2,3-二甲基-1,4-丁二胺 | 127292-54-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2,3-二甲基-1,4-丁二胺
• 英文名称: 2,3-dimethyl-butane-1,4-diamine
• 英文别名: 2,3-dimethyl-1,4-butanediamine；2,3-dimethyl-butanediyldiamine；2,3-Dimethyl-butandiyldiamin；2,3-dimethylbutane-1,4-diamine
• CAS: 127292-54-0
• 化学式: C₆H₁₆N₂
• mdl: MFCD19203813
• 分子量: 116.206
• InChiKey: RMIUJCRSUIITNG-UHFFFAOYSA-N

物化性质

• 沸点：
  167.5±8.0 °C(Predicted)
• 密度：
  0.856±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-二甲基-1,4-丁二胺 生成 diiodoplatinum;2,3-dimethylbutane-1,4-diamine
  参考文献：
  名称：

  NOWATARI, HIROYOSHI;KURODA, YASUO;HAYAMI, HIROSHI;OKAMOTO, KAZUYA;EKIMOTO+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 2406-2409

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二甲基丁二腈 在 diborane(6) 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 2,3-二甲基-1,4-丁二胺
  参考文献：
  名称：

  异鸟氨酸和甲基腐胺的合成。评估它们对鸟氨酸脱羧酶的抑制作用。

  摘要：

  2-（氨基甲基）-4-氨基丁酸（异鸟氨酸），3-甲基异鸟氨酸和2,3-二甲基异鸟氨酸不会被硫代乙酰胺治疗的大鼠的肝脏鸟氨酸脱羧酶（ODC，EC 4.1.1.17）脱羧，但它们是该药的良好竞争抑制剂酶（Ki介于0.72至1.79 mM之间）。当在治疗的大鼠体内进行测定时，还发现上述异鸟氨酸在处死前1小时给药时能抑制肝脏ODC。当在大鼠肝脏ODC上测定从几种异鸟氨酸的脱羧形式正式衍生而来的甲基氨基乙酸时，发现只有2,3-二甲基氨基氨基乙酸降低了酶活性。当在体内测定时，发现在给药后1小时测量ODC活性，ODC活性降低60％。给药4小时后恢复作用。H-35肝癌细胞不吸收异鸟氨酸。因此，它们不会影响其ODC活动。然而，2,3-二甲基腐胺被转运到细胞中并显着降低其ODC活性。

  DOI：

  10.1021/jm00021a024

文献信息

• Homogeneous asymmetric hydrogenation catalyst
  申请人：Shimizu Hideo

  公开号：US20090203927A1

  公开（公告）日：2009-08-13

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种用于均相氢化的有用催化剂，特别是用于均相不对称氢化的催化剂，特别是不对称氢化的催化剂，该催化剂易于获得，在经济性和可操作性方面表现出色，以及一种使用该催化剂产生不饱和化合物的氢化物的方法，特别是使用高产率和光学纯度的该催化剂产生手性活性化合物。
• Chiral porous metal phosphonates for heterogeneous asymmetric catalysis
  申请人：——

  公开号：US20040192543A1

  公开（公告）日：2004-09-30

  Chiral porous zirconium phosphonates containing metal complex moieties are provided, synthesized via a molecular building block approach, and characterized by a variety of techniques including TGA, adsorption isotherms, XRD, SEM, IR, and microanalysis. These hybrid solids may be used for enantioselective heterogeneous asymmetric hydrogenation of aromatic ketones with remarkably high e.e. values of up to 99.2%. Similarly prepared chiral porous solids may be used for asymmetric hydrogenation of &bgr;-keto esters with e.e.'s of up to 95%. The solid catalysts can also be easily recycled and reused multiple times without the loss of activity and enantioselectivity. Ready tunability of such a molecular building block approach allows the optimization of these hybrid materials to provide practically useful heterogeneous asymmetric catalysts.

  提供含有金属配合物基团的手性多孔氧化锆膦酸盐，通过分子建筑模块方法合成，并通过多种技术进行表征，包括TGA、吸附等温线、XRD、SEM、IR和微量分析。这些混合固体可用于对芳香酮进行手性选择性的非均相不对称加氢，其对映体过量值高达99.2%。类似地制备的手性多孔固体可用于对β-酮酯进行不对称加氢，其对映体过量值可高达95%。这种固体催化剂还可以轻松回收和多次重复使用，而不会丧失活性和手性选择性。这种分子建筑模块方法的便捷可调性允许优化这些混合材料，提供实用的非均相手性催化剂。
• METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
  申请人：DOT Therapeutics-1, Inc.

  公开号：US20200317659A1

  公开（公告）日：2020-10-08

  The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale. Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof. wherein each symbol is as defined in the specification.

  本发明的目的是提供一种能够在工业规模上生产光学活性嘧啶酰胺衍生物的方法。化合物（I）或其盐经过不对称还原反应，得到的化合物（II）或其盐经过去保护反应，得到的化合物（III）或其盐与化合物（VI）或其盐反应，得到化合物（V）或其盐，其中每个符号如规范中定义的那样。
• RHODIUM CATALYST AND METHOD FOR PRODUCING AMINE COMPOUND
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20150051416A1

  公开（公告）日：2015-02-19

  [Problem] Provision of a superior rhodium catalyst and a production method of amine compound. [Solving Means] A rhodium complex coordinated with a compound represented by the formula

  提供一种优质的铑催化剂和胺化合物的生产方法。采用与公式表示的化合物配位的铑络合物。
• Novel ruthenium complexes and process for preparing alcoholic compounds using these
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：US20030166978A1

  公开（公告）日：2003-09-04

  The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand. In a preferred embodiment, the invention provides an optically active ruthenium complex represented by the general formula (1) 1 wherein X and Y, which can be identical to or different from each other, represent a hydrogen atom or an anion group, R 1 and R 2 , which can be identical to or different from each other, represent a chain or cyclic hydrocarbon group of carbon number 1 to 20, which can be substituted, R 3 and R 4 , which can be identical to or different from each other, represent a hydrogen atom or a hydrocarbon group of carbon number 1 to 3, and R 5 , R 6 , R 7 and R 8 , which can be identical to or different from one another, represent a hydrocarbon group of carbon number 1 to 30, which can be substituted, with the proviso that when X and Y are bromine, R 1 and R 2 are a methyl group, and when R 3 and R 4 are a hydrogen atom, at least one of R 5 , R 6 , R 7 and R 8 is not a phenyl group.

  这项发明提供了具有光学活性二膦化合物的新型钌配合物，该二膦化合物在碳上具有不对称性且易于合成，作为配体，并提供了一种利用该配合物作为催化剂制备光学活性醇化合物的方法，其中所述方法是制备光学活性醇化合物的方法，与具有轴向手性或在碳上具有不对称性的光学活性二膦化合物作为配体的传统钌配合物催化剂相比，在羰基化合物的不对称氢化中具有较高的反应活性、对映选择性等方面表现出色。在优选实施方式中，该发明提供了一种由通式（1）1表示的光学活性钌配合物，其中X和Y可以相同或不同，表示氢原子或阴离子基团，R1和R2可以相同或不同，表示碳数为1至20的链状或环烃基团，可以被取代，R3和R4可以相同或不同，表示碳数为1至3的氢原子或烃基团，R5、R6、R7和R8可以相同或不同，表示碳数为1至30的烃基团，可以被取代，但当X和Y为溴时，R1和R2为甲基基团，且当R3和R4为氢原子时，R5、R6、R7和R8中至少有一个不是苯基团。