2,7-二氮杂螺[4.4]-3-壬酮 | 1226550-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂螺环衍生物
• 中文名称: 2,7-二氮杂螺[4.4]-3-壬酮
• 中文别名: 2,7-二氮杂螺[4,4]壬烷-3-酮
• 英文名称: 2,7-Diazaspiro[4.4]nonan-3-one
• CAS: 1226550-00-0
• 化学式: C₇H₁₂N₂O
• mdl: MFCD19226811
• 分子量: 140.18
• InChiKey: WIGUNJUDINBXPD-UHFFFAOYSA-N

物化性质

• 沸点：
  352.9±35.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

文献信息

• [EN] INHIBITORS OF THE MENIN-MLL INTERACTION<br/>[FR] INHIBITEURS DE L'INTERACTION MÉNINE-MLL
  申请人：VITAE PHARMACEUTICALS INC

  公开号：WO2017214367A1

  公开（公告）日：2017-12-14

  The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

  本发明涉及抑制menin与MLL及MLL融合蛋白相互作用的抑制剂，包含这些抑制剂的药物组合物，以及它们在治疗由menin-MLL相互作用介导的癌症和其他疾病中的应用。
• [EN] PD-1/PD-L1 INHIBITORS<br/>[FR] INHIBITEURS PD-1/PD-L1
  申请人：GILEAD SCIENCES INC

  公开号：WO2019204609A1

  公开（公告）日：2019-10-24

  Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed Formula (I)

  公开了用于治疗癌症的化合物及使用该化合物单独或与其他药剂组合使用的方法和该化合物的组合物的配方（I）。
• 2-Aminoquinoline derivatives
  申请人：Moriya Minoru

  公开号：US20060287340A1

  公开（公告）日：2006-12-21

  This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R 1 and R 2 either stand for lower alkyl, lower cycloalkyl, etc., or R 1 and R 2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R 3 , R 4 , R 5 , R 6 and R 7 stand for hydrogen, lower alkyl, etc.; R 8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.

  本发明提供了由通式[I]表示的2-氨基喹啉衍生物[其中R1和R2代表低碳基、低环烷基等，或者R1和R2共同形成一个与它们结合的氮杂环的脂肪族氮杂环；R3、R4、R5、R6和R7代表氢、低碳基等；R8代表低碳基、低碳基氧杂基等；n代表0-4的整数]。这些化合物作为黑色素浓集激素受体拮抗剂，并且可用于治疗中枢神经系统疾病、心血管疾病和代谢性疾病。
• COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF
  申请人：Medshine Discovery Inc.

  公开号：EP4043461A1

  公开（公告）日：2022-08-17

  A biaryl compound. Specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

  一种双芳基化合物。具体公开的是由式(I)表示的化合物及其药学上可接受的盐。
• [EN] ANTICANCER COMPOUNDS<br/>[FR] COMPOSÉS ANTICANCÉREUX
  申请人：UNIV CALIFORNIA

  公开号：WO2022261204A1

  公开（公告）日：2022-12-15

  Disclosed are compounds of formula (I): formula (I) and pharmaceutically acceptable salts thereof. The compounds of the invention are BDII- selective inhibitors of BET proteins, and have therapeutic potential for treating cancer, acute kidney disease, and viral infections, among other diseases.

  本发明涉及以下公式（I）的化合物：公式（I）及其药学上可接受的盐。本发明的化合物是BET蛋白的BDII选择性抑制剂，具有治疗癌症、急性肾脏疾病、病毒感染等疾病的治疗潜力。