2,2'-(甲基亚胺)二乙醇盐酸盐 | 54060-15-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2,2'-(甲基亚胺)二乙醇盐酸盐
• 英文名称: N-methyldiethanolamine hydrochloride
• 英文别名: N-methyl-2,2'-aminodiethanol hydrochloride；N-methyldiethanolammonium chloride；2-[2-hydroxyethyl(methyl)amino]ethanol hydrochloride；2,2'-(methylimino)bisethanol hydrochloride；hydron;2-[2-hydroxyethyl(methyl)amino]ethanol;chloride
• CAS: 54060-15-0
• 化学式: C₅H₁₃NO₂*ClH
• 分子量: 155.625
• InChiKey: CMPOVQUVPYXEBN-UHFFFAOYSA-N

物化性质

• 密度：
  1.180417 g/cm3(Temp: 30.00 °C)
• 溶解度：
  DMSO（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.68
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  2,2'-(甲基亚胺)二乙醇盐酸盐 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以99%的产率得到恩比兴
  参考文献：
  名称：

  ‘3+1' Mixed-Ligand Oxotechnetium(V) Complexes with Affinity for Melanoma:  Synthesis and Evaluation in Vitro and in Vivo

  摘要：

  **'3+1'型杂配位体[Tc-99m]氧肟technetium复合物的合成及其对黑色素瘤的靶向性研究** 在一步锅法反应中，成功合成了一种对黑色素瘤具有亲和力的'3+1'型杂配位体 [Tc-99m]oxotechnetium 复合物。通过将 technetium-99m 与 N-R（3-氮杂戊烷-1,5-二硫醇）[R = Me, Pr, Bn, Et2N(CH2)2] 和 N-(2-双烷基氨基)乙烷硫醇 [烷基 = X = Et, Bu, 吗啉基] 的混合物中的 technetium-99m 复合，并使用 Sn²+ 作为还原剂，最终形成了'3+1'型杂配位体 technetium-99m 复合物 [TcO(SN(R)S)(SNX2)]，其放射化学产率高达 60-98% 。 体外实验中，利用 B16 小鼠黑色素瘤细胞进行的摄取研究表明，化合物 1 [R = Me, X = Et] 在60 分钟孵育后的肿瘤细胞积聚量为 40%，而化合物 2 [R = Me, X = Bu] 则达到了 69% 的较高积聚量。在 C57B16/B16 小鼠黑色素瘤模型中，对化合物 1-6 进行的体内评估显示，这些化合物均表现出肿瘤定位能力。其中，化合物 2 在注射后60 分钟内达到最高的积聚量，为 5% ID/g 。 进一步的体内研究表明，化合物 2 在1 小时时表现出较低的血液活性，并且其黑色素瘤/脾脏（4.3）和黑色素瘤/肺（1.9）比值显著升高。这些结果表明，小巧的 technetium-99m 复合物有望成为潜在的黑色素瘤成像剂。

  DOI：

  10.1021/jm000050e
• 作为产物：
  描述：

  N-甲基二乙醇胺 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 24.99 ℃ 、101.0 kPa 条件下， 反应 12.0h， 生成 2,2'-(甲基亚胺)二乙醇盐酸盐
  参考文献：
  名称：

  Density, Viscosity, and Performances of Carbon Dioxide Capture in 16 Absorbents of Amine + Ionic Liquid + H₂O, Ionic Liquid + H₂O, and Amine + H₂O Systems

  摘要：

  A series of novel ionic liquids, 2-aminoethanol tetrafluoroborate ([MEM][BF4]), 2[2-hydroxyethyl(methyl)-amino] ethanol tetrafluoroborate ([MDEA][BF4]), 2[2-hydroxyethyl(methyl)amino] ethanol chloride ([MDEA][Cl]), 2[2-hydroxyethyl(methyl)amino] ethanol phosphate ([MDEA] [PO4]), and 2-[2-hydroxyethyl(methyl)amino] ethanol sulfate ([MDEA][SO4]), were synthesized and characterized for carbon dioxide capture in this work. Densities and viscosities of ionic liquids (1-butyl-3-methylimidazolium tetrafluoroborate, [MEA][BF4], [MDEA][BF4], [MDEA][Cl], and [MDEA][PO4], and [MDEA][SO4]) amines + ionic liquids + H2O, ionic liquids + H2O, and amines + H2O were measured at temperatures ranging from (303.15 to 343.15) K at different mass fractions. These 16 different absorbents were prepared by mixing two or three compounds of 2-aminoethanol (MEA), 2[2-hydroxyethyl(methyl)amino] ethanol (MDEA), 2-[bis(2-hydroxyethyl)amino] ethanol (TEA), ionic liquids, and water. The carbon dioxide capture rate and carbon dioxide capture capacity in the 16 different absorbents were measured at 303.15 K and 1.50 MPa. The experimental results showed that the viscosities of these absorbents are less than 17.00 mPa . s at 303.15 K. Among these absorbents, the MDEA + [MDEAl][Cl] + H2O + piperazine system shows the best performance on carbon dioxide capture.

