2,7-二氮杂螺[4.4]-3,8-壬二酮 | 947239-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂螺环衍生物
• 中文名称: 2,7-二氮杂螺[4.4]-3,8-壬二酮
• 英文名称: 2,7-diazaspiro<4.4>nonane-3,8-dione
• 英文别名: 2,7-diazaspiro[4.4]nonane-3,8-dione
• CAS: 947239-51-2
• 化学式: C₇H₁₀N₂O₂
• mdl: MFCD11226906
• 分子量: 154.169
• InChiKey: GLUGRUJRPBFVMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,7-二氮杂螺[4.4]-3,8-壬二酮 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 2,7-二苄基-2,7-二氮杂-螺[4.4]壬烷
  参考文献：
  名称：

  Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

  摘要：

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.

  DOI：

  10.1021/jm00170a035
• 作为产物：
  描述：

  3,3-二氰基戊二酸二乙酯 在 钴 氢气 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 23.0h， 以32%的产率得到2,7-二氮杂螺[4.4]-3,8-壬二酮
  参考文献：
  名称：

  Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

  摘要：

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.

  DOI：

  10.1021/jm00170a035

文献信息

• NOVEL AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090264403A1

  公开（公告）日：2009-10-22

  The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryidihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

  本发明涉及含氮杂环取代的芳基二氢异喹啉酮及其衍生物、其生理上可耐受的盐和生理功能衍生物、其制备方法、包含本发明中至少一种含氮杂环取代的芳基二氢异喹啉酮或其衍生物的药物以及将本发明中的含氮杂环取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂。
• Kajtar, Marton; Hollosi, Miklos; Kinsky, Klaus, Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 3, p. 936 - 949
  作者：Kajtar, Marton、Hollosi, Miklos、Kinsky, Klaus、Majer, Zsuzsanna

  DOI：——

  日期：——
• CULBERTSON, TOWNLEY P.;SANCHEZ, JOSEPH P.;GAMBINO, LAURA;SESNIE, JOSEPHIN+, J. MED. CHEM., 33,(1990) N, C. 2270-2275
  作者：CULBERTSON, TOWNLEY P.、SANCHEZ, JOSEPH P.、GAMBINO, LAURA、SESNIE, JOSEPHIN+

  DOI：——

  日期：——
• KAJTAR, M.;HOLLOSI, M.;KINSKY, K.;MAJER, Z., COLLECT. CZECH. CHEM. COMMUN., 1982, 47, N 3, 936-949
  作者：KAJTAR, M.、HOLLOSI, M.、KINSKY, K.、MAJER, Z.

  DOI：——

  日期：——
• AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SANOFI

  公开号：EP1987020B1

  公开（公告）日：2012-10-03