1-甲基-5-苯基咪唑烷-2,4-二酮 | 6637-17-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 1-甲基-5-苯基咪唑烷-2,4-二酮
• 英文名称: 1-methyl-5-phenyl-imidazolidine-2,4-dione
• 英文别名: 1-Methyl-5-phenyl-imidazolidin-2,4-dion；1-Methyl-5-phenylimidazolidine-2,4-dione
• CAS: 6637-17-8
• 化学式: C₁₀H₁₀N₂O₂
• 分子量: 190.202
• InChiKey: BQOZLHCBLCBXOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  potassium cyanate 、 alkaline earth salt of/the/ methylsulfuric acid 在 水 作用下， 生成 1-甲基-5-苯基咪唑烷-2,4-二酮
  参考文献：
  名称：

  Gabriel, Justus Liebigs Annalen der Chemie, 1906, vol. 350, p. 121

  摘要：

  DOI：

文献信息

• Compositions and methods for treating respiratory depression with fenfluramine
  申请人：ZOGENIX INTERNATIONAL LIMITED

  公开号：US10952976B2

  公开（公告）日：2021-03-23

  5-HT receptor agonists are useful in the treatment of a variety of diseases. Provided herein are methods of treating and/or reducing the occurrence of respiratory depression caused by an opioid in a human patient or patient population using a 5-HT receptor agonist, such as, for example, a 5-HT4 agonist (e.g., fenfluramine). Methods of stimulating one or more 5-HT4 receptors in the brain of a patient undergoing treatment with an opioid, wherein the patient is at risk of respiratory depression, by administering a 5-HT4 agonist (e.g., fenfluramine) to a subject in need thereof are provided. Pharmaceutical compositions for use in practicing the subject methods are also provided.

  5-HT 受体激动剂可用于治疗多种疾病。本文提供了使用5-HT受体激动剂，例如5-HT4激动剂（如芬氟拉明）治疗和/或减少人类患者或患者群体中阿片类药物引起的呼吸抑制发生的方法。本发明提供了通过向有需要的受试者施用5-HT4激动剂（如芬氟拉明）来刺激正在接受阿片类药物治疗的患者大脑中的一种或多种5-HT4受体的方法，其中患者有呼吸抑制的风险。还提供了用于实施上述方法的药物组合物。
• The Synthesis of 1-R-5-R'-5-Phenylhydantoins
  作者：Loren M. Long、C. A. Miller、H. D. Troutman

  DOI：10.1021/ja01183a005

  日期：1948.3
• METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
  申请人：The Rockefeller University

  公开号：EP3402477A2

  公开（公告）日：2018-11-21
• COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY DEPRESSION WITH FENFLURAMINE
  申请人：ZOGENIX INTERNATIONAL LIMITED

  公开号：US20200330406A1

  公开（公告）日：2020-10-22

  5-HT receptor agonists are useful in the treatment of a variety of diseases. Provided herein are methods of treating and/or reducing the occurrence of respiratory depression caused by an opioid in a human patient or patient population using a 5-HT receptor agonist, such as, for example, a 5-HT4 agonist (e.g., fenfluramine). Methods of stimulating one or more 5-HT 4 receptors in the brain of a patient undergoing treatment with an opioid, wherein the patient is at risk of respiratory depression, by administering a 5-HT4 agonist (e.g., fenfluramine) to a subject in need thereof are provided. Pharmaceutical compositions for use in practicing the subject methods are also provided.
• [EN] PROCESS FOR PRODUCING POLYOXYMETHYLENE POLYMERS WITH LONG-CHAIN ALKYL END GROUPS, AND POLYMERS MADE THEREFROM<br/>[FR] PROCÉDÉ DE PRODUCTION DE POLYMÈRES DE POLYOXYMÉTHYLÈNE COMPORTANT DES GROUPES TERMINAUX ALKYLE À CHAÎNE LONGUE ET POLYMÈRES FABRIQUÉS PAR CE PROCÉDÉ
  申请人：TICONA GMBH

  公开号：WO2014102695A2

  公开（公告）日：2014-07-03

  A polyoxymethylene polymer is disclosed that contains long-chain alkyl end groups. The polyoxymethylene polymer may be formed by using a Bis-alkylformal as a chain transfer agent during production of the polymer. In one embodiment, the Bis-alkylformal is dissolved In a monomer, such as trioxane, during production of the polymer. In one embodiment a branching agent may also be present with one or more monomers for producing a branched polyoxymethylene polymer. In this manner, greater amounts of alkyl end groups can be incorporated into the polymer. The resulting polymer has excellent flow characteristics. The polymer may be used to form various molded articles with excellent tribological properties.