N-[3-(methylcarbamoyl)phenyl]-6-phenyl-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-(methylcarbamoyl)phenyl]-6-phenyl-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide
• 化学式: C₂₄H₂₃N₅O₂
• 分子量: 413.5
• InChiKey: VITLGFXLWGGVCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  88.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ANTIBACTERIAL COMPOSITIONS FOR PREVENTING ANTIBIOTIC RESISTANCE IN BACTERIA BY INHIBITION OF SOS RESPONSE<br/>[FR] COMPOSITIONS ANTIBACTÉRIENNES POUR LA PRÉVENTION DE LA RÉSISTANCE AUX ANTIBIOTIQUES DANS DES BACTÉRIES PAR INHIBITION DE LA RÉPONSE SOS
  申请人：TELSCIE GENETICS OPC PRIVATE LTD

  公开号：WO2021156846A1

  公开（公告）日：2021-08-12

  Provided herein are compounds having formula I (MDRD1) and formula II (MDRD2) for use in preventing resistance against antibiotics in bacteria. The compounds MDRD1 and MDRD2 effectively inhibit autoproteolysis of LexA protein in bacteria thereby inhibiting SOS response in bacteria and preventing resistance against antibiotics. Provided herein also are methods and compositions for preventing resistance against antibiotics in bacteria. The compounds MDRD1 and MDRD2 can also be administered along with antibiotics in humans and animals, as antibiotic adjuvants to prevent antibiotic resistance.