1-萘甲胺,N-(2-甲基丙基)- | 14489-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-萘甲胺,N-(2-甲基丙基)-
• 英文名称: N-i-Butyl-1-naphthylmethylamin
• 英文别名: 2-methyl-N-(naphthalen-1-ylmethyl)propan-1-amine
• CAS: 14489-79-3
• 化学式: C₁₅H₁₉N
• mdl: MFCD04502368
• 分子量: 213.323
• InChiKey: TVZCPMDWMZEUDM-UHFFFAOYSA-N

物化性质

• 沸点：
  328.7±11.0 °C(Predicted)
• 密度：
  0.991±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-萘甲醇 、 异丁胺 在 manganese(IV) oxide 、 sodium tetrahydroborate 、 甲醇 作用下， 以 二氯甲烷 为溶剂， 反应 0.67h， 以78%的产率得到1-萘甲胺,N-(2-甲基丙基)-
  参考文献：
  名称：

  A one-pot oxidation–imine formation–reduction route from alcohols to amines using manganese dioxide–sodium borohydride: the synthesis of naftifine

  摘要：

  A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01722-7

文献信息

• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150322008A1

  公开（公告）日：2015-11-12

  The invention relates to indole carboxamide derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  本发明涉及公式（I）中的吲哚羧酰胺衍生物，其中R1、R2、R3、R4、R5和R6如描述中所定义，其制备和用作药学活性化合物。
• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2931717B1

  公开（公告）日：2016-12-07
• US9718774B2
  申请人：——

  公开号：US9718774B2

  公开（公告）日：2017-08-01
• A one-pot oxidation–imine formation–reduction route from alcohols to amines using manganese dioxide–sodium borohydride: the synthesis of naftifine
  作者：Hisashi Kanno、Richard J.K. Taylor

  DOI：10.1016/s0040-4039(02)01722-7

  日期：2002.10

  A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine. (C) 2002 Elsevier Science Ltd. All rights reserved.