性免疫缺陷综合症）等。
• PROCESS FOR THE PREPARATION OF ONIUM SALTS WITH ALKYL- OR ARYLSULFONATE ANIONS OR ALKYL- OR ARYLCARBOXYLATE ANIONS HAVING A LOW HALIDE CONTENT
  申请人：Ignatyev Nikolai (Mykola)

  公开号：US20090253905A1

  公开（公告）日：2009-10-08

  The invention relates to a method for producing onium salts comprising alkyl anions or aryl sulfonate anions or alkyl carboxylate anions or acryl carboxylate anions by reacting an onium halide with an alkyl silyl ester or trialkyl silyl ester of an alkyl sulfonic acid or aryl sulfonic acid or an alkyl carboxylic acid or aryl carboxylic acid or the anhydrides thereof.

  本发明涉及一种生产含有烷基阴离子或芳基磺酸盐阴离子或烷基羧酸盐阴离子或丙烯酸盐阴离子的离子盐的方法，其通过将离子卤化物与烷基硅酯或烷基磺酸或芳基磺酸的三烷基硅酯或烷基羧酸或芳基羧酸或其酐进行反应而得到。