1-苯胺基吡咯烷-2,5-二酮 | 61152-66-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-苯胺基吡咯烷-2,5-二酮
• 英文名称: 1-(phenylamino)pyrrolidine-2,5-dione
• 英文别名: 2,5-Pyrrolidinedione, 1-(phenylamino)-；1-anilinopyrrolidine-2,5-dione
• CAS: 61152-66-7
• 化学式: C₁₀H₁₀N₂O₂
• 分子量: 190.202
• InChiKey: QIRVXYCWIWAETK-UHFFFAOYSA-N

物化性质

• 熔点：
  158-159 °C(Solv: ethanol (64-17-5))
• 沸点：
  313.8±25.0 °C(Predicted)
• 密度：
  1.381±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-苯胺基吡咯烷-2,5-二酮 在 lead(IV) acetate 、 三氟乙酸 作用下， 反应 0.02h， 生成
  参考文献：
  名称：

  Radical products of the oxidation of 2,2-diacyl-1-arylhydrazines with the system Pb(OAc)4-CF3COOH-CH2Cl2

  摘要：

  The oxidation of 2,2-Diacyl-1-arylhydrazines 1a-l with the system Pb(OAc)(4)-CF3COOH-CH2Cl2 led to the formation of two types of radical products. Phenazinium cation radicals 5a-h were formed from 2,2-diacyl-1-arylhydrazines 1a-h, while hydrazyl radicals 2i-l were observed to be the only radical products of the oxidation of 1i-l. The generated radicals are characterized by their EPR parameters.

  DOI：

  10.1007/bf00812244
• 作为产物：
  描述：

  4-羰基-4-(2-苯基肼基 生成 1-苯胺基吡咯烷-2,5-二酮
  参考文献：
  名称：

  Auger, Annales de Chimie (Cachan, France), 1891, vol. <6> 22, p. 339

  摘要：

  DOI：

文献信息

• Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
  申请人：Miller Scott

  公开号：US20080269265A1

  公开（公告）日：2008-10-30

  This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

  这项发明涉及使用一组芳基脲类化合物治疗raf介导的疾病，以及用于该疗法的药物组合物。
• Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
  申请人：BAYER CORPORATION

  公开号：US20040102636A1

  公开（公告）日：2004-05-27

  This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.

  这项发明涉及使用一组芳基脲类化合物治疗细胞因子介导的疾病和蛋白酶酶介导的疾病，以及用于该疗法的药物组合物。
• [EN] ECO-FRIENDLY MATERIALS AND METHODS FOR RENEWABLE AND SUSTAINABLE APPLICATIONS IN MATERIAL CHEMISTRY<br/>[FR] MATÉRIAUX ET PROCÉDÉS RESPECTUEUX DE L'ENVIRONNEMENT POUR DES APPLICATIONS RENOUVELABLES ET DURABLES DANS LA CHIMIE DES MATÉRIAUX
  申请人：NDSU RES FOUND

  公开号：WO2017156066A1

  公开（公告）日：2017-09-14

  The invention relates to novel hydrazide-based templates, methods of making the same, and methods of using the hydrazide-based templates as molecular scaffolds for asymmetric light driven transformations, light driven material synthesis, and biological applications. Furthermore, the present invention relates to photoinitiators, monomers, and polymers derived from biomass, together with methods and methods of using the same.

  该发明涉及新型基于肼酰肼的模板，制备方法以及将基于肼酰肼的模板用作不对称光驱动转化、光驱动材料合成和生物应用的分子支架的方法。此外，本发明涉及从生物质衍生的光引发剂、单体和聚合物，以及使用它们的方法。
• Method for the preparation of quinoline-2,3-dicarboxylic acid
  申请人：American Cyanamid Company

  公开号：US04757146A1

  公开（公告）日：1988-07-12

  The present invention relates to novel methods for the preparation of quinoline-2,3-dicarboxylic acid, useful for the preparation of the highly effective 2-(2-imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.

  本发明涉及一种新的制备喹啉-2,3-二甲酸的方法，用于制备高效的2-(2-咪唑啉-2-基)喹啉-3-甲酸除草剂。
• Simple and efficient synthesis of N-alkyl and N-aryl succinimides in hot water
  作者：Burcu Bozdoğan、Mehmet Erşatır、Onur Demirkol、Dilek Akbaşlar、E. Sultan Giray

  DOI：10.1080/00397911.2016.1258479

  日期：2017.2.1

  ABSTRACT A new, simple synthesis of succinimides is described. The reactions were carried out under the ultimate green conditions excluding both catalyst and organic solvent by applying simple stirring at 100 °C. A wide variety of N-susbstituted succinimides have been prepared in high yields by using succinic acid and primary amines in hot water. Yield of N-alkyl substituted succinimides were found

  摘要描述了一种新的、简单的琥珀酰亚胺合成方法。反应在最终绿色条件下进行，不包括催化剂和有机溶剂，在 100 °C 下进行简单搅拌。已经通过在热水中使用琥珀酸和伯胺以高产率制备了多种 N-取代的琥珀酰亚胺。发现N-烷基取代的琥珀酰亚胺的产率高于N-芳基取代的琥珀酰亚胺的产率。图形概要