2,3,4-三氟苯乙酰胺 | 149488-98-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,4-三氟苯乙酰胺
• 中文别名: ALPHA-溴-2,3,4,5,6-五氟甲苯
• 英文名称: 2-(2,3,4-Trifluorophenyl)acetamide
• CAS: 149488-98-2
• 化学式: C₈H₆F₃NO
• mdl: MFCD04972480
• 分子量: 189.13
• InChiKey: IHCFTPQWVRBLGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] HETEROARYL COMPOUNDS AS PDE10A INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROARYLE EN TANT QU'INHIBITEURS DE LA PDE 10A
  申请人：GLENMARK PHARMACEUTICAL S A

  公开号：WO2011132048A1

  公开（公告）日：2011-10-27

  The present invention provides heteroaryl compounds as Phosphodiesterase 10A (PDE I OA) inhibitors. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders by inhibiting Phosphodiesterase 10A enzyme. Also provided herein are processes for preparing compounds described herein, Formula (I), intermediates used in their synthesis, pharmaceutical compositions thereof.

  本发明提供了杂环芳基化合物作为磷酸二酯酶10A（PDE10A）抑制剂。具体来说，本文描述的化合物可用于通过抑制磷酸二酯酶10A酶来治疗或预防疾病、症状和/或疾病。本文还提供了制备本文描述的化合物、式（I）、用于它们合成的中间体以及其制药组合物的方法。
• [EN] BIDESMOSIDIC BETULIN AND BETULINIC ACID DERIVATIVES AND USES THEREOF AS ANTITUMOR AGENTS<br/>[FR] DÉRIVÉS DE BÉTULINE BIDESMOSIDIQUE ET D'ACIDE BÉTULINIQUE, ET LEURS UTILISATIONS EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：UNIV QUEBEC A CHICOUTIMI

  公开号：WO2010028487A1

  公开（公告）日：2010-03-18

  The instant application is directed to bidesmosidic betulin and betulinic acid saponin derivatives of formula (I), and use thereof as antitumor agents. In particular, said compounds are effective in treating lung carcinomas, colorectal adenocarcinomas, breast adenocarcinomas, and prostate adenocarcinomas. Methods of synthesizing said compounds through selective glycosylation of the C-28 and C-3 position, and diagnostic methods for identifying tumours suitable for treatment by said compounds are also disclosed.

  该即时申请涉及到公式(I)的双萜基萜苷类的白桦酸和白桦酸皂苷衍生物，以及其作为抗肿瘤剂的用途。具体来说，所述化合物在治疗肺癌、结肠腺癌、乳腺腺癌和前列腺腺癌方面具有有效性。还公开了通过选择性糖基化C-28和C-3位置合成所述化合物的方法，以及用于识别适合通过所述化合物治疗的肿瘤的诊断方法。
• Triazole antifungal agents
  申请人：Pfizer Limited

  公开号：EP0117100A1

  公开（公告）日：1984-08-29

  Compounds of the formula: where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, trifluoromethyl, C1-C4 alkyl and C1-C4 alkoxy, or R is a 5-chloropyrid-2-yl group; and R1 is H, Cl, phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I and trifluoromethyl or a heterocyclic group linked by a carbon atom, and their 0-esters, O-ethers and salts are useful in the treatment of fungal infections in humans and animals and as agricultural fungicides.

  式中 R 是任选被 1 至 3 个各自独立选自 F、Cl、Br、I、三氟甲基、C1-C4 烷基和 C1-C4 烷氧基的取代基取代的苯基，或 R 是 5-氯吡啶-2-基团；R1 是 H、Cl、任选被 1 至 3 个各自独立选自 F、Cl、Br、I 和三氟甲基的取代基取代的苯基或由碳原子连接的杂环基团，它们的 0-酯、O-醚和盐可用于治疗人类和动物的真菌感染，也可用作农用杀真菌剂。
• BIDESMOSIDIC BETULIN AND BETULINIC ACID DERIVATIVES AND USES THEREOF AS ANTITUMOR AGENTS
  申请人：Université du Québec à Chicoutimi

  公开号：EP2340257A1

  公开（公告）日：2011-07-06