1-羟基-2,3-二甲基-4-亚硝基苯 | 74783-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 1-羟基-2,3-二甲基-4-亚硝基苯
• 英文名称: 2,3-dimethyl-4-nitrosophenol
• CAS: 74783-54-3
• 化学式: C₈H₉NO₂
• mdl: MFCD03931841
• 分子量: 151.165
• InChiKey: MHURFZVFYYDDNL-UHFFFAOYSA-N

物化性质

• 沸点：
  315.5±42.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-羟基-2,3-二甲基-4-亚硝基苯 在 ammonium hydroxide 、 硫化氢 、 sodium ethanolate 作用下， 以 乙醇 、 水 为溶剂， 反应 1.17h， 生成 4-acetamino-1-methoxy-2,3-dimethylbenzene
  参考文献：
  名称：

  4-脱氧卡巴唑霉素 B 的合成：一种方便的替代品

  摘要：

  4-脱氧卡马霉素 B(3) 是通过 4-甲氧基-2,3-二甲基乙酰苯胺 (8) 与溴苯在碘化亚铜和碳酸钾存在下缩合，然后用 20% KOH 乙醇水溶液水解，然后环化合成的在乙酸中用乙酸钯得到取代的二苯胺(9)。

  DOI：

  10.1081/scc-100104069
• 作为产物：
  描述：

  二甲酚 在 盐酸 、 sodium nitrite 作用下， 以 乙醇 为溶剂， 以63.5%的产率得到1-羟基-2,3-二甲基-4-亚硝基苯
  参考文献：
  名称：

  4-脱氧卡巴唑霉素 B 的合成：一种方便的替代品

  摘要：

  4-脱氧卡马霉素 B(3) 是通过 4-甲氧基-2,3-二甲基乙酰苯胺 (8) 与溴苯在碘化亚铜和碳酸钾存在下缩合，然后用 20% KOH 乙醇水溶液水解，然后环化合成的在乙酸中用乙酸钯得到取代的二苯胺(9)。

  DOI：

  10.1081/scc-100104069

文献信息

• PROCESS FOR PREPARING 1, 2-BENZENEDIMETHANOL COMPOUND
  申请人：GOWAN COMPANY, L.L.C.

  公开号：US20200399263A1

  公开（公告）日：2020-12-24

  A process for preparing a compound represented by Formula [1], the process comprising a step of hydrolyzing a compound represented by Formula [2] under an acidic or basic condition, and a step of reacting a compound represented by Formula [3] with a metal acetate salt, and a step of halogenating a compound represented by Formula [4]; a process for preparing a compound represented by Formula [1] comprising a step of reacting a compound represented by Formula [3] with a metal acetate salt, and then, adding alcohol, water, or base to the reaction solution to perform reaction; a process for preparing a compound represented by Formula [1] comprising a step of reacting a compound represented by Formula [3] under a presence or absence of a base, an ionic liquid and a metal sulfate salt, in water or a mixed solvent of water and an organic solvent; a compound represented by Formula [2] or a salt of the same; and a compound represented by Formula [3] or a salt of the same.

  制备由化学式[1]表示的化合物的方法，包括在酸性或碱性条件下水解由化学式[2]表示的化合物的步骤，以及与金属醋酸盐反应由化学式[3]表示的化合物的步骤，以及卤代由化学式[4]表示的化合物的步骤；制备由化学式[1]表示的化合物的方法，包括将由化学式[3]表示的化合物与金属醋酸盐反应的步骤，然后向反应溶液中加入醇、水或碱来进行反应；制备由化学式[1]表示的化合物的方法，包括在水或水和有机溶剂的混合溶剂中，在存在或缺乏碱、离子液体和金属硫酸盐的情况下，将由化学式[3]表示的化合物进行反应的步骤；由化学式[2]表示的化合物或其盐；以及由化学式[3]表示的化合物或其盐。
• METHOD FOR PRODUCING 1, 2-BENZENE DIMETHANOL COMPOUND
  申请人：SDS Biotech K. K.

