4-(2,5-dioxopyrrol-1-yl)-N-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]butanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-(2,5-dioxopyrrol-1-yl)-N-[2-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]butanamide
• 化学式: C₂₉H₃₉N₇O₈
• 分子量: 613.7
• InChiKey: QWFUFICOPBKRNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  44
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  184
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• CHEMICAL STRUCTURES FOR LOCALIZED DELIVERY OF THERAPEUTIC AGENTS
  申请人：The Regents of the University of California

  公开号：US20160120987A1

  公开（公告）日：2016-05-05

  The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

  本发明提供了一种方法，通过植入与第一结合剂相连的生物相容性固体支持物在患者体内，以及向患者注射与治疗或诊断剂相连的第二结合剂，从而将治疗或诊断剂有选择地传递到目标器官或组织，使治疗或诊断剂在目标器官或组织积累。
• Chemical structures for localized delivery of therapeutic agents
  申请人：The Regents of the University of California

  公开号：US10953098B2

  公开（公告）日：2021-03-23

  The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

  本发明提供了一种向目标器官或组织选择性递送治疗剂或诊断剂的方法，即在患者体内植入与第一结合剂相连的生物相容性固体支撑物，并向患者施用与治疗剂或诊断剂相连的第二结合剂，从而使治疗剂或诊断剂在目标器官或组织聚集。