2,5-呋喃二酮,3-甲基-4-(1-甲基乙基)- | 111829-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 中文名称: 2,5-呋喃二酮,3-甲基-4-(1-甲基乙基)-
• 英文名称: 3-methyl-4-isopropylfuran-2,5-dione
• 英文别名: isopropyl-methyl-maleic acid-anhydride；Isopropyl-methyl-maleinsaeure-anhydrid；2-isopropyl-3-methylmaleic anhydride；3-methyl-4-propan-2-ylfuran-2,5-dione
• CAS: 111829-44-8
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: DXJIVVBEZVYYBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-dichloro-3-methylbutanoyl chloride 在 吡啶 、 四甲基乙二胺 、 sodium carbonate 、 copper(l) chloride 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 40.5h， 生成 2,5-呋喃二酮,3-甲基-4-(1-甲基乙基)-
  参考文献：
  名称：

  CuCl催化N -α-全氯酰基-烯酮-N，S-缩醛的自由基环化：制备双取代马来酸酐的新方法

  摘要：

  研究了N -α-全氯酰基环状烯酮-N，X（X = O，N R，S）-乙缩醛的铜催化自由基环化（RC）。同时的RC Ñ酰基二硫缩烯酮Ñ，ö -acetals不成功，5-内提供更好的结果的其它烯酮缩醛的环化，以环化效率顺序如下：六原子环二硫缩烯酮Ñ，Ñ ř -乙缩醛<五原子环烯酮-N，S-乙缩醛<六原子环烯酮-N，S-缩醛。催化循环总是从氨基甲酰基甲基自由基的形成开始。这导致反应级联，包括自由基极性交叉步骤，该步骤以马来酰亚胺核或其前体的形成结束。来自六原子环状烯酮-N，S-乙缩醛的RC的产物被有效地转化为二取代的马来酸酐。

  DOI：

  10.1016/j.tet.2012.04.117

文献信息

• Metallo-beta-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US20080090825A1

  公开（公告）日：2008-04-17

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  一种新的金属β-内酰胺酶抑制剂，作为一种药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-BETA-LACTAMASE INHIBITORS
  申请人：Chikauchi Ken

  公开号：US20120071457A1

  公开（公告）日：2012-03-22

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明揭示了一种新型金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。将通式（I）化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• Metallo-β-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US09260375B2

  公开（公告）日：2016-02-16

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-B-LACTAMASE INHIBITORS
  申请人：MEIJI SEIKA KAISHA, LTD.

  公开号：US20160151322A1

  公开（公告）日：2016-06-02

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式(I)的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式(I)的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• Imidazoline derivatives, process for preparing same, herbicide containing same, and plant growth regulator containing same
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0227967A2

  公开（公告）日：1987-07-08

  Imidazoline derivatives represented by the general for- muia: or (wherein all the symbols are as defined in appended claims), a process for preparation of said derivatives, and a herbicide or a plant growth regulator containing said derivative as an active component are described. These derivatives are novel compounds, and the herbicide containing said derivative as an active component exhibits excellent herbicidal activity against various weeds without phytotoxicity on useful agricultural products. The plant growth regulator containing said derivatives as an active component exhibits excellent growth regulating activity against turf etc. without phytotoxicity thereon.

  咪唑啉衍生物，由一般芴甲氧羰基化合物或芴甲氧羰基化合物代表： 或 (其中所有符号如所附权利要求中所定义）、制备上述衍生物的工艺以及含有上述衍生物作为活性成分的除草剂或植物生长调节剂。这些衍生物是新型化合物，含有上述衍生物作为活性成分的除草剂对各种杂草具有优异的除草活性，且对有用的农产品无植物毒性。含有上述衍生物作为活性成分的植物生长调节剂对草皮等具有优异的生长调节活性，而不会对其产生植物毒性。