  DOI：

  10.1021/je100078w

文献信息

• Ruthenium-catalyzed heteroannulation of anilines with alkanolammonium chlorides leading to indoles
  作者：Chan Sik Cho、Jin Hwang Kim、Tae-Jeong Kim、Sang Chul Shim

  DOI：10.1016/s0040-4020(01)00202-2

  日期：2001.4

  Anilines react with alkanolammonium chlorides in an aqueous medium (H2O–dioxane) at 180°C in the presence of a catalytic amount of a ruthenium catalyst together with SnCl2·2H2O to afford the corresponding indoles in moderate to good yields. Especially, when triisopropanolammonium chloride is employed to react with anilines, 2-methylindoles are formed regioselectively. The presence of SnCl2·2H2O is

  在催化量的钌催化剂和SnCl 2 ·2H 2 O的存在下，苯胺在水性介质（H 2 O-二恶烷）中在180°C下与链烷醇氯化铵反应，以中等至良好的收率得到相应的吲哚。特别是，当使用氯化三异丙基丙铵与苯胺反应时，区域选择性地形成2-甲基吲哚。的SnCl存在2 ·2H 2 O为必需的有效形成吲哚。针对该催化过程，提出了一种涉及链烷醇基团从链烷醇胺转移至苯胺，苯胺被苯胺链烷醇进行N-烷基化以及1,2-二苯胺基烷烃的杂环化反应的反应途径。
• Tricyclo compounds, a process for their production and pharmaceutical composition containing the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：US20030229115A1

  公开（公告）日：2003-12-11

  This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: 1 to a process for their reproduction, to a pharmaceutical composition containing the same and to a use thereof.

  本发明涉及用于治疗和预防移植抗拒、骨髓移植引起的移植物抗宿主病、自身免疫疾病、感染性疾病等的三环化合物，可以用以下公式表示：1，以及其复制过程、含有其的制药组合物和使用方法。
• Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
  申请人：Okuhara Masakuni

  公开号：US20050124646A1

  公开（公告）日：2005-06-09

  This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.

  本发明涉及三环化合物，其可用于治疗和预防移植耐受性、骨髓移植引起的移植物抗宿主病、自身免疫性疾病、感染性疾病等，该化合物可以用以下公式表示：本发明还涉及其制备方法、含有该化合物的药物组合物以及其用途。
• Viscoelastic compositions
  申请人：——

  公开号：US20040102330A1

  公开（公告）日：2004-05-27

  The present invention provides aqueous viscoelastic compositions comprising a cleavable surfactant and possibly also an electrolyte. The cleavable surfactants useful in the present invention comprise at least one weak chemical bond, which is capable of being broken under appropriate conditions, to produce oil soluble and water soluble products typically having no interfacial properties and surface activity compared with the original surfactant molecule. Further, the rheological properties of the aqueous viscolelastic composition are usually altered upon cleavage of the cleavable surfactant generally resulting in the elimination of the viscofying, viscoelastic and surfactant properties of the composition. Aqueous viscoelastic compositions in accordance with the present invention are suitable for use in oil-field applications, particularly for hydraulic fracturing of subterranean formations. Thus, the present invention also relates to a wellbore service fluid and a method of fracturing a subterranean formation. The present invention also concerns novel cleavable surfactants.

  本发明提供了包含可裂解表面活性剂和可能还包含电解质的水性粘弹性组合物。本发明中有用的可裂解表面活性剂包括至少一种弱化学键，它能够在适当条件下被断裂，产生油溶性和水溶性产物，通常与原始表面活性剂分子相比没有界面性和表面活性。此外，水性粘弹性组合物的流变性质通常在可裂解表面活性剂解离后发生改变，通常导致组合物的粘性、粘弹性和表面活性特性的消失。根据本发明的水性粘弹性组合物适用于油田应用，特别是用于地下地层的水力压裂。因此，本发明还涉及井眼服务液和压裂地下地层的方法。本发明还涉及新颖的可裂解表面活性剂。
• Alkyl ammonium ionomers
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0007758A1

  公开（公告）日：1980-02-06

  Ionomers comprising higher alkyl ammonium or quaternary polyammonium salts of polyacids, particularly sulfonic acids, having anionic groups covalently bonded to carbon atoms comprising a backbone chain of a polymer, or to acyclic, alicyclic or aromatic radicals which are pendant to the backbone chain of the polymer, are novel compositions of matter. These ionomers vary in properties from water-soluble polyelectrolytes useful as thickening agents to thermoplastic elastomers which can be extruded, injection molded, vacuum formed, etc. at elevated temperatures. The elastomers are useful as speciality and general purpose rubbers.

  由聚酸（尤其是磺酸）的高烷基铵盐或季铵盐组成的离子聚合物，其阴离子基团与聚合物骨架链上的碳原子或与聚合物骨架链上的无环、脂环或芳香基共价键合，是一种新型的物质组合物。这些离子聚合物的性质各不相同，既有可用作增稠剂的水溶性聚电解质，也有可在高温下挤压、注塑、真空成型等的热塑性弹性体。这些弹性体可用作特种橡胶和通用橡胶。