1H-咪唑,2-(1-氯-2,2-二甲基丙基)- | 301856-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1H-咪唑,2-(1-氯-2,2-二甲基丙基)-
• 中文别名: 3-硝基-4-(三氟甲基)苯磺酰氯
• 英文名称: 3-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride
• 英文别名: 3-nitro-4-(trifluoromethyl)benzenesulfonyl chloride
• CAS: 301856-45-1
• 化学式: C7H3ClF3NO4S
• 分子量: 289.62
• InChiKey: GDJPESFQLZUZMS-UHFFFAOYSA-N

物化性质

• 沸点：
  337.8±42.0 °C(Predicted)
• 密度：
  1.689±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF
  申请人：Rigby Alan C.

  公开号：US20140088187A1

  公开（公告）日：2014-03-27

  The present invention relates to novel aryl sulfonamide compounds use of such compounds in the inhibition of androgen receptor and in the treatment of various diseases, disorders or conditions related to androgen receptor.

  本发明涉及新型芳基磺酰胺化合物，以及这些化合物在抑制雄激素受体和治疗与雄激素受体相关的各种疾病、障碍或病况中的应用。
• PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY
  申请人：NPS Allelix Corp.

  公开号：EP1173432B9

  公开（公告）日：2008-10-15
• US6133287A
  申请人：——

  公开号：US6133287A

  公开（公告）日：2000-10-17
• [EN] PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY<br/>[FR] COMPOSES PIPERIDINE-INDOL AYANT UNE AFFINITE AVEC 5-HT6
  申请人：ALLELIX BIOPHARMA

  公开号：WO2000063203A1

  公开（公告）日：2000-10-26

  Described herein are indole compounds with affinity for the 5-HT6 receptor, which have general formula (I) wherein, R1 is selected from the group consisting of H and C¿1-4?alkyl; R?2¿ is selected from the group consisting of H, C¿1-4?alkyl and benzyl; ----- represents a single or double bond; R?3¿ is selected from the group consisting of COR5 and SO¿2?R?5; R4a¿ is selected from the group consisting of H, OH, halo, C¿1-4?alkyl and C1-4alkoxy; R?4b¿ is selected from the group consisting of H, hydroxy, halo, C¿3-7?cycloalkyloxy, C1-4alkoxy, C1-4alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl; R?4c¿ is selected from the group consisting of H, OH, halo, C¿1-4?alkyl and C1-4alkoxy; R?4d¿ is selected from the group consisting of H, OH, halo, C¿1-4?alkyl and C1-4alkoxy; and R?5¿ is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C¿1-4?alkoxy, C1-4alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C1-4alkylcarbonyl, C1-4alkoxycarbonyl and C1-4alkylS-. Also described is the use of the compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
• [EN] ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DU RÉCEPTEUR DES ANDROGÈNES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BETH ISRAEL HOSPITAL

  公开号：WO2012082862A2

  公开（公告）日：2012-06-21

  The present invention relates to novel aryl sulfonamide compounds use of such compounds in the inhibition of angrogen receptor and in the treatment of various diseases, disorders or conditions related to androgen receptor.