15-甲基十六碳二氢鸟嘌呤 | 26048-10-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 15-甲基十六碳二氢鸟嘌呤
• 英文名称: (2S,3R)-2-amino-1,3-dihydroxy-15-methylhexadecanoate
• 英文别名: 15-Methylhexadecasphinganine；(2S,3R)-2-amino-15-methylhexadecane-1,3-diol
• CAS: 26048-10-2
• 化学式: C₁₇H₃₇NO₂
• 分子量: 287.486
• InChiKey: VFYHIOGWELBGIK-DLBZAZTESA-N

物化性质

• 熔点：
  58-61?C
• 沸点：
  428.4±25.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少量，加热），甲醇（少量，超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  15-甲基十六碳二氢鸟嘌呤 在 10 wt% Pd(OH)2 on carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以42%的产率得到
  参考文献：
  名称：

  Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans

  摘要：

  线虫特异性异支链鞘氨醇基合成：寄生虫药物靶点和人类疾病遗传模型系统。

  DOI：

  10.1039/c6sc04831e
• 作为产物：
  描述：

  在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 以58%的产率得到15-甲基十六碳二氢鸟嘌呤
  参考文献：
  名称：

  Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans

  摘要：

  线虫特异性异支链鞘氨醇基合成：寄生虫药物靶点和人类疾病遗传模型系统。

  DOI：

  10.1039/c6sc04831e

文献信息

• [EN] GLYCOSPHINGOLIPIDS FOR USE IN MODULATING IMMUNE RESPONSES<br/>[FR] GLYCOSPHINGOLIPIDES UTILES À LA MODULATION DES RÉPONSES IMMUNITAIRES
  申请人：UNIV CALIFORNIA

  公开号：WO2013119857A1

  公开（公告）日：2013-08-15

  Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.

  本文提供了可用于激活自然杀伤T细胞的鞘脂化合物。同时，还提供了通过刺激自然杀伤T细胞激活免疫系统来治疗或预防可治疗的疾病或疾病的方法。因此，这些化合物可用于治疗或减少免疫性疾病和疾病的发生可能性，如自身免疫性疾病或疾病。这些化合物也可用于通过给予所述鞘脂化合物来治疗或减少受试者微生物感染的可能性或治疗或减少受试者癌症发生的可能性。
• Glycosphingolipids for use in modulating immune responses
  申请人：The Regents of the University of California

  公开号：US10227290B2

  公开（公告）日：2019-03-12

  Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.

  本文提供了可用于激活自然杀伤 T 细胞的鞘脂化合物。还提供了治疗或预防可通过刺激自然杀伤 T 细胞激活免疫系统来治疗的疾病或紊乱的方法。因此，这些化合物可用于治疗或降低免疫性疾病和失调（如自身免疫性疾病或失调）发生的可能性。这些化合物还可用于治疗或降低微生物感染发生的可能性，或通过施用本文所述的鞘脂化合物治疗或降低受试者癌症发生的可能性。
• GLYCOSPHINGOLIPIDS FOR USE IN MODULATING IMMUNE RESPONSES
  申请人：The Regents of the University of California

  公开号：US20140377291A1

  公开（公告）日：2014-12-25

  Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
• Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans
  作者：J. Thomas Hannich、Denia Mellal、Suihan Feng、Andreas Zumbuehl、Howard Riezman

  DOI：10.1039/c6sc04831e

  日期：——

  Nematode-specific iso-branched sphingoid base synthesis: drug-target against parasites and genetic model system for human diseases.

  线虫特异性异支链鞘氨醇基合成：寄生虫药物靶点和人类疾病遗传模型系统。