  公开号：EP3415496A1

  公开（公告）日：2018-12-19

  The present invention relates to: a method for producing a compound represented by formula (1), which comprises a step for hydrolyzing a compound represented by formula (2) under acidic or basic conditions, a step for reacting a compound represented by formula (3) and a metal acetate salt with each other, and a step for halogenating a compound represented by formula (4); a method for producing a compound represented by formula (1), which comprises a step for reacting a compound represented by formula (3) and a metal acetate salt with each other and then causing a further reaction by adding an alcohol, water and a base into the resulting reaction liquid; a method for producing a compound represented by formula (1), which comprises a step for causing a reac - tion of a compound represented by formula (3) in the presence or absence of a base, an ionic liquid and a metal sulfate salt in water or in a mixed solvent of water and an organic solvent; a compound represented by formula (2) or a salt thereof; and a compound represented by formula (3) or a salt thereof.

  本发明涉及一种生产式(1)所代表化合物的方法，该方法包括在酸性或碱性条件下水解式(2)所代表化合物的步骤、使式(3)所代表化合物和乙酸金属盐相互反应的步骤，以及卤化式(4)所代表化合物的步骤；一种生产式(1)所代表化合物的方法，其中包括使式(3)所代表化合物和乙酸金属盐相互反应，然后通过向生成的反应液中加入醇、水和碱而进一步反应的步骤；一种生产由式（1）代表的化合物的方法，其中包括一个步骤，使由式（3）代表的化合物在碱存在或不存在的情况下，在水中或在水和有机溶剂的混合溶剂中发生反应；由式（2）代表的化合物或其盐类；以及由式（3）代表的化合物或其盐类。
• Homogeneous anaerobically stable quantum dot concentrates
  申请人：Nanosys, Inc.

  公开号：US10919770B2

  公开（公告）日：2021-02-16

  The present disclosure provides nanostructure compositions and methods of producing nanostructure compositions. The nanostructure compositions comprise at least one population of nanostructures, at least one reactive diluent, at least one anaerobic stabilizer, and optionally at least one organic resin. The present disclosure also provides nanostructure films comprising a nanostructure layer and methods of making nanostructure films.

  本公开提供了纳米结构组合物和生产纳米结构组合物的方法。纳米结构组合物包括至少一种纳米结构群、至少一种活性稀释剂、至少一种厌氧稳定剂和可选的至少一种有机树脂。本公开还提供了包含纳米结构层的纳米结构薄膜和制造纳米结构薄膜的方法。
• Process for preparing 1, 2-benzenedimethanol compound
  申请人：GOWAN COMPANY, L.L.C.

  公开号：US11274076B2

  公开（公告）日：2022-03-15

  A process for preparing a compound represented by Formula [1], the process comprising a step of hydrolyzing a compound represented by Formula [2] under an acidic or basic condition, and a step of reacting a compound represented by Formula [3] with a metal acetate salt, and a step of halogenating a compound represented by Formula [4]; a process for preparing a compound represented by Formula [1] comprising a step of reacting a compound represented by Formula [3] with a metal acetate salt, and then, adding alcohol, water, or base to the reaction solution to perform reaction; a process for preparing a compound represented by Formula [1] comprising a step of reacting a compound represented by Formula [3] under a presence or absence of a base, an ionic liquid and a metal sulfate salt, in water or a mixed solvent of water and an organic solvent; a compound represented by Formula [2] or a salt of the same; and a compound represented by Formula [3] or a salt of the same.

  一种制备由式[1]代表的化合物的工艺，该工艺包括在酸性或碱性条件下水解由式[2]代表的化合物的步骤，以及由式[3]代表的化合物与金属醋酸盐反应的步骤，和卤化由式[4]代表的化合物的步骤；一种制备由式[1]代表的化合物的工艺，该工艺包括由式[3]代表的化合物与金属醋酸盐反应的步骤，然后，在反应溶液中加入醇、水或碱以进行反应；一种制备由式[1]代表的化合物的工艺，包括在碱存在或不存在的情况下，在水或水和有机溶剂的混合溶剂中使由式[3]代表的化合物、由式[2]代表的化合物或其盐以及由式[3]代表的化合物或其盐反应的步骤。
• Saha; Chakraborty; Chowdhury, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 677 - 680
  作者：Saha、Chakraborty、Chowdhury

  DOI：——

  日期：——