2,2’-联噻吩-5-羰酰氯 | 135887-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 中文名称: 2,2’-联噻吩-5-羰酰氯
• 中文别名: 2,2'-联二噻吩-5-甲酰氯；2,2'-联噻吩-5-羰酰氯
• 英文名称: 2,2'-bithienyl-5-carboxylic acid chloride
• 英文别名: [2,2'-bithiophene]-5-carbonyl chloride；5-(2'-thienyl)-2-thenoyl chloride；2,2'-Bithiophene-5-Carbonyl Chloride；5-thiophen-2-ylthiophene-2-carbonyl chloride
• CAS: 135887-26-2
• 化学式: C₉H₅ClOS₂
• mdl: MFCD02681915
• 分子量: 228.723
• InChiKey: HTMFYRRRQQYPCA-UHFFFAOYSA-N

物化性质

• 熔点：
  73.3-74.4

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34
• 危险品运输编号：
  UN 3261
• 海关编码：
  2934999090

SDS

Name:	2 2 -Bithiophene-5-carbonyl chloride 97% Material Safety Data Sheet
Synonym:
CAS:	135887-26-2

Section 1 - Chemical Product MSDS Name:2 2 -Bithiophene-5-carbonyl chloride 97% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
135887-26-2	2,2'-Bithiophene-5-carbonyl chloride	97%	unlisted

Hazard Symbols: C
Risk Phrases: 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Moisture sensitive.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area. Store under an inert atmosphere.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 135887-26-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: green
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 73.3 - 74.4 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H5ClOS2
Molecular Weight: 228.72

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 135887-26-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,2'-Bithiophene-5-carbonyl chloride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.*
Hazard Class: 8
UN Number: 3261
Packing Group: III
IMO
Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3261
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3261
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 135887-26-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 135887-26-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 135887-26-2 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,2'-联二噻吩 、 2,2’-联噻吩-5-羰酰氯 以 二氯甲烷 、 正戊烷 、 苯 为溶剂， 以66%的产率得到di(2,2'-bithiophen-5-yl)methanone
  参考文献：
  名称：

  Photochromic naphtho [2,1-b]pyran compounds containing bithienyl or terthienyl substituents, process for their manufacture, and photochromic materials and articles obtained

  摘要：

  该发明的光致变色化合物对应于以下结构式：其中Th2代表萘环系统中5到10位置的二噻吩基团，R1表示二噻吩或三噻吩基团，R2表示二噻吩、三噻吩、芳基、萘基、噻吩基、呋喃基、吡咯基或N-烷基吡咯基团。

  公开号：

  US06312811B1

文献信息

• Piperazine and homopiperazine compounds
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20030153556A1

  公开（公告）日：2003-08-14

  Compounds are provided having a piperazine or homopiperazine ring which are useful in the treatment of thrombosis.

  提供了具有哌嗪或同源哌嗪环的化合物，这些化合物在治疗血栓症方面很有用。
• Synthesis of 7-deoxycholic amides or cholanes containing distinctive ion-recognizing groups at C3 and C12 and evaluation for ion-selective ionophores
  作者：Jeung Hoon On、Kui Tae Cho、Youngjin Park、Sunmi Hahm、Wook Kim、Joo Young Cho、Ji Hyeon Hwang、Young Moo Jun、Guen Sig Cha、Hakhyun Nam、Byeong Hyo Kim

  DOI：10.1016/j.tet.2008.12.023

  日期：2009.2

  Tweezer-type ionophores containing C3-bipyridyl and C12-dithiocarbamoyl groups, or C3-bithiophenyl with C12-dithiocarbamoyl groups on a 7-deoxycholic amide or cholane derivatives were designed and synthesized. Potentiometric evaluation of the PVC membranes containing those deoxycholic amides/cholanes linked with unsymmetrically substituted tweezer-type bipyridyl or bithiophenyl with dithiocarbamoyl

  设计并合成了含有C3-联吡啶基和C12-二硫代氨基甲酰基或在7-脱氧胆酰胺或胆烷衍生物上具有C12-二硫代氨基甲酰基的C3-联硫苯基的镊子型离子载体。含有与二硫代氨基甲酰基部分不对称取代的镊子型联吡啶或联硫苯基连接的那些脱氧胆酸酰胺/胆烷的PVC膜的电位测量评估证明了它们对银（I）离子的良好亲和性和选择性。尤其是，在cholan-24-amide或胆烷的3α-位具有联硫基苯基部分且在12α-位具有二苯基氨基硫代甲基甲硫基乙酰氧基的离子载体显示出最优异的结果，其理论斜率值为59 mV /十倍。
• Krishnaswamy, N. R.; Kumar, Ch. Siva Sai Kamana; Prasanna, S., Journal of Chemical Research, Miniprint, 1991, # 7, p. 1801 - 1830
  作者：Krishnaswamy, N. R.、Kumar, Ch. Siva Sai Kamana、Prasanna, S.

  DOI：——

  日期：——
• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20090054410A1

  公开（公告）日：2009-02-26

  This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.
• US6312811B1
  申请人：——

  公开号：US6312811B1

  公开（公告）日：2001-11-06