2,4,6-三异丙基苯磺酰基四唑 | 59128-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4,6-三异丙基苯磺酰基四唑
• 英文名称: 2,4,6-Triisopropylbenzenesulfonyltetrazole
• 英文别名: 1-[2,4,6-tri(propan-2-yl)phenyl]sulfonyltetrazole
• CAS: 59128-88-0
• 化学式: C₁₆H₂₄N₄O₂S
• 分子量: 336.5
• InChiKey: PWLNMVIUTUFFSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 4'-O-METHYLENE PHOSPHONATE NUCLEIC ACIDS AND ANALOGUES THEREOF<br/>[FR] ACIDES NUCLÉIQUES PHOSPHONATE DE 4'-O-MÉTHYLÈNE ET ANALOGUES DE CEUX-CI
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2021146488A1

  公开（公告）日：2021-07-22

  The present invention relates to nucleic acids and analogues thereof useful as potent and stable RNA interference agents.

  本发明涉及用作有效和稳定的RNA干扰剂的核酸及其类似物。
• Method for synthesizing cyclic bisdinucleoside
  申请人：Hayakawa Yoshihiro

  公开号：US20060167241A1

  公开（公告）日：2006-07-27

  A compound represented by Formula [2]: wherein R 2 and R 3 each independently represent a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group or a hydroxyl group; and B 2 and B 3 each independently represent a nucleic acid base, or a salt thereof can be synthesized from a compound represented by Formula [1]: wherein R 1 represents a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group, or a hydroxyl group substituted with a hydroxyl protecting group; and B 1 represents a nucleic acid base which may be protected.

  化合物的化学式为[2]，其中R2和R3各自独立地表示氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基；B2和B3各自独立地表示核酸碱基或其盐。该化合物可以从化学式[1]表示的化合物合成，其中R1表示氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基，且带有羟基保护基；B1表示可能被保护的核酸碱基。
• Plasmid for transforming bacterial host to render it capable of polypeptide expression
  申请人：GENENTECH, INC.

  公开号：EP0001929A2

  公开（公告）日：1979-05-16

  Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormones (e.g., somatostatin) and other polypeptides, in- duding plasmids suited for the transformation of bacterial hosts are prepared. The latter incorporate a regulon homologous to the host in its untransformed state, in reading phase with the structural gene for the heterologous DNA.

  重组微生物克隆载体包括用于表达哺乳动物激素（如体生长抑素）和其他多肽的异源 DNA 编码，以及适合转化细菌宿主的质粒。 后者含有与宿主未转化状态下同源的调节子，与异源 DNA 的结构基因处于阅读相位。
• Synthetic DNA, process for preparing it and recombinant microbial cloning vehicle containing such DNA
  申请人：GENENTECH, INC.

  公开号：EP0001931A2

  公开（公告）日：1979-05-16

  Synthetic DNA coding for a mammalian polypeptide, e.g. somatostatin, is prepared in which at least a majority of the codons are those preferred for the expression of microbial genomes. The DNA is prepared by joining together two appropriately coded series of fragments by hydrogen bonding and then completing the two strands by ligation, the fragments lacking complementarity other than in the correct sequence. Such synthetic DNA having a restriction endonuclease site at each end of the gene can be introduced into a microbial cloning vehicle which can then be used for transformation of bacterial hosts.

  制备哺乳动物多肽（如体生长抑素）编码的合成 DNA，其中至少大部分密码子是微生物基因组优选表达的密码子。DNA 的制备方法是通过氢键将两个适当编码的系列片段连接在一起，然后通过连接完成两条链，除正确的序列外，这些片段缺乏互补性。 这种合成 DNA 的基因两端各有一个限制性内切酶位点，可将其引入微生物克隆载体，然后用于转化细菌宿主。
• Method for polypeptide production involving expression of a heterologous gene, recombinant microbial cloning vehicle containing said gene and bacterial culture transformed by said cloning vehicle
  申请人：GENENTECH, INC.

  公开号：EP0001930A2

  公开（公告）日：1979-05-16

  Specific polypeptides are prepared by expression of a heterologous gene coding for them in a recombinant microbial cloning vehicle. The gene is arranged to be in reading phase with a DNA sequence coding for another polypeptide so that when the DNA is expressed a precursor protein is produced comprising both the desired polypeptide and the additional polypeptide, there being a cleavage site between them where the precursor protein may subsequently be cleaved. Plasmids or cloning vehicles containing this type of DNA sequence may be used to transform bacterial cultures in particular to enable the bacteria to produce an immunogenic substance comprising a polyeptide hapten, the DNA sequence coding for the hapten and an additional protein sufficient in size to confer immunogenicity on the product of expression and enable antibodies to be raised to it. Alternatively, the bacteria may be enabled to produce a desired polypeptide product e.g. somatostatin linked to additional protein from which the desired product may be cleaved.

  通过在重组微生物克隆载体中表达编码特定多肽的异源基因来制备特定多肽。该基因与编码另一种多肽的 DNA 序列处于阅读相位，这样，当 DNA 表达时，就会产生一种前体蛋白，其中包括所需的多肽和另一种多肽，它们之间有一个裂解位点，随后前体蛋白可在该位点被裂解。 含有这种 DNA 序列的质粒或克隆载体可用来转化细菌培养物，特别是使细菌产生一种免疫原性物质，这种物质包括多肽合蛋白、编码合蛋白的 DNA 序列和一种额外的蛋白质，其大小足以使表达产物具有免疫原性，并能产生抗体。或者，也可使细菌产生所需的多肽产物，如与附加蛋白质相连的体生长抑素，所需的产物可从附加蛋白质中裂解出来。