2,4-二甲基苯乙胺 | 76935-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二甲基苯乙胺
• 英文名称: 2-(2,4-dimethylphenyl)ethanamine
• 英文别名: 2,4-Dimethylphenethylamine
• CAS: 76935-60-9
• 化学式: C₁₀H₁₅N
• mdl: MFCD01310816
• 分子量: 149.236
• InChiKey: VQGZTRKXOUWMAC-UHFFFAOYSA-N

物化性质

• 沸点：
  95°C 10mm
• 密度：
  0,95 g/cm3
• 闪点：
  101℃

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT-HARMFUL, CORROSIVE
• 危险品标志：
  Xi,C
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R34
• 海关编码：
  2921499090
• 危险品运输编号：
  UN 2735

反应信息

• 作为反应物：
  描述：

  2,4-二甲基苯乙胺 生成 N-[2-(2,4-dimethylphenyl)ethyl]-N'-1H-indazol-4-ylurea
  参考文献：
  名称：

  Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

  摘要：

  式（I）的化合物是新颖的VR1拮抗剂，可用于治疗疼痛、炎症性热性过敏、尿失禁和膀胱过度活动。

  公开号：

  US20040157849A1
• 作为产物：
  描述：

  2,4-二甲基苄腈 在 氨 、 镍 作用下， 100.0 ℃ 、7.84 MPa 条件下， 生成 2,4-二甲基苯乙胺
  参考文献：
  名称：

  Hormonal control of a gene encoding a putative PDR5-like ABC transporter in periwinkle

  摘要：

  ATP binding cassette (ABC) transporters retain increasing attention since their implication in multidrug resistance has been demonstrated in several prokaryotic and eukaryotic cells. Many ARC proteins are known in various organisms but only few in higher plants. We report here on the characterization of a partial 955 bp clone (Cr-ABC1) isolated from a Catharanthus roseus cDNA library, which shows high homology (65% identity) with the TUR2 cDNA previously isolated from the water lens Spirodela polyrrhiza. Accumulation of Cr-ABC1 transcripts in cultured C. roseus cells was enhanced by cytokinin or methyl jasmonate addition to, or auxin suppression from the culture medium. In whole plants, the gene was mainly expressed in flowers.

  DOI：

  10.1080/12538078.2000.10515842

文献信息

• [EN] AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS<br/>[FR] (THIO)AMIDES AZABICYCLIQUES EN TANT QUE COMPOSÉS FONGICIDES
  申请人：BAYER AG

  公开号：WO2021233861A1

  公开（公告）日：2021-11-25

  The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds

  本发明涉及吡啶环(硫)酰胺化合物及其用途，用于控制植物病原微生物，如植物病原真菌。它还涉及制备这些化合物的过程和中间体。
• [EN] GUANIDINE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE GUANIDINE ET LEUR UTILISATION
  申请人：HANALL BIOPHARMA CO LTD

  公开号：WO2015160220A1

  公开（公告）日：2015-10-22

  The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

  本发明涉及用于抑制线粒体氧化磷酸化（OXPHOS）的胍啉化合物及其使用。更具体地，本发明涉及一种用于预防或治疗与OXPHOS相关的疾病，特别是通过抑制线粒体氧化磷酸化和重编程细胞代谢的药物组合物。
• [EN] PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES<br/>[FR] DÉRIVÉS DE PHÉNÉTHYLAMIDE ET LEURS ANALOGUES HÉTÉROCYCLIQUES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010044054A1

  公开（公告）日：2010-04-22

  The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

  这项发明涉及新型苯乙酰胺衍生物及其异环类似物，其化学式为(I)，其中A、B、R1、R2和R3如申请中所述，并且涉及将这种化合物或这种化合物的药用可接受盐用作药物，特别是促进睡眠的药物受体拮抗剂。
• INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
  申请人：Gandhi Virajkumar B.

  公开号：US20080161280A1

  公开（公告）日：2008-07-03

  Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

  聚(ADP核糖)聚合酶抑制剂、制备方法以及利用它们治疗患者的方法被披露。
• [EN] 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES<br/>[FR] DÉRIVÉS DE L'ACIDE CARBOXYLIQUE PHÉNOXYCHROMANE SUBSTITUÉS EN 6
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2009158426A1

  公开（公告）日：2009-12-30

  Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

  式（I）的化合物：其中A1、A2、W、L、G、R7a、R7b、R8、R9和R10具有规范中给定的含义，是DP2受体调节剂，可用于治疗免疫性疾病。