氯伏胺 | 54739-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氯伏胺
• 英文名称: Clovoxamine fumarate
• 英文别名: (E)-but-2-enedioic acid;2-[(E)-[1-(4-chlorophenyl)-5-methoxypentylidene]amino]oxyethanamine
• CAS: 54739-21-8
• 化学式: C18H25ClN2O6
• 分子量: 400.9
• InChiKey: HOFGGHPYWKSXTN-QCHLHFLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  8

安全信息

• 海关编码：
  2928000090

文献信息

• Method of preparing tablets with clovoxamine fumarate and tablets thus prepared
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0273487A1

  公开（公告）日：1988-07-06

  The invention relates to a method of preparing tablets containing clovoxamine fumarate as active component by dissolving this active component in a mixture of 25-75% of an alcohol having 1-4 C-atoms and 75-25% of water before it is mixed with the remaining components for granulating, and to tablets so obtained.

  本发明涉及一种以富马酸氯伏沙明为活性成分的片剂的制备方法，该方法是先将这种活性成分溶解在 25-75%具有 1-4 个 C 原子的醇和 75-25%的水的混合物中，然后再与其余成分混合造粒。
• Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
  申请人：The Scripps Research Institute

  公开号：US10660899B2

  公开（公告）日：2020-05-26

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

  本发明提供了用神经递质受体调节剂诱导少突胶质祖细胞向成熟髓鞘细胞命运分化的方法。本发明还提供了通过施用所述神经递质受体调节剂刺激有需要的受试者增加髓鞘化的方法。本发明还提供了使用神经递质受体调节剂治疗脱髓鞘疾病的方法。
• JPS63141925A
  申请人：——

  公开号：JPS63141925A

  公开（公告）日：1988-06-14
• DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE
  申请人：Schultz Peter

  公开号：US20140038949A1

  公开（公告）日：2014-02-06

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
• US4844908A
  申请人：——

  公开号：US4844908A

  公开（公告）日：1989-07-04