1-苄基-3-(4-氯苯基)吡咯烷 | 231622-37-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-苄基-3-(4-氯苯基)吡咯烷
• 英文名称: 1-Benzyl-3-(4-chlorophenyl)pyrrolidine
• 英文别名: 1-benzyl-3-(4-chlorophenyl)pyrrolidine
• CAS: 231622-37-0
• 化学式: C₁₇H₁₈ClN
• mdl: MFCD28108525
• 分子量: 271.79
• InChiKey: UMXYVXBAUAGHIK-UHFFFAOYSA-N

物化性质

• 沸点：
  374.7±37.0 °C(Predicted)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.294
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-苄基-3-(4-氯苯基)吡咯烷 在 palladium on activated charcoal ammonium formate 作用下， 以 甲醇 为溶剂， 生成 3-(4-氯苯基)吡咯烷
  参考文献：
  名称：

  N-Substituted-3-arylpyrrolidines: Potent and selective ligands at serotonin 1A receptor

  摘要：

  3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00201-2
• 作为产物：
  描述：

  N-苄基-3-吡咯烷醇 在 4-二甲氨基吡啶 、 copper(I) bromide dimethylsulfide complex 作用下， 以 乙腈 为溶剂， 反应 1.42h， 生成 1-苄基-3-(4-氯苯基)吡咯烷
  参考文献：
  名称：

  N-Substituted-3-arylpyrrolidines: Potent and selective ligands at serotonin 1A receptor

  摘要：

  3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00201-2

文献信息

• N-Substituted-3-arylpyrrolidines: Potent and selective ligands at serotonin 1A receptor
  作者：Kyo Han Ahn、Seok Jong Lee、Chang-Ho Lee、Chang Y. Hong、Tae Kyo Park

  DOI：10.1016/s0960-894x(99)00201-2

  日期：1999.5

  3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents. (C) 1999 Elsevier Science Ltd. All rights reserved.