氧氯丙嗪 | 316-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 氧氯丙嗪
• 英文名称: chlorpromazine sulfoxide hydrochloride
• 英文别名: chlorpromazine-5-oxide hydrochloride；Opromazine hydrochloride；3-(2-chloro-5-oxophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
• CAS: 316-07-4
• 化学式: C₁₇H₁₉ClN₂OS*ClH
• 分子量: 371.331
• InChiKey: VWLMLCOTJLYYST-UHFFFAOYSA-N

物化性质

• 熔点：
  204-205 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  盐酸氯丙嗪 在 双氧水 作用下， 以 乙醇 为溶剂， 以95.5%的产率得到氧氯丙嗪
  参考文献：
  名称：

  Synthesis and Molecular Structure of Zwitterionic Complexes of Phenothiazine-5-oxide Derivatives Coordinated with Cobalt(II) and Copper(II) Ions.

  摘要：

  本文描述了 Co(II)CI2 和 Cu(II)Cl2 与 2-氯-10-(3-二甲基氨基丙基)吩噻嗪-5-氧化物盐酸盐（cpz(O)HCl）及三种相关化合物配合物的合成和表征。通过单晶 X 射线衍射分析，确定了 [CoCl3cpz(O)H] (1) 和 [CuCl3 cpz(O)H] (2) 复合物的晶体结构。1 结晶于单斜空间群 P21/c，a=8.150(1)，b=17.763(2)，c=14.630(2) Å，β=103.93(1)°，V=2055.8(3) Å3，Z=4。2 结晶于单斜空间群 P21/c，a=8.141(1)，b=17.175(4)，c=14.810(3) Å，β=103.27(1)°，V=2015.5(7) Å3，Z=4。两个配合物中的金属原子均以四面体几何形状配位，两个配合物以头尾相接的方式排列，形成一个二聚体。

  DOI：

  10.1248/cpb.41.1691

文献信息

• A method of sensitizing multidrug resistant cells to antitumor agents
  申请人：YALE UNIVERSITY

  公开号：EP0361485A2

  公开（公告）日：1990-04-04

  A method for sensitizing multidrug resistant cells to antitumor agents comprising contacting multidrug resistant cells, with an effective amount of a compound of the formula wherein n is 1, 2 or 3, X is CF₃, -O-CH₃, Br, I, Cl, H, W and S-CH₃ and R¹ and R², independently of each other are -CH₃-CH₂-CH₃, CH₂CH₂OHCH₂OH, or NR¹ R² form a ring wherein R³ is -CH₃, CH₂-CH₃,-H, CH₂OH and CH₂CH₂OH.

  一种使耐多药细胞对抗肿瘤药物敏感的方法，包括使耐多药细胞与有效量的式化合物接触 其中 n 为 1、2 或 3、 X 是 CF₃、-O-CH₃、Br、I、Cl、H、W 和 S-CH₃ R¹ 和 R² 相互独立地为-CH₃-CH₂-CH₃、CH₂CH₂OHCH₂OH 或 NR¹ R² 形成一个环 其中 R³ 是 -CH₃、CH₂-CH₃、-H、CH₂OH 和 CH₂CH₂OH。
• Mild and Selective Oxygenation of Sulfides to Sulfoxides and Sulfones by Perfluoro-cis-2,3-dialkyloxaziridines
  作者：Darryl D. DesMarteau、Viacheslav A. Petrov、Vittorio Montanari、Massimo Pregnolato、Giuseppe Resnati

  DOI：10.1021/jo00089a020

  日期：1994.5

  Sulfides are oxidized to sulfoxides by stoichiometric amounts of perfluoro-cis-2,3-dialkyloxaziridines 2. The reactions proceed at -40 degrees C with nearly complete selectivity and very good yields. Sulfoxides are also oxidized easily by 2 under mild conditions to corresponding sulfones. The oxidation of some bioactive sulfides (promazine, albendazole, biotin, and others) is also reported.
• Kuzmicka, L.; Puzanowska-Tarasiewicz, H.; Tarasiewicz, M., Pharmazie, 1988, vol. 43, # 4, p. 288 - 289
  作者：Kuzmicka, L.、Puzanowska-Tarasiewicz, H.、Tarasiewicz, M.

  DOI：——

  日期：——
• Oxidation of psychotropic drugs by Chloramine-T in acid medium: a kinetic study using spectrophotometry
  作者：R.J.D. Saldanha、S. Ananda、B.M. Venkatesha、N.M. Made Gowda

  DOI：10.1016/s0022-2860(01)00859-6

  日期：2002.3

  The kinetics of oxidation of psychotropic drugs, chlorpromazine hydrochloride (CPH) and fluphenazine dihydrochloride (FPH), by Chloramine-T (CAT) in pH 1.6 buffer medium has been studied spectrophotometrically at lambda(max) = 570 and 530 nm, respectively, at 30degreesC. The reaction rate shows a fractional-order dependence on [CAT] and first-order dependence on each [substrate]. The reaction rate also shows an inverse fractional-order in [H+]. Additions of halide ions and the reduction product of CAT, p-toluenesulfonamide, and variation of ionic strength and dielectric constant of the medium do not have any significant effect on the reaction rate. The activation parameters for the reaction were evaluated. The proposed general mechanism and the derived rate law are consistent with the observed kinetics. (C) 2002 Elsevier Science B.V. All rights reserved.
• US5104858A
  申请人：——

  公开号：US5104858A

  公开（公告）日：1992-04-14