2,3-二氟-4-三氟甲基苯甲酸 | 237424-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3-二氟-4-三氟甲基苯甲酸
• 英文名称: 2,3-difluoro-4-(trifluoromethyl)benzoic Acid
• CAS: 237424-17-8
• 化学式: C₈H₃F₅O₂
• mdl: MFCD00236256
• 分子量: 226.1
• InChiKey: URRNELYPUJPPFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi

文献信息

• [EN] EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE INHIBANT EIF4E
  申请人：EFFECTOR THERAPEUTICS INC

  公开号：WO2021003157A1

  公开（公告）日：2021-01-07

  The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

  本发明提供了根据式I合成的化合物、药用可接受的配方和用途，或其立体异构体、互变异构体或药用可接受的盐。对于式I化合物，X1、X2、X3、X4、X5、X6、Q、L1、L2、Y、R1、R2、R3、R4、R5、R6、R7、R8和环A、B和C的定义如规范中所述。创新的式I化合物是eIF4e的抑制剂，并在许多治疗应用中发挥作用，包括但不限于治疗炎症和各种癌症。
• [EN] AMINOQUINAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS<br/>[FR] COMPOSÉS D'AMINOQUINAZOLINE DESTINÉS À LUTTER CONTRE DES INVERTÉBRÉS NUISIBLES
  申请人：BASF SE

  公开号：WO2011036074A1

  公开（公告）日：2011-03-31

  The invention relates to aminoquinazoline compounds or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. Formula (I) wherein A1, A2, A3, A4, R1, R2, R3, R4, R5a, R5b, R5c, R5d and p are defined as in the description.

  该发明涉及氨基喹唑啉化合物或其对映体或兽医学上可接受的盐，用于对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫。该发明还涉及通过使用这些化合物来控制无脊椎动物害虫的方法，以及包含这些化合物的植物繁殖材料和农业和兽医组合物。公式（I）中的A1、A2、A3、A4、R1、R2、R3、R4、R5a、R5b、R5c、R5d和p的定义如描述中所述。
• BICYCLIC ARYL-SULFONIC ACID [1,3,4]-THIADIAZOL-2-YL-AMIDES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE
  申请人：SCHOENAFINGER Karl

  公开号：US20100022603A1

  公开（公告）日：2010-01-28

  The present invention comprises bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, their functional derivatives thereof as well as their physiologically acceptable salts and pharmaceutical compositions thereof that exhibit peroxisome proliferator activated receptor (PPAR) PPARdelta and PPARgamma agonist activity. The structure of the compounds of the invention are defined by Formula I below, wherein the various substituents are defined herein, including their physiologically acceptable salts. Processes for the preparation of compounds are also disclosed. The compounds are suitable for the treatment of fatty acid metabolism and glucose utilization disorders, disorders relating to insulin resistance are involved as well as demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

  本发明涉及双环芳基磺酸[1,3,4]-噻二唑-2-基酰胺及其功能衍生物，以及其生理上可接受的盐和药物组合物，具有过氧化物酶体增殖激活受体（PPAR）PPARδ和PPARγ激动剂活性。本发明化合物的结构由以下式I定义，其中各种取代基在此定义，包括其生理上可接受的盐。本发明还公开了制备该化合物的方法。该化合物适用于治疗与脂肪酸代谢和葡萄糖利用障碍有关的疾病，涉及胰岛素抵抗以及中枢和外周神经系统的脱髓鞘和其他神经退行性疾病。
• Aminoquinazoline Compounds for Combating Invertebrate Pests
  申请人：Gross Steffen

  公开号：US20120178622A1

  公开（公告）日：2012-07-12

  The invention relates to aminoquinazoline compounds or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c , R 5d and p are defined as in the description.

  本发明涉及氨基喹唑啉化合物或其对昆虫害虫，特别是节肢动物害虫和线虫有用的对映体或兽医可接受的盐。本发明还涉及使用这些化合物控制无脊椎动物害虫的方法以及包含该化合物的植物繁殖材料和农业和兽医组合物。其中A1，A2，A3，A4，R1，R2，R3，R4，R5a，R5b，R5c，R5d和p的定义如说明书中所述。
• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS
  申请人：DENALI THERAPEUTICS INC

  公开号：WO2022109268A1

  公开（公告）日：2022-05-27

  The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

  本公开涉及一般与NLR家族Pyrin域含有3（NLRP3）的小分子调节剂有关，或其药学上可接受的盐，同位素富集的类似物，立体异构体，立体异构体混合物或前药，以及其制备方法和中间体，以及使用方法。