2,3-二甲基-[1,1'-联苯]-4-胺 | 22750-87-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3-二甲基-[1,1'-联苯]-4-胺
• 英文名称: 2,3-Dimethyl-4-biphenylamine
• 英文别名: 2,3-dimethyl-4-phenylaniline
• CAS: 22750-87-4
• 化学式: C₁₄H₁₅N
• 分子量: 197.27
• InChiKey: LDPZCROLNGKTOX-UHFFFAOYSA-N

物化性质

• 沸点：
  312.6±11.0 °C(Predicted)
• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
  申请人：MUSC Foundation For Research Development

  公开号：EP2189522A1

  公开（公告）日：2010-05-26

  Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX 2 can be by administration of a nucleic acid encoding an siRNA for PAX 2. Dharmachon is a commercial source for such siRNAs. A method of treating cancer in a subject by administering DEFBI is also provided. An example of a cancer treated by the present method is prostate cancer. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFBI in the subject. In the method wherein the expression of DEFB1 is increased, it can be increased by blocking the binding of PAX2 to the DEFBI promoter.; The blocking of binding of PAX2 to the DEFBI promoter can be by administration of an oligonucleotide containing the PAX2 DNA binding site of DEFBI. This oligonucleotide can be complementary to the sequence of PAX2 that binds to the DEFBI promoter. Alternatively, the oligonucleotide can interact with the PAX2 in a way that inhibits binding to DEFBI. This interaction can be based on three-dimensional structure rather than primary nucleotide sequence.

  本发明提供了一种通过抑制 PAX2 的表达来治疗受试者癌症的方法。本方法治疗癌症的一个例子是前列腺癌。在所公开的癌症治疗方法中，抑制 PAX 2 表达的方法可以是施用编码 PAX 2 siRNA 的核酸。Dharmachon 公司是此类 siRNA 的商业来源。还提供了一种通过施用 DEFBI 治疗受试者癌症的方法。本方法治疗癌症的一个例子是前列腺癌。同样，还提供了一种通过增加受试者体内 DEFBI 的表达来治疗癌症的方法。在增加 DEFB1 表达的方法中，可以通过阻断 PAX2 与 DEFBI 启动子的结合来增加 DEFB1 的表达。这种寡核苷酸可以与与 DEFBI 启动子结合的 PAX2 序列互补。或者，该寡核苷酸可以抑制与 DEFBI 结合的方式与 PAX2 相互作用。这种相互作用可以基于三维结构而不是主核苷酸序列。
• Targeting PAX2 for the treatment of breast cancer
  申请人：Donald Carlton D.

  公开号：US11033628B1

  公开（公告）日：2021-06-15

  The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.

  本申请提供了通过抑制 PAX2 的表达来预防和/或治疗受试者乳腺癌的方法。在所公开的癌症治疗方法中，抑制 PAX2 表达的方法可以是施用编码 PAX2 siRNA 的核酸。还提供了一种通过施用 DEFB1 治疗受试者癌症的方法。同样，还提供了一种通过增加受试者体内 DEFB1 的表达来治疗癌症的方法。
• EP0730447A4
  申请人：——

  公开号：EP0730447A4

  公开（公告）日：1999-01-27
• FATTY ACID DELIVERY SYSTEM
  申请人：COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

  公开号：EP0730447B1

  公开（公告）日：2002-02-20
• METHOD AND MEANS FOR IMPROVING BOWEL HEALTH
  申请人：Commonwealth Scientific and Industrial Research Organisation

  公开号：EP1833291A1

  公开（公告）日：2007-09